Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An adjustable prosthetic socket having adjustable features. For example, the socket can be heat moldable with one or more adjustable panels or members in communication with at least one tightening mechanism configured to reduce or adjust an inner circumference of the socket.

Abstract: A shower/commode wheeled chair adapted to be locatable over a commode, the shower/commode wheeled chair comprising a frame, a seat support portion, a front portion extending downwardly from the seat support portion, a back support, a shower/commode seat, wheels and a footrest coupled to the front portion.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Thermally broken fenestration systems are provided that improve performance characteristics or combinations thereof, including strength and thermal conductivity. Embodiments disclosed include one or more fenestration frame assemblies, each having an interior frame member and an exterior frame member. The interior frame members and exterior frame members are coupled together via a plurality of bridges distributed along the length of the respective fenestration frame assembly. The bridges provide structural rigidity, while providing a plurality of air gaps between interior frame member and the exterior frame member to provide a thermal break.

Abstract: The present disclosure relates to a gripping apparatus mounted to a robot arm for controllably placing an object on a surface. A gripper assembly supports a pair of gripping clamps which are configured to grip and release the object. The gripper assembly is mounted to the robot arm via a connector body. A sensor is configured to either measure a relative movement between the gripper assembly and the connector body, or to measure a force between the gripper assembly and the connector body. A controller is configured to stop the robot arm when the sensor indicates the measured relative movement or measured force exceeds a predefined threshold.

Abstract: Disclosed herein are various systems, sub-system, and methods for the manufacture of a wall module for using in building a modular construction unit, e.g., for using in building residential homes, commercial offices, educational or service facilities, etc. using a substantially entirely automated modular construction technique. According to the disclosure herein, the resulting wall module includes an internal wall frame including wall studs attached between a top plate and a bottom plate, with, in some embodiment, one or more framing sub-assemblies attached therein to define openings through the wall module. The wall frame has suitable panel members the respective surfaces thereof corresponding to the interior and exterior surfaces of the modular construction unit. The wall frames, when completely assembled, can be transported to be assembled with other constituent components of the modular construction unit to complete the manufacture of the modular construction unit.

Abstract: A stander device with improvements to facilitate and/or make more convenient the adjustment and/or repositioning of various elements of the stander device for sizing and comfort of a patient/user, as well as making the folding, storage, and transportation thereof more convenient.

Abstract: A suspended sleeve assembly includes a suspension stand and a compression sleeve. An upper portion of the compression sleeve is attached onto the suspension stand, but a lower portion of the compression sleeve is unattached from the suspension stand. The suspended sleeve assembly can also include a support stand. The suspended sleeve assembly can be used to shape a prosthetic socket. The compression sleeve applies a circumferential pressure onto the prosthetic socket as the prosthetic socket is being inserted into the compression sleeve as a patient steps into the compression sleeve and applies at least a portion of body weight to the compression sleeve. The prosthetic socket can be heated and shaped by hand, so that it fits the residual limb of the patient. The suspended sleeve assembly can also be used to shape other prosthetic components, such as a negative plaster cast.

Abstract: Automated systems and methods of manufacturing truss elements for use in modular construction units can include stations, or steps, for forming angled webs, upright webs, and truss chords for use in the truss elements, transferring such angled webs, upright webs, and truss chords onto an assembly jig in a configuration corresponding to the truss element being manufactured, rigidly interconnecting, via nail plates, the angled webs, the upright webs, and the truss chords to form a finished truss element, and unloading the finished truss element from the assembly jig.

Abstract: A system for modeling the evolution of a system overtime using an advection-based process is provided. The system continuously evolves a probability density function (“PDF”) for a characteristic of a characteristic of the state of the system and its time-varying parameters. The PDF is evolved based on advection by solving an advection partial differential equation that is based on a system model of the system. The system model has time-varying parameters for modeling the characteristic of the state of the system. The system uses the continuously evolving PDF to make predictions about the characteristic of the state of the system.

Abstract: Systems and methods for user authentication are disclosed. An example method includes receiving a request for access to a first secured service, the request corresponding to a first user, determining whether or not the request for access is valid, in response to determining that the request for access is valid, determining whether or not the first user has successfully performed a secondary authentication within a predetermined time period of the request for access, and in response to determining that the first user has successfully performed the secondary authentication within the predetermined time period of the valid request for access, providing the first user with access to the secured service.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Embodiments disclosed herein include methods of depositing a metal oxo photoresist using dry deposition processes. In an embodiment, the method comprises forming a first metal oxo film on the substrate with a first vapor phase process including a first metal precursor vapor and a first oxidant vapor, and forming a second metal oxo film over the first metal oxo film with a second vapor phase process including a second metal precursor vapor and a second oxidant vapor.

Abstract: A modular elevator system has a pit module, one or more shaft modules that are attachable to the pit module and/or to an adjacent shaft module, and a cap module that is attachable to an uppermost shaft module. The pit module, the shaft modules, and the cap module are each pre-fabricated and transported to a site at which a building is under construction for assembly top of the pit module, the remaining shaft modules are secured sequentially on top of each other, and the cap module is secured on top of the uppermost shaft module.

Abstract: A system and method for assembling framing assemblies for use as ceiling or floor structures of modular building units using automation are disclosed. The framing assemblies include trusses that are attached at the lateral edges thereof by a joist including at least one layer of dimensional lumber to form a substantially rigid framework. Cover panels are positioned over and attached to an inner surface of the framing assembly.

Abstract: A connector system for interconnecting vertically adjacent and/or laterally adjacent modular units of a building constructed from such modular units assembled rigidly together includes connectors that are rigidly attached to the modular units. These connectors are able to rigidly interlock with each other so that, when the connectors of adjacent modular units are interlocked with each other, the adjacent modular units are also rigidly attached to each other. The connectors include sliding alignment features that ensure that resist lateral displacement of laterally adjacent modular units and also ensure proper alignment of vertically-engaging retention features that resist vertical displacement of vertically adjacent modular units.

Abstract: In one aspect, at a client computing device, a set of web browser analytics events generated by user web browsing activity is enqueued. Responsive to the enqueued set of web browser analytics events satisfying a condition, prompting for consent to perform data analytics is performed. Responsive to the prompting, input is received corresponding to a received consent to perform at least some of the data analytics. Based on the received consent, at least a part of the enqueued set of web browser analytics events is uploaded to a server for use in performing the at least some of the data analytics.

Abstract: A computer monitors a status of grid devices using sensor measurements. Sensor data is clustered using a predefined grouping distance value to define one or more sensor event clusters. A plurality of monitored devices is clustered using a predefined clustering distance value to define one or more asset clusters. A location is associated with each monitored device of the plurality of monitored devices. A distance is computed between each sensor event cluster and each asset cluster. When the computed distance is less than or equal to a predefined asset/sensor distance value for a sensor event cluster and an asset cluster, an asset identifier of the asset cluster associated with the computed distance is added to an asset event list. For each asset cluster included in the asset event list, an asset location of an asset is shown on a map in a graphical user interface presented in a display.

Abstract: A system for aggregating a user's web browsing data which may include cookies placed on a user's computing device from various websites. The system receives authorization from a user to retrieve cookie and other data associated with the user. The system then accesses cookie data and personal data associated with the user. In some embodiments, the aggregation system communicates with websites that placed the cookie data on the user's computer to determine one or more characteristics of the user based on the cookie data (which may be understandable only by the placing website). The system may then provide the user's aggregated data or a portion thereof to requesting entities. The user may have access to a user interface which provides information about the user's aggregated data and allows the user to determine how much information to share with requesting entities.