Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the Coagulation Factor X (F10) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of an F10 gene and to methods of treating or preventing an F10-associated disease, e.g., a disorder associated with thrombosis, in a subject.

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region; a detector configured to detect whether samples corresponding to any of the two or more par

Abstract: Apparatus comprises a data encoder configured to derive, from an array of sample values, sample range flags each indicative of whether one or more sample values of the array of sample values lie in a predetermined range of sample values, the data encoder being configured in a first encoding mode to encode the array of sample values, at least in part, by encoding the sample range flags to an output data stream; a predictor configured to predict the state of a group of the sample range flags for a given array of sample values, the group being at least a subset of the sample range flags; and a comparator configured to compare the predicted state of the group of sample range flags with the actual state of the respective sample range flags for the given array of sample values; the data encoder being configured, in response to the comparator, to encode the given array of samples values in a second encoding mode in which the encoder is configured to encode to the output data stream a predetermined number of indicato

Abstract: Apparatus comprises video data decoder circuitry configured to decode an input video data stream, the video data decoder being responsive to parameter data associated with the input video data stream, the parameter data indicating a profile selected from a plurality of profiles, each profile defining a decoding attribute comprising one or more of a bit depth and a chrominance subsampling format; detector circuitry configured to detect constraint data associated with the input video data stream, the constraint data defining a difference between a decoding attribute applicable to the input video data stream and the decoding attribute defined by the profile indicated by the parameter data, in which the constraint data is configured to indicate a zero difference of the decoding attribute by a zero value of the constraint data; and control circuitry configured to control the video data decoder to decode the input video data stream to generate a decoded video data stream having a decoding attribute defined by the e

Abstract: The present disclosure is directed to methods of immunization and methods for generating antibodies using compositions comprising cationic lipids and polynucleotide molecules, such as polyribonucleotide molecules, e.g., mRNA, which code for immunogens (e.g., a target protein or a fragment thereof).

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated ocular diseases.

Abstract: Apparatus comprises video data decoder circuitry configured to decode an input video data stream, the video data decoder being responsive to parameter data associated with the input video data stream, the parameter data indicating a profile selected from a plurality of profiles, each profile defining a decoding attribute comprising one or more of a bit depth and a chrominance subsampling format; detector circuitry configured to detect constraint data associated with the input video data stream, the constraint data defining a difference between a decoding attribute applicable to the input video data stream and the decoding attribute defined by the profile indicated by the parameter data, in which the constraint data is configured to indicate a zero difference of the decoding attribute by a zero value of the constraint data; and control circuitry configured to control the video data decoder to decode the input video data stream to generate a decoded video data stream having a decoding attribute defined by the e

Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting MYOC, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of MYOC.

Abstract: A method of encoding successive data items comprises storing history data for encoded data items, the history data indicating one or more aspects of encoding the encoded data items; encoding a given data item by a first encoding technique comprising encoding a series of zero or more data sets, each data set representing a respective range of values of the data items and selecting the series of data sets from a plurality of candidate data sets in dependence upon (i) a number of previously encoded data sets; and (ii) the history data applicable to a given property of the given data item; and encoding any remaining value of the given data item, the remaining value being an amount by which the given data item exceeds a maximum value which can be encoded by the first encoding technique, by a second encoding technique different to the first encoding technique.

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the complement component C3 gene and methods of using such iRNA agents for treating or preventing C3-associated ocular diseases or C3-associated neurodegenerative diseases.

Abstract: An image encoding apparatus comprises a controller configured to select, from a set of prediction directions, a set of candidate prediction directions as a subset of the set of prediction directions, for a current image region of a current image in dependence upon one or more properties of a group of reference samples of the current image applicable to the current image region; and an intra-image predictor configured to predict samples of the current image region with respect to one or more of the group of reference samples of the same image according to a prediction direction between the current sample and a reference position amongst the reference samples; in which the intra-image predictor is configured to select the prediction direction for the current image region from the set of candidate prediction directions.

Abstract: Apparatus comprises a video data decoder; and a coded picture buffer to buffer successive portions of an input video data and provide a portion to the video data decoder for decoding, the coded picture buffer having a coded picture buffer size; the video data decoder being responsive to parameter data associated with the input video data, the parameter data indicating, for a given input video data, an encoding level selected from a plurality of encoding levels, each level defining at least a maximum luminance picture size, a minimum compression ratio and a maximum value of the coded picture buffer size; in which for each encoding level of the plurality of encoding levels, the maximum value of the coded picture buffer size is greater than or equal to the number of bits required to represent a picture at the maximum luminance picture size when encoded according to the minimum compression ratio.

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region; a detector configured to detect whether samples corresponding to any of the two or more par

Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting VEGF-A, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of VEGF-A.

Abstract: A video data encoding method for encoding an array of video data values comprises the steps of: frequency-transforming the video data values according to a frequency transform, to generate an array of frequency-transformed values by a matrix-multiplication process using a transform matrix having a data precision of fourteen bits, the frequency transform being a discrete cosine transform; defining a 64×64 transform matrix M64 for a 64×64 DCT transform, the matrix M64 being defined by the accompanying FIGS. 10a-10e and 11; for an N×N transform where N is 2, 4, 8 or 16, subsampling the 64×64 transform matrix M64 to select a subset of N×N values, the subset MN[x][y] of values being defined by: MN[x][y]=M64[x][(2(6-log2(N)))y] for x,y=0 . . . (N?1).

Abstract: An apparatus including a video data decoder configured to decode an input video data stream, the video data decoder being responsive to a parameter value associated with the input video data stream, the parameter value indicating an encoding level selected from a plurality of encoding levels, each encoding level defining at least a maximum luminance picture size and a maximum luminance sample rate, the encoding level defining a first numerical component and a second numerical component, the second numerical component being a numerical value greater than or equal to zero, in which for encoding levels having a second numerical component of zero, the first numerical component increases monotonically with increasing maximum luminance picture size, and the second component varies with the maximum luminance sample rate; the parameter value being a numeric encoding of the encoding level.

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction selected from a set of available prediction directions, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; and an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and the reference samples; in which for at least some of the candidate prediction operations: the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region, the intra-image predictor being configured to derive the predi

Abstract: A method of encoding video data values, the method including selectively encoding, via circuitry, a high bit depth control flag and, when the high bit depth control flag is set to indicate high bit depth operation, selectively encoding an extended precision flag to indicate at least extended precision operation of a spatial frequency transform stage and encoding the video data values according to a mode of operation defined by the encoded high bit depth control flag and, when encoded, the extended precision flag.

Abstract: An image encoding apparatus comprises a selector configured to select a prediction operation, for prediction of samples of a current region of a current image with respect to one or more of a group of reference samples, from a set of candidate prediction operations, at least some of which define, as an intra-image prediction operation, a prediction direction between a current sample to be predicted and a group of reference samples in the same image; and an intra-image predictor configured to derive predicted samples of a current image region from reference samples of the same image in response to selection, by the selector, of an intra-image prediction operation for the current image region; in which: the current region comprises at least a subset of a current coding tree unit (CTU) in an array of CTUs; the group of references samples is disposed, with respect to the current image region at one or more predetermined sides of the current image region; and the selector is configured to inhibit the selection of