Patents by Inventor Mark Smith

Mark Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P14-Kinase Inhibitors with Anti-Cancer Activity
    Publication number: 20220062243
    Abstract: Methods of treating a subject for cancer using a PI4-kinase inhibitor are provided. Also provided are methods of inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation. The PI4-kinase inhibitor can be a compound that is a 5-aryl or heteroaryl-thiazole, e.g., as described herein. In certain embodiments, the PI4-kinase inhibitor is a substituted 2-amino-5-phenylthiazole or substituted 2-amino-5-pyridylthiazole compound. The subject compounds may be formulated or provided to a subject in combination with one or more additional anti-cancer agents. Use of PI4-kinase inhibitors in methods of reducing cellular proliferation and methods of treatment is provided in a variety of cancer cells and cancer subjects.
    Type: Application
    Filed: January 9, 2020
    Publication date: March 3, 2022
    Inventors: Jeffrey S. GLENN, Mark SMITH, Edward PHAM
  • Augmenting missing values in historical or market data for deals
    Patent number: 11257110
    Abstract: One embodiment provides a method for augmenting missing values in historical or market data for deals. The method comprises receiving information relating to a set of deals. For any service included in one or more deals of the set of deals but not included in one or more other deals of the set of deals, the method further comprises augmenting, for any or all of the one or more other deals that does not include the service, one or more missing values for the service with one or more recommended values based on a recommendation algorithm. The service may be at any service level of a hierarchy of services.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: February 22, 2022
    Assignee: International Business Machines Corporation
    Inventors: Mari A. Fukuda, Kugamoorthy Gajananan, Shun Jiang, Aly Megahed, Taiga Nakamura, Mark A. Smith
  • SYSTEM AND METHOD FOR MAKING MICROSPHERES AND EMULSIONS
    Publication number: 20220047999
    Abstract: Various examples of systems and methods for making microspheres, microparticles, and emulsions are provided. In one example, a system and method for forming microspheres comprises: pumping a dispersed phase liquid and a continuous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase liquid and continuous phase liquid to a high shear environment within the impeller pump's pump chamber. In another example, a system and method for forming an emulsion comprises: pumping a dispersed phase liquid and an inner aqueous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase and the inner aqueous phase to a high shear environment within the impeller pump's pump chamber.
    Type: Application
    Filed: October 5, 2021
    Publication date: February 17, 2022
    Applicant: OAKWOOD LABORATORIES, LLC
    Inventors: Tracy Richey, Rachel Galaska, Samantha Cramer, Ford Minaghan, Cory Mahnen, Mark Smith, Fadee Mondalek
  • SYSTEMS AND METHODS FOR DELIVERY OF GEL EMBOLICS
    Publication number: 20220039801
    Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.
    Type: Application
    Filed: July 15, 2021
    Publication date: February 10, 2022
    Inventors: Joseph CONNOLLY, Gary Pederson, Mary-Claire Anderson, Patrick Haverkost, David Raab, Mark Smith
  • PI-Kinase Inhibitors with Anti-Infective Activity
    Publication number: 20220017507
    Abstract: Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-heteroaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 20, 2022
    Inventors: Jeffrey S. Glenn, Michael A. Gelman, Brandon Tavshanjian, Kevan Shokat, Ingrid Choong, Mark Smith
  • Persistent memory architecture
    Patent number: 11226869
    Abstract: Techniques are provided for implementing a persistent memory storage tier to manage persistent memory of a node. The persistent memory is managed by the persistent memory storage tier at a higher level within a storage operating system storage stack than a level at which a storage file system of the node is managed. The persistent memory storage tier intercepts an operation targeting the storage file system. The persistent memory storage tier retargets the operation from targeting the storage file system to targeting the persistent memory. The operation is transmitted to the persistent memory.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: January 18, 2022
    Assignee: NetApp, Inc.
    Inventors: Ananthan Subramanian, Ram Kesavan, Matthew Fontaine Curtis-Maury, Mark Smith
  • SYNCHRONIZED PITCH AND TIMING CUES IN A HEARING PROSTHESIS SYSTEM
    Publication number: 20220008732
    Abstract: Presented herein are binaural hearing prosthesis systems that are configured to provide a recipient with pitch cues at both ears, while preserving/retaining binaural timing cues.
    Type: Application
    Filed: October 26, 2020
    Publication date: January 13, 2022
    Inventors: Brett Anthony Swanson, Zachary Mark Smith
  • ANGULAR POSITION SENSOR AND ASSOCIATED METHOD OF USE
    Publication number: 20220011138
    Abstract: An angular position sensor comprising two planar excitation coils forming a substantially circular interior area and two planar sensing coils positioned within a minor sector of the substantially circular interior area. Each of the two planar sensing coils comprises a clockwise winding portion and a counter-clockwise winding portion. The angular position sensor further comprises a substantially circular rotatable inductive coupling element positioned in overlying relation to the two planar sensing coils and separated from the two planar sensing coils by an airgap, wherein the substantially circular rotatable inductive coupling element comprises three, substantially evenly space, sector apertures.
    Type: Application
    Filed: July 13, 2020
    Publication date: January 13, 2022
    Inventors: Ganesh Shaga, Kevin Mark Smith, JR., Hwangsoo Choi, Sudheer Puttapudi
  • Angular position sensor and associated method of use
    Patent number: 11221236
    Abstract: An angular position sensor comprising two planar excitation coils forming a substantially circular interior area and two planar sensing coils positioned within a minor sector of the substantially circular interior area. Each of the two planar sensing coils comprises a clockwise winding portion and a counter-clockwise winding portion. The angular position sensor further comprises a substantially circular rotatable inductive coupling element positioned in overlying relation to the two planar sensing coils and separated from the two planar sensing coils by an airgap, wherein the substantially circular rotatable inductive coupling element comprises three, substantially evenly space, sector apertures.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: January 11, 2022
    Assignee: Microchip Technology Inc.
    Inventors: Ganesh Shaga, Kevin Mark Smith, Jr., Hwangsoo Choi, Sudheer Puttapudi
  • Axle assembly having a multi-speed countershaft transmission
    Patent number: 11207976
    Abstract: An axle assembly having a countershaft transmission. The countershaft transmission may operatively connect an electric motor to a drive pinion. The countershaft transmission may have a first countershaft subassembly that is rotatable about a first countershaft axis and a second countershaft subassembly that is rotatable about a second countershaft axis.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: December 28, 2021
    Assignee: ArvinMeritor Technology, LLC
    Inventors: Chetankumar Ghatti, Rodrigo Soffner, Christopher Keeney, Mark Smith
  • Axle assembly having a multi-speed transmission
    Patent number: 11209072
    Abstract: An axle assembly having a countershaft transmission. The countershaft transmission may operatively connect a rotor shaft of an electric motor to a drive pinion that may be rotatable about a drive pinion axis. The electric motor and the countershaft transmission may be positioned on opposite sides of a differential assembly.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: December 28, 2021
    Assignee: ArvinMeritor Technology, LLC
    Inventors: Chetankumar Ghatti, Rodrigo Soffner, Christopher Keeney, Mark Smith
  • Banana plant named 'QCAV-4'
    Publication number: 20210400858
    Abstract: A new banana cultivar ‘QCAV-4’ is provided that, when under significant disease pressure, remains largely free from infection by Fusarium wilt tropical race 4 (TR4). In the absence of such significant disease pressure, ‘QCAV-4’ appears to be essentially phenotypically identical to the wild type parent Cavendish Grand Nain. This includes in relation to immature and mature plant characteristics, fruit characteristics, and yield.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 23, 2021
    Applicant: Queensland University of Technology
    Inventors: James Dale, Robert Harding, Harjeet Khanna, Anthony James, Jennifer Kleidon, Mark Smith, Upendra Shekhawat
  • 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
    Publication number: 20210369755
    Abstract: Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the inhibition of HCV polymerase.
    Type: Application
    Filed: February 12, 2021
    Publication date: December 2, 2021
    Inventors: Mark SMITH, Klaus G. KLUMPP
  • ENPP1 Inhibitors and Their Use for the Treatment of Cancer
    Publication number: 20210369747
    Abstract: Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both.
    Type: Application
    Filed: September 7, 2018
    Publication date: December 2, 2021
    Inventors: Lingyin LI, Mark SMITH, Kelsey Erin SHAW, Jacqueline Ann CAROZZA, Volker BOEHNERT
  • SYSTEMS, METHODS, AND DEVICES FOR IMPLEMENTING A SMART CONTRACT ON A DISTRIBUTED LEDGER TECHNOLOGY PLATFORM
    Publication number: 20210377225
    Abstract: In some embodiments, systems, methods, and devices disclosed herein are directed to implementations of one or more smart contracts deployed on a distributed ledger technology (DLT) platform. In some embodiments, implementation of one or more specific smart contracts and/or private data sharing technologies on a DLT platform can provide frameworks and/or solutions to generate a smart UCC platform that facilitates submission and tracking of Uniform Commercial Code (UCC) filings on a distributed ledger or blockchain platform. In some embodiments, implementation of one or more specific smart contracts and/or private data sharing technologies on a DLT platform can provide frameworks and/or solutions to generate a smart company platform for controlling, managing, and/or communicating company documents and/or communications on a distributed ledger or blockchain platform.
    Type: Application
    Filed: May 13, 2021
    Publication date: December 2, 2021
    Inventors: Mark Smith, Anush Vijayaraghavan, Evan Wagner, Yiqun Yin
  • AXLE ASSEMBLY HAVING AN ELECTRIC MOTOR MODULE AND METHOD OF MANUFACTURE
    Publication number: 20210376686
    Abstract: An axle assembly and a method of manufacture. The axle assembly may include a differential carrier and a bearing support wall. The differential carrier may be made of a first material. The bearing support wall may be mounted to the differential carrier and may be made of a second material. The second material may have a greater stiffness than the first material.
    Type: Application
    Filed: May 9, 2019
    Publication date: December 2, 2021
    Applicant: ArvinMeritor Technology, LLC
    Inventors: Mark Smith, Dhanapal Vittala Raya
  • APICAL INNER EAR STIMULATION
    Publication number: 20210370050
    Abstract: An apical cochlear implant comprises an apical electrode assembly in combination with a basilar electrode assembly. The apical cochlear implant is configured to stimulate a cochlear of a recipient via the apical electrode assembly in combination with the basilar electrode assembly.
    Type: Application
    Filed: April 9, 2020
    Publication date: December 2, 2021
    Inventors: Christopher Joseph Long, Zachary Mark Smith
  • Dialysis systems with a suspended reservoir
    Patent number: 11187572
    Abstract: A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: November 30, 2021
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Barry Neil Fulkerson, Joe Fazio, Alec Huang, Brian Thomas Kelly, Tam Nolan, Mark Smith
  • plant named ‘CIFZ0082’
    Patent number: PP33879
    Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0082’ particularly distinguished by its medium size plant with round mound plant habit, a medium to large size daisy flower, pink/lavender flower color and a natural season response in early September.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: January 18, 2022
    Assignee: Syngenta Crop Protection AG
    Inventor: Mark A. Smith
  • plant named ‘CIFZ0084’
    Patent number: PP33981
    Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0084’ particularly distinguished by its small size plant with round mound plant habit, a small size decorative flower, purple flower color and a natural season response in mid September.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: March 1, 2022
    Assignee: Syngenta Crop Protection AG
    Inventor: Mark A. Smith