Abstract: Aspects and embodiments disclosed herein include a method for forming a plurality of microfeatures, the method comprising: irradiating a starting multi-layer material with a pulsed laser beam at a plurality of locations of the multi-layer material; wherein: the starting multi-layer material comprises a plurality of starting layers comprising a first starting layer having a first composition and a second starting layer adjacent to the first starting layer and having a second composition different than the first composition; the plurality of microfeatures form in the multi-layer starting material during the step of irradiating; each microfeature comprises a plurality of microfeature layers comprising a first microfeature layer having the first composition and a second microfeature layer having the second composition. Optionally, each of the first and second composition is an inorganic material.

Abstract: A method for laser-processing a metallic surface to produce a functionalized metallic surface comprises: providing a substrate having the metallic surface; applying a pulsed laser beam with a controlled fluence to a region of the metallic surface in an environment containing oxygen, wherein metal material in the region of the metallic surface ablates due to the applied pulsed laser beam and wherein at least a portion of the ablated metal material oxidizes and redeposits on the metallic surface to produce one or more oxidized-metal-coated structures; wherein the metallic surface having the one or more oxidized-metal-coated structures is the functionalized metallic surface. Optionally, the functionalized metallic surface has a higher hemispherical emissivity than the metallic surface free of the oxidized-metal-coated structures and prior to applying the pulsed laser beam under otherwise identical conditions.

Abstract: A system for identifying a user of a controller includes a controller having one or more sensors configured to detect interaction with the controller by the user and a transmitter configured to transmit telemetry data based on outputs of one or more of the sensors, a user profile unit configured to obtain user profile data for one or more user profiles, where each user profile corresponds to a respective user and the user profile data for a user profile comprises data indicative of one or more characteristic interactions by the user with the controller, and a user profile selection unit configured to select a user profile from the one or more user profiles in dependence upon a degree of match between one or more properties of the transmitted telemetry data and the data of each respective user profile, and configured to modify an output of the system responsive to the selection.

Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: A vision-cued random-access LIDAR system and method which determines the location and/or navigation path of a moving platform. A vision system on a moving platform identifies a region of interest. The system classifies objects within the region of interest, and directs random-access LIDAR to ping one or more of the classified objects. The platform is located in three dimensions using data from the vision system and LIDAR. The steps of classifying, directing, and locating are preferably performed continuously while the platform is moving and/or the vision system's field-of-view (FOV) is changing. Objects are preferably classified using at least one smart-vision algorithm, such as a machine-learning algorithm.

Abstract: A method to reduce corrosion rates of materials at high temperatures may include heating a mixture and applying the heated mixture to a material to be rendered thermodynamically noble. The mixture may include carbon monoxide and carbon dioxide and the material rendered thermodynamically noble may include copper or other material having similar physical properties. The copper or other similar material may be applied to a structural material and provide a surface interfacing with the mixture of carbon monoxide and carbon dioxide to prevent corrosion of the structural material. In some cases, the structural material may form a heat exchanger defining passageways for a working fluid of a power system and/or may form other passageways of the power system. The copper may be applied to the passageways as a protective coating and then made thermodynamically noble at high temperatures after interactions with the mixture of carbon monoxide and carbon dioxide.

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: A test and measurement instrument includes a processor configured to execute instructions that cause the processor to: receive a bus auto-detect signal; receive signals from a bus connected to the test and measurement instrument; and apply machine learning to the signals from the bus to output a predicted a bus type; at least one memory to store the instructions and data used in the machine learning, and a display to display information for a user including the predicted bus type. A method of automatically detecting a bus type includes receiving a bus auto-detect signal when a bus is connected to a test and measurement instrument, receiving signals from the bus at a processor, and using the processor to apply machine learning to the signals from the bus to predict a bus identity.

Abstract: A bonded seal includes a metal alloy substrate, a bonding agent, and a perfluoroelastomer bonded to at least a portion of the metal alloy substrate via the bonding agent.

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: Provided are antibody drug conjugates that bind PRLR, in particular human PRLR, their methods of making, and uses thereof.

Abstract: A protocol designer for a test and measurement instrument, comprising an input to receive a signal, a memory configured to store the signal, an author configured to generate protocol definitions based on a user input, a debugger configured to output textual and visual decode results based on the protocol definitions and the signal, and a deployer configured to output a complied protocol definition file to the test and measurement instrument.

Abstract: A paper based overlay is provided. The overlay has a paper impregnated with a resin composition having an acrylic resin having a glass transition temperature in a range of from about ?20° C. to about 40° C. and a resin content from about 15 to about 35 wt. % based on the weight of the overlay. The acrylic composition may include wax in the amount of about 0.005 to about 3.5 wt. % based on the weight of the resin composition. A method of producing the overlay is also provided. The overlay is highly water and abrasion resistant with low volatile content.

Abstract: Described herein are fog harvesters having a vertical wire array and systems thereof. The fog harvesters described herein can be used to harvest liquid from the air, such as from fog. The fog harvesters can, in some aspects, have improved performance in one or more aspects as compared to fog harvesters having a mesh design.

Abstract: Organosilicon electrolytes exhibit several important properties for use in lithium carbon monofluoride batteries, including high conductivity/low viscosity and thermal/electrochemical stability. Conjugation of an anion binding agent to the siloxane backbone of an organosilicon electrolyte creates a bi-functional electrolyte. The bi-functionality of the electrolyte is due to the ability of the conjugated polyethylene oxide moieties of the siloxane backbone to solvate lithium and thus control the ionic conductivity within the electrolyte, and the anion binding agent to bind the fluoride anion and thus facilitate lithium fluoride dissolution and preserve the porous structure of the carbon monofluoride cathode. The ability to control both the electrolyte conductivity and the electrode morphology/properties simultaneously can improve lithium electrolyte operation.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.