Abstract: Apparatuses and methods for washing a plurality of fluid samples are disclosed herein. In an embodiment, a system for washing a plurality of fluid samples respectively located within a plurality of cuvettes includes a rotor configured to rotate the plurality of cuvettes about an axis, a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets, and a wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes.

Abstract: Apparatus (1) for generating hydrogen by means of electrolysis is described. The apparatus (1) includes a housing (2,3) adapted to contain an aqueous electrolyte, in use. A number of electrodes (19, 22) are located within the housing (1) The electrodes (19, 22) comprise a number of cathodes (19) and a number of anodes (22). The electrodes (19, 22) each have a first end portion (21, 18) and each of the electrodes (19, 22) are mounted on a first side wall (24) of the housing at the first end portion (21, 18), so that the first end portions (21, 18) are adapted to be coupled to an electrical power supply (104), in use. The electrodes (19, 22) are in the form of elongate members and are arranged in a linear array such that each anode (22) is separated from an adjacent anode (22) by a cathode (19) and each cathode (19) is separated from an adjacent cathode (19) by an anode (22).

Abstract: The present disclosure relates to isolation structures for semiconductor devices and, more particularly, to dual trench isolation structures having a deep trench and a shallow trench for electrically isolating integrated circuit (IC) components formed on a semiconductor substrate. The semiconductor isolation structure of the present disclosure includes a semiconductor substrate, a shallow trench isolation (STI) disposed over the semiconductor substrate, a deep trench isolation (DTI) with sidewalls extending from a bottom surface of the STI and terminating in the semiconductor substrate, a multilayer dielectric lining disposed on the sidewalls of the DTI, the multilayer dielectric lining including an etch stop layer positioned between inner and outer dielectric liners, and a filler material disposed within the DTI.

Abstract: This invention discloses an inertial-thruster architecture wherein active and passive damping techniques result in the redirection, absorption, neutralization, and/or enhancement of the effect of torque-induced precession on both oscillatory and rotary devices. These novel mechanical and methodological embodiments demonstrate that the redirection of precession during the appropriate phase of operations will achieve the objective of rectilinear movement when combined with the displacement of one or more precessable masses.

Abstract: A medical device is described having a handle, a shaft coupled to the handle and an end effector coupled to the shaft. In one embodiment, the device includes an ultrasonic transducer and is arranged so that ultrasonic or electrical energy can be delivered to a vessel or tissue to be treated. Various novel sensing circuits are described to allow a measure of the drive signal to be measured and fed back to a controller. An active fuse circuit is also described for protecting one or more batteries of the device from an over-current situation.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: A device (e.g., an application-specific integrated circuit chip) includes a memory module processing unit and an interface. The memory module processing unit is configured to receive an instruction to obtain values stored in one or more memory components and process the obtained values to return a processed result. The memory module processing unit is also configured to store the obtained values in a cache based on one or more criteria. The memory module processing unit is configured to be included on a computer memory module configured to be installed in a computer system. The interface is configured to communicate with the one or more memory components included on the computer memory module.

Abstract: A medical device is described having a handle, a shaft coupled to the handle and an end effector coupled to the shaft. In one embodiment, the device includes an ultrasonic transducer and is arranged so that ultrasonic or electrical energy can be delivered to a vessel or tissue to be treated. Various novel sensing circuits are described to allow a measure of the drive signal to be measured and fed back to a controller. An active fuse circuit is also described for protecting one or more batteries of the device from an over-current situation.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.

Abstract: An exemplary method of making packages includes advancing a web of connected bags to a position where an opening of the bag is below an engagement device and opening the engagement device. Additionally, the exemplary method includes blowing the opening of the bag to a partially opened configuration, and reverse indexing the web of connected bags so that a portion of the engagement device is disposed inside of the bag and a portion of the engagement device is disposed outside the bag. Subsequently, the exemplary method includes closing the engagement device so that the engagement device engages the bag and moving the engagement device to a position that causes the opening of the bag to have a rectangular shape.

Abstract: Certain embodiments of the invention provide a cyclic compound of formula I: wherein Pro, DPro, X1, X2, X3, X4, X5, and X6 are defined as described herein; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.

Abstract: Systems, methods, and computer programs for analyzing genetic sequence data is disclosed. In one aspect, the system can include one or more of a first integrated circuit, with each first integrated circuit forming a central processing unit (CPU) that is responsive to one or more software algorithms that are configured to instruct the CPU to perform a first set of genomic processing steps of a sequence analysis pipeline. Additionally, the system can include one or more second integrated circuits, with each second integrated circuit forming a field programmable gate array (FPGA). The FPGA can be configured by firmware to arrange a set of hardwired digital logic circuits to perform a second set of genomic processing stages of the sequence analysis pipeline, the set of hardwired digital logic circuits of each FPGA being arranged as a set of processing engines to perform the second set of genomic processing stages.

Abstract: A flow generator for delivering breathable gas to a patient includes a processor coupled with operation sensors and a user interface. The processor is programmed to generate at least one of time-based or event-based messages relating to at least one of flow generator operation, flow generator service, flow generator use, patient health, peripheral devices and services, patient treatment, and reminders. Time-based messages are generated at predetermined time intervals based on either time of use or elapsed time. The event-based messages are generated based on signals from the operation sensors. The user interface is configured to deliver the messages to at least one of a display, a flow generator service provider, the patient and a physician. By this system, operation of the flow generator is facilitated and enhanced.

Abstract: A medical device is described having a handle, a shaft coupled to the handle, an end effector coupled to the shaft and an ultrasonic transducer coupled to the end effector for delivering ultrasonic energy to tissue or a vessel to be treated. A drive circuit is provided for generating a drive signal that is applied to the ultrasonic transducer. In one embodiment, the drive circuit includes a resonant circuit and a controller that varies the period of the drive signal passed through the resonant circuit in order to control the power supplied to the ultrasonic transducer.

Abstract: Methods and apparatus that mix a plurality of individual capture reagents for diagnostic assays are described herein. In an embodiment, a system for optically analyzing a patient sample includes an automated immunochemistry analyzer storing a plurality of capture reagents and a plurality of paramagnetic particles, a user interface configured to allow a selection of a combination of two or more of the capture reagents, and a logic implementer configured to cause the automated immunochemistry analyzer to (i) mix together each capture reagent of the combination of two or more of the capture reagents; (ii) bind the mixture of the combination of two or more of the capture reagents to the paramagnetic particles; (iii) bind the patient sample to the bound mixture of the combination of two or more of the capture reagents; and (iv) optically analyze the patient sample.

Abstract: The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

Abstract: An unmachined cast body for a pipe fitting, the cast body includes a first body end and a second body end disposed opposite from the first body end, the cast body defining an axis extending from the first body end to the second body end, the cast body defining a midpoint between first body end and the second body end, a centerline of the cast body defined at the midpoint perpendicular to the axis, a first distance from the centerline to the first body end being equal to a second distance from the centerline to the second body end, an inner body surface defining a fitting bore extending through the cast body from the first body end to the second body end, and an outer body surface spaced from the inner body surface, the outer body surface defining a first frustoconical shape and a second frustoconical shape.

Abstract: One embodiment is an apparatus comprising an aircraft and an aerial network communications system associated with the aircraft. The network communications system may comprise an antenna physically connected to an outside surface of the aircraft; and a transceiver electrically connected to the antenna. The aerial network communications system receives signals from and transmits signals to an unmanned aerial vehicle (“UAV”) via a communications network comprising a control station and a plurality of airborne network nodes.