Abstract: The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the Coagulation Factor X (F10) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of an F10 gene and to methods of treating or preventing an F10-associated disease, e.g., a disorder associated with thrombosis, in a subject.

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region; a detector configured to detect whether samples corresponding to any of the two or more par

Abstract: Apparatus comprises a data encoder configured to derive, from an array of sample values, sample range flags each indicative of whether one or more sample values of the array of sample values lie in a predetermined range of sample values, the data encoder being configured in a first encoding mode to encode the array of sample values, at least in part, by encoding the sample range flags to an output data stream; a predictor configured to predict the state of a group of the sample range flags for a given array of sample values, the group being at least a subset of the sample range flags; and a comparator configured to compare the predicted state of the group of sample range flags with the actual state of the respective sample range flags for the given array of sample values; the data encoder being configured, in response to the comparator, to encode the given array of samples values in a second encoding mode in which the encoder is configured to encode to the output data stream a predetermined number of indicato

Abstract: The present disclosure is directed to methods of immunization and methods for generating antibodies using compositions comprising cationic lipids and polynucleotide molecules, such as polyribonucleotide molecules, e.g., mRNA, which code for immunogens (e.g., a target protein or a fragment thereof).

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated ocular diseases.

Abstract: Apparatus comprises video data decoder circuitry configured to decode an input video data stream, the video data decoder being responsive to parameter data associated with the input video data stream, the parameter data indicating a profile selected from a plurality of profiles, each profile defining a decoding attribute comprising one or more of a bit depth and a chrominance subsampling format; detector circuitry configured to detect constraint data associated with the input video data stream, the constraint data defining a difference between a decoding attribute applicable to the input video data stream and the decoding attribute defined by the profile indicated by the parameter data, in which the constraint data is configured to indicate a zero difference of the decoding attribute by a zero value of the constraint data; and control circuitry configured to control the video data decoder to decode the input video data stream to generate a decoded video data stream having a decoding attribute defined by the e

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the complement component C3 gene and methods of using such iRNA agents for treating or preventing C3-associated ocular diseases or C3-associated neurodegenerative diseases.

Abstract: An image encoding apparatus comprises a selector configured to select a prediction operation, for prediction of samples of a current region of a current image with respect to one or more of a group of reference samples, from a set of candidate prediction operations, at least some of which define, as an intra-image prediction operation, a prediction direction between a current sample to be predicted and a group of reference samples in the same image; and an intra-image predictor configured to derive predicted samples of a current image region from reference samples of the same image in response to selection, by the selector, of an intra-image prediction operation for the current image region; in which: the current region comprises at least a subset of a current coding tree unit (CTU) in an array of CTUs; the group of references samples is disposed, with respect to the current image region at one or more predetermined sides of the current image region; and the selector is configured to inhibit the selection of

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction selected from a set of available prediction directions, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; and an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and the reference samples; in which for at least some of the candidate prediction operations: the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region, the intra-image predictor being configured to derive the predi

Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the complement component C3 gene (C3). The invention also relates to methods of using such RNAi agents to inhibit expression of a C3 gene and to methods of preventing and treating a C3-associated disorder, e.g., cold agglutinin disease (CAD), warm autoimmune hemolytic anemia, and paroxysmal nocturnal hemoglobinuria (PNH), lupis nephritis (LN), bullous pemphigoid, pemphigus, e.g., pemphigus vulgaris (PV) and pemphigus foliaceus (PF), and C3 glomerulopathy.

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated ocular diseases.

Abstract: Control apparatus to control operation of a data buffer to which data items are written according to a write pointer which advances in position in response to an input data item rate and from which data items are read according to a read pointer which advances in position in response to an output data item rate, comprises: a detector configured to detect an occupancy difference between a current buffer occupancy and a target buffer occupancy, in which the current buffer occupancy represents a difference between the read and write pointers; an output data item interpolator configured to interpolate a data item at an interpolated data buffer location displaced by a read offset displacement from a data buffer location pointed to by the read pointer; and output control circuitry configured, in response to a current occupancy difference exceeding a threshold occupancy difference, to change the read pointer from an initial read pointer to a target read pointer by a change amount so as to reduce the occupancy differ

Abstract: A point-of-care system with a diagnostic tool and a base station with a display and in communication with the diagnostic tool is described. Used in diagnosing health conditions for a tissue under analysis, the diagnostic tool includes a handle and a head portion. The head portion includes a speculum and optical spectroscopy (OS) data acquisition components positioned within the head portion. The OS data acquisition components are configure to (i) emit light toward the tissue under analysis, (ii) receive light reflected at least in part from the tissue under analysis based on the emitted light, and (iii) determine reflectance spectra associated with the received light. Either the diagnostic tool or a base station includes analytic components configured to (i) generate diagnostic metrics including characteristics of the reflectance spectra and (ii) compare these characteristics to data associated with characteristics of known reflectance spectra associated healthy and/or unhealthy tissue of patients.

Abstract: An image decoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; and an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region.

Abstract: Apparatus comprises an image data encoder to encode a current image region of an image, the image data encoder being operable in at least two modes of operation; a controller to control a mode of operation of the image data encoder in dependence upon the encoded data for the current image region meeting a predetermined criterion; and prediction circuitry configured to predict, from one or more properties of one or more image regions other than the current image region, whether the encoded data for the current image region will meet the predetermined criterion.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the APP gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an APP-associated disease or disorder, such as cerebral amyloid angiopathy (CAA) and early onset familial Alzheimer disease (EOFAD or eFAD), using such dsRNAi agents and compositions.

Abstract: Apparatus comprises video data decoder circuitry configured to decode an input video data stream, the video data decoder being responsive to parameter data associated with the input video data stream, the parameter data indicating a profile selected from a plurality of profiles, each profile defining a decoding attribute comprising one or more of a bit depth and a chrominance subsampling format; detector circuitry configured to detect constraint data associated with the input video data stream, the constraint data defining a difference between a decoding attribute applicable to the input video data stream and the decoding attribute defined by the profile indicated by the parameter data, in which the constraint data is configured to indicate a zero difference of the decoding attribute by a zero value of the constraint data; and control circuitry configured to control the video data decoder to decode the input video data stream to generate a decoded video data stream having a decoding attribute defined by the e

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region; a detector configured to detect whether samples corresponding to any of the two or more par

Abstract: An image encoding apparatus comprises a selector configured to select, from a set of candidate prediction operations each defining at least a prediction direction, a prediction operation for prediction of samples of a current region of a current image, the current region comprising an array of two or more rows and two or more columns of samples; an intra-image predictor configured to derive predicted samples of the current region with respect to one or more of a group of reference samples of the same image in dependence upon a prediction direction, defined by the selected prediction operation, between a current sample to be predicted and a reference position amongst the reference samples; in which, for at least some of the candidate prediction operations, the group of reference samples comprises two or more parallel linear arrays of reference samples disposed at different respective separations from the current region; a detector configured to detect whether samples corresponding to any of the two or more par

Abstract: Apparatus comprises a video data decoder configured to decode an input video data stream, the video data decoder being responsive to a parameter value associated with the input video data stream, the parameter value indicating an encoding level selected from a plurality of encoding levels, each encoding level defining at least a maximum luminance picture size and a maximum luminance sample rate; the encoding level defining a first numerical component and a second numerical component, the second numerical component being a numerical value greater than or equal to zero; in which: for encoding levels having a second numerical component of zero, the first numerical component increases monotonically with increasing maximum luminance picture size; second component varies with the maximum luminance sample rate; the parameter value being a numeric encoding of the encoding level a first predetermined constant multiplied by the first numerical component plus a second predetermined constant multiplied by the second nume