Abstract: A hardware decryption processor operates, when power is applied to a programmable logic device, to read an encrypted configuration program, to decrypt the encrypted configuration program using a first secret configuration key stored in a register, and to configure a programmable array of logic elements with the configuration program. The programmable array when configured with the configuration program operates to read the encrypted configuration program from a non-volatile store, to decrypt the configuration program using the first secret configuration key, which was provided with the configuration program, to generate a second secret key, to adapt the configuration program by inserting the second secret key into the configuration program, to re-encrypt the adapted configuration program using the first secret configuration key, and to replace the configuration program with the adapted and encrypted configuration program in the non-volatile store.

Abstract: An apparatus for embedding a watermark in an audio signal, the apparatus comprising: an input operable to receive the audio signal; a watermark adapting unit operable to receive the watermark from a watermark generating unit and adapt the profile of the frequency spectrum of the watermark to correspond to the profile of the frequency spectrum of the input audio signal, and watermark embedding means operable to embed the adapted watermark in the audio signal, the watermark embedding means including a watermark gain amplifier operable to apply a gain to the watermark before the watermark is embedded in the audio signal in accordance with a gain signal generated by a watermark gain value generator, wherein the watermark gain value generator is operable to adjust the gain applied to the watermark, the gain being determined in accordance with the presence of component of at least one peak having an amplitude above a threshold is described

Abstract: An encoding data processing apparatus generates a video material item marked copy by embedding a payload data word into the video material item. The video material item includes plural video frames. A code word generator generates a water mark code word from the payload data word and reads data representing the water mark code word into a shuffle data store. A shuffle processor generates pseudo randomly at least one address within an address space of the shuffle data store for each video frame and reads data representing part or parts of the water mark code word out from the data store at locations identified by the pseudo randomly generated address. A data embedding processor receives the video material item and embeds the data representing the part or parts of the water mark code word read out from the shuffle data store for each frame into a corresponding frame of the video material item.

Abstract: A material distribution apparatus, comprising a material server including a data introduction processor operable to introduce data into material to be distributed with the effect that the introduced data is at least difficult to perceive in the material, and a material impairment processor operable to introduce a reversible impairment into the material. A communications network distributes the impaired material to at least one client processor which includes an impairment reversing processor operable to reverse the impairment of the material to produce client restored material.

Abstract: A method of transferring information signals representing still images, video audio and/or other data comprises sending, the information signals to a recipient apparatus or “viewer” 10 from a server 2 via a network 12. Data indicative of whether or not further data is to be embedded in the information signals is also sent either with the signals or separately. The further data is embedded in the information signals at the viewer 10 in dependence upon the indicative data. The further data is perceptible in the information signals as to degrade them.

Abstract: An encoding data processing apparatus generates a marked version of an audio signal provided on an audio channel. The marked copy is generated by embedding data representative of a payload data word into the audio signal. The encoding data processing apparatus comprises a code word generator operable to generate a water mark code word from the payload data word and to read data representing the water mark code word into a shuffle data store. A shuffle processor is operable to generate pseudo randomly at least one address within an address space of the shuffle data store for each predetermined period and to read data representing part or parts of the water mark code word out from the data store at locations identified by the randomly generated address, and a data embedding processor operable to receive the audio signal and to embed the data representing the part or parts of the water mark code word read out from the shuffle data store into the audio signal for each predetermined period.

Abstract: The invention relates to the determination of the genomic structure of HERG which is a gene associated with long QT syndrome. The sequences of the 15 intron/exon junctions has been determined and this information is useful in devising primers for amplifying and sequencing across all of the exons of the gene. This is useful for determining the presence or absence of mutations which are known to cause long QT syndrome. Also disclosed are many new mutations in HERG which have been found to be associated with long QT syndrome.

Abstract: A method of embedding data in material comprises the steps of: embedding data in original material to produce data embedded material; removing the watermark from the data embedded material to produce recovered material; comparing the original and recovered material to determine the differences and locations of differences therebetween; and storing the said locations and corrections which correct the said differences. A method of removing the data embedded in the material, comprises the steps of: removing the data from the material to produce recovered material; deriving the said corrections and locations from the said store; and using the corrections to correct the recovered material at the said locations.

Abstract: An image processing apparatus is operable to embed data into an image. Images such as those generated from an inter-laced scan may comprise a frame of image data, the frame comprising first and second image fields. The image processing apparatus comprises a combining processor operable to introduce the data to be embedded into at least one of the first and second fields of the image frame. As such a likelihood of a perceivable effect of the embedded data on the image may be reduced, because the images are viewed as a frame. The embedded data may also have an increased likelihood of being detected because some processing may effect the image frame more then the fields of the image. The combining processor may be operable to represent the data to be embedded in a transform domain form, and, in combination with a transform processor, combine the data to be embedded with the first and/or second fields with the image in a transform domain form or a spatial domain form.

Abstract: Compositions and methods for increasing proliferation and/or de-differentiation of postmitotic mammalian cardiomyocytes are disclosed to slow, reduce, or prevent the onset of cardiac damage. In addition, the methods and compositions of the invention can used to produce de-differentiated cardiomyocytes, which can then be used in tissue grafting, implantation or transplantation. The invention is based, in part, on the discovery that postmitotic mammalian cardiomyocytes can proliferate as a result of targeted disruption of p38 MAP kinase. p38 inhibition with optional growth factor stimulation can induce cytokinesis in adult cardiomyocytes.

Abstract: An image processing apparatus is operable to embed data into an image. The apparatus comprises a combining processor operable to introduce the data into a transform domain representation providing a plurality of sub-bands divided by spatial frequency components, and, in combination with a transform processor, to combine the data with the image in one of a transform domain form, the transform processor generating a transform domain form of the image, the data being combined with the image by the combining processor in the transform domain, and the transform processor generating a spatial domain representation of the combined image and data, or a spatial domain form of the image, the transform processor generating a spatial domain representation of the transform domain data, the data being combined with the image by the combining processor in the spatial domain.

Abstract: Material is represented by transform coefficients represented by digital numbers. A method of perceptibly watermarking the material comprises the steps of: changing representations of the said numbers according to an invertible algorithm without changing the number of bits in the said numbers; and encoding the changed n bit numbers to effect compression encoding of the material.

Abstract: A spatial domain using image produced by a source is combined with watermark data Ri to produce a spatial domain watermarked image. The watermarked image is produced by an embedder according to equation: Ci?=Ci+?. Ri, where Ci and Ci? are wavelet transform coefficients of the image, and ? is a scaling factor. ? is chosen so that the watermark is imperceptible in the image and to resist removal of the watermark by unauthorized processing. It is desirable that a has the smallest value which achieves that. If ? is too big the watermark is perceptible in the image. If ? is too small the mark may not survive processing of the image.

Abstract: An apparatus for detecting and recovering data embedded in information material, the data having been embedded in the material in a transform domain representation by arranging for the data to modulate a predetermined data sequence to form modulated data and combining the modulated data with the material. The apparatus includes a transform processor operable to transform the material into the transform domain representation, and a correlation processor operable to correlate transform domain data symbols bearing the modulated data with a reproduced version of the predetermined data sequence to form a correlation output signal and to recover the embedded data from the correlation output signal. The correlation processor is operable to repeat the correlation for transform domain data symbols and data symbols of the predetermined data sequence for each of a plurality of start positions in the transform domain.

Abstract: An apparatus for embedding data in information material, the data being a plurality of data items each having a different relative importance. The apparatus comprises an encoding processor operable to encode each of said data items, and a combining processor operable to combine said encoded data items with said information material. The information material provides a limited data embedding capacity, as a result for example of the limited bandwidth of the information material itself. Each of the data items are encoded and embedded to the effect that a proportion of the limited data embedding capacity is allocated to the encoded data items in accordance with the relative importance of these data items. As such, for example, an amount of error protection given to each of the data items can be arranged in accordance with the importance of the data items, whilst still satisfying the limited data embedding capacity.

Abstract: Elastin, the main component of arterial extracellular matrix, was thought to have a purely structural role. Consistent with this view, elastin hemizygous mice maintain arterial extensibility by increasing the number of elastic lamellae during development. However, mice lacking elastin die of obstructive arterial pathology. This pathology results from subendothelial proliferation and reorganization of smooth muscle, cellular changes similar to those observed in atherosclerosis. Thus, elastin is a molecular determinant of arterial morphogenesis and likely plays a central role in vascular disease. Mice which are heterozygous and null for the elastin gene have been developed. These mice are extremely useful for screening for drugs useful for treating persons with atherosclerosis, hypertension, SVAS or other vascular diseases.

Abstract: The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.

Abstract: Long QT Syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on electrocardiogram and presence of syncope, seizures and sudden death. Five genes have been implicated in Romano-Ward syndrome, the autosomal dominant form of LQTS. These genes are KVLQT1, HERG, SCN5A, KCNE1 and KCNE2. Mutations in KVLQT1 and KCNE1 also cause the Jervell and Lange-Nielsen syndrome, a form of LQTS associated with deafness, a phenotypic abnormality inherited in an autosomal recessive fashion. Mutational analyses were used to screen 262 unrelated individuals with LQTS for mutations in the five defined genes. A total of 134 mutations were observed of which eighty were novel.

Abstract: A method of transferring information signals representing still images, video audio and/or other data comprises sending, the information signals to a recipient apparatus or “viewer” 10 from a server 2 via a network 12. Data indicative of whether or not further data is to be embedded in the information signals is also sent either with the signals or separately. The further data is embedded in the information signals at the viewer 10 in dependence upon the indicative data. The further data is perceptible in the information signals as to degrade them.

Abstract: A material distribution apparatus, comprising a material server including a data introduction processor operable to introduce data into material to be distributed with the effect that the introduced data is at least difficult to perceive in the material, and a material impairment processor operable to introduce a reversible impairment into the material. A communications network distributes the impaired material to at least one client processor which includes an impairment reversing processor operable to reverse the impairment of the material to produce client restored material.