Abstract: The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for regenerating spinal cord or brain neurons within a subject having a spinal cord injury (SCI), stroke or other neurotraumatic conditions.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: There is described a computer-implemented method for rendering video stream outputs, the method comprising; generating a rendering pipeline comprising a plurality of rendering tasks; determining a first rendering task of the plurality of rendering tasks to be rendered differently dependent on one or more characteristics of a user; and producing a first video stream output to be displayed to a first user having a first characteristic; and amending the first rendering task based on a characteristic of a second user, wherein the characteristic of the second user is different to that of the first user, and producing a second video stream output to be displayed to the second user. There is also described a computer program product and a system.

Abstract: Methods, systems, and apparatus for executing, by a local processing device, a first instance of the application associated with a first user of the local processing device, receiving data output by a second instance executed by the remote processing device, the second instance of the application being associated with a second user of the local processing device, identifying a first synchronization point within the first instance, identifying a second synchronization point associated with the second instance, determining a temporal offset between the first instance and the second instance using the first synchronization point and the second synchronization point, and implementing one or more modifications to one or more of the first instance and the second instance to reduce the temporal offset.

Abstract: Methods, systems, and apparatus for executing the first instance responsive to first input received from a first input device associated with the local processing device, the second instance being responsive to second input received from a second input device associated with the local processing device, determining a first degree of similarity between a first video output of the first instance and a second video output of the second instance, and determining that the first degree of similarity meets or exceeds a threshold degree of similarity and, and at least partially in response, implementing one or more modifications, a first modification including ceasing, by the local processing device, display of one of the first video output and the second video output, and displaying, by the local processing device, another of the first video output and the second video output.

Abstract: A molten salt impurities sensor makes use of absorption spectrometry through a specially constructed and hardened probe inserted in the molten salt. The probe provides an opposed window and mirror, both adapted to resist the influence of molten salt, to allow the passage of light from the absorption spectrometer through the window to reflect off of the mirror and to be returned to the absorption spectrometer after passing through the molten salt.

Abstract: A dual-purpose gift-wrapping material specifically designed for hunters and outdoor enthusiasts comprises a sheet having wildlife-themed decorative artwork on a first surface and functional shooting targets on a second surface. The decorative surface features original wildlife imagery suitable for gift presentation, while the reverse surface incorporates shooting targets with grid patterns for firearm sighting and practice applications. The invention provides extended utility beyond conventional single use wrapping paper by serving both decorative and practical functions relevant to the hunting community.

Abstract: Systems and methods for automated data extraction of unstructured documents can include includes a processor coupled with memory, and configured to receive, from a client device, an electronic document corresponding to a client account and identify, from a plurality of classifications, a classification for at least a portion of the electronic document. Based on the classification, the processor can select a set of prompts for artificial intelligence models according to an extraction plan specifying the prompts and mapping rules to extract data elements from the document. The processor can transform the extracted data elements to map to predefined sets, establish relationships between normalized entities, and compare attributes of the electronic document with attributes of documents corresponding to different client accounts. The system can generate, based on comparisons, a parameter for an extracted data element and provide, for display on the client device, the parameter as a grade, score, or recommendation.

Abstract: Methods, systems, and apparatus for executing a video game can include executing a first instance at a first processing device, receiving data from a second processing device over a network, the data corresponding to a second instance executed concurrently with the first instance, the second instance being instantiated by the second processing device in response to one or more events detected by the first processing device, providing inputs received from the first control device to the first instance of the video game, the first instance being responsive to inputs received from the first control device, transmitting inputs received from the second control device to the second processing device, the second instance being responsive to inputs received from the second control device, generating images for display based on the first instance and the second instance, and displaying the generated images.

Abstract: Systems and methods for automated data extraction of unstructured documents can include includes a processor coupled with memory, and configured to receive, from a client device, an electronic document corresponding to a client account and identify, from a plurality of classifications, a classification for at least a portion of the electronic document. Based on the classification, the processor can select a set of prompts for artificial intelligence models according to an extraction plan specifying the prompts and mapping rules to extract data elements from the document. The processor can transform the extracted data elements to map to predefined sets, establish relationships between normalized entities, and compare attributes of the electronic document with attributes of documents corresponding to different client accounts. The system can generate, based on comparisons, a parameter for an extracted data element and provide, for display on the client device, the parameter as a grade, score, or recommendation.

Abstract: A molten salt impurities sensor makes use of absorption spectrometry through a specially constructed and hardened probe inserted in the molten salt. The probe provides an opposed window and mirror, both adapted to resist the influence of molten salt, to allow the passage of light from the absorption spectrometer through the window to reflect off of the mirror and to be returned to the absorption spectrometer after passing through the molten salt.

Abstract: Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitors and their use in treating or preventing cardiovascular diseases are disclosed.

Abstract: The present disclosure provides c-Met antibody drug conjugates (ADCs), including compositions and methods of using such ADCs.

Abstract: A technique facilitates deployment of open hole gravel packing equipment and sand control equipment downhole in a single trip. According to an embodiment, the technique utilizes a pipe string, e.g. a workstring or a drill string, for use in an open hole gravel packing operation. The pipe string is equipped with a sand control system having at least one filtration medium, Additionally, the pipe string comprises a valve and a valve actuation device. The valve actuation device is capable of being remotely activated in a manner allowing setting of one or more packers downhole without blocking subsequent flow through the pipe string.

Abstract: A bonded seal includes a metal alloy substrate, a bonding agent, and a perfluoroelastomer bonded to at least a portion of the metal alloy substrate via the bonding agent.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed for a stair barrier system configured for positioning on a staircase. An example stair barrier system includes first and second barriers, each barrier having a body portion, a base portion, and an adjustable member, wherein the adjustable member is adapted to exert a force on a side surface perpendicular to the staircase. Each body portion has a body height greater than a body width, wherein each base portion includes a first end and a second end and has a base width greater than the body width. The body portion of the first barrier is above the first end of the base portion, and wherein the body portion of the second barrier is above the second end of the base portion.

Abstract: A sliding sleeve design for downhole components is provided. The sliding sleeve can be used in gas lift systems.

Abstract: Compositions include biosensors and enzyme substrates for use in the biosensors. Methods of identifying modulators of enzymatic activity include the biosensors.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: A technique facilitates deployment of open hole gravel packing equipment and sand control equipment downhole in a single trip. According to an embodiment, the technique utilizes a pipe string, e.g. a workstring or a drill string, for use in an open hole gravel packing operation. The pipe string is equipped with a sand control system having at least one filtration medium, Additionally, the pipe string comprises a valve and a valve actuation device. The valve actuation device is capable of being remotely activated in a manner allowing setting of one or more packers downhole without blocking subsequent flow through the pipe string.