Abstract: A method, comprising, fitting an electrical stimulating device to the recipient, the electrical stimulating device including electrodes implanted in the recipient, the electrical stimulating device being a multipolar electrical stimulating device, wherein the fitting includes simultaneously applying multipolar stimulation to the recipient via the electrodes based on at least two different stimulation channels of the electrical stimulating device.

Abstract: One embodiment provides a method for estimating unit price reduction of services in a new in-flight deal using data of historical deals and market reference deals cost structures. The method includes receiving a detailed cost structure for historical information, market deals information, services quantity information and deals metadata for a first year. For each service: peer deals to the in-flight deal are selected based on the detailed cost structure; missing cost data values in the peer deals are augmented; unit cost reduction values for the peer deals estimated; the unit cost reduction for the in-flight deal from each year in total contract years to a next year without a last contract year are estimated; and a total cost for the in-flight deal for all years in the total contract years beyond the first year are estimated.

Abstract: Presented herein are techniques for enhancing a hearing prosthesis recipient's perception of multiple frequencies present in received sound signals. The hearing prosthesis is configured to extract a plurality of frequencies from the received sound signals and to use the plurality of frequencies to modulate the amplitudes of different stimulation pulse sequences that are to be delivered to the recipient via different stimulation channels. The hearing prosthesis may also adapt a stimulation resolution of the stimulation pulse sequences when delivering the modulated stimulation pulses sequences to the recipient.

Abstract: Various examples of systems and methods for making microspheres, microparticles, and emulsions are provided. In one example, a system and method for forming microspheres comprises: pumping a dispersed phase liquid and a continuous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase liquid and continuous phase liquid to a high shear environment within the impeller pump's pump chamber. In another example, a system and method for forming an emulsion comprises: pumping a dispersed phase liquid and an inner aqueous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase and the inner aqueous phase to a high shear environment within the impeller pump's pump chamber.

Abstract: The present specification discloses a dialysis system having a reservoir module with a reservoir housing defining an internal space, a surface located within the internal space for supporting a container that contains dialysate, and a conductivity sensor located within the internal space, where the conductivity sensor has a coil, a capacitor in electrical communication with the coil, and an energy source in electrical communication with the circuit.

Abstract: Techniques are provided for implementing a file system format for persistent memory. A node, comprising persistent memory, receives an operation comprising a file identifier and file system instance information. A list of file system info objects are evaluated to identify a file system info object matching the file system instance information. An inofile, identified by the file system info object as being associated with inodes of files within an instance of the file system targeted by the operation, is traversed to identify an inode matching the file identifier. If the inode comprises an indicator that the file is tiered into the persistent memory, then the inode it utilized to facilitate execution of the operation upon the persistent memory. Otherwise, the operation is routed to a storage file system tier for execution by a storage file system upon storage associated with the node.

Abstract: Techniques are provided for implementing a persistent memory storage tier to manage persistent memory of a node. The persistent memory is managed by the persistent memory storage tier at a higher level within a storage operating system storage stack than a level at which a storage file system of the node is managed. The persistent memory storage tier intercepts an operation targeting the storage file system. The persistent memory storage tier retargets the operation from targeting the storage file system to targeting the persistent memory. The operation is transmitted to the persistent memory.

Abstract: A system and method for additive manufacturing are provided. The system includes a structure defining a chamber for manufacturing parts via additive manufacturing. A powder metal applicator is configured to deposit layers of powder metal material to build a part on a build platform. A laser source is configured to direct one or more laser beams onto each layer of powder metal material to fuse the powder metal material, wherein metal condensate is created by the laser beam(s) contacting the powder metal material. An element spaced apart from the layers of powder material has a temperature different than the chamber temperature, so that the element is configured to attract or repel the metal condensate by virtue of the temperature differential between the element and the chamber. The method includes using the element having the different temperature to attract or repel the metal condensate within the chamber.

Abstract: A genus of compounds encompassed by formula (III) and their use is disclosed: The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.

Abstract: One embodiment provides a method comprising receiving historic peer deals relating to at least one service, and a baseline and cost percentage estimation for each service. Historic peer cost data for each service is clustered to form at least one cluster. Each cluster includes similar unit costs, and has an assigned label. A classification model is trained based on each baseline received, each cost percentage estimation received, and each assigned label. For each assigned label, a corresponding probability distribution is computed based on the classification model. For each service of a new client solution, an assigned label for the service is predicted based on the classification model, and, based on a probability distribution corresponding to the assigned label predicted, transforming an initial range of historic peer cost data relating to the service into a narrower range for use in estimating a cost of the service with improved accuracy.

Abstract: A method of at least partially fitting a hearing prosthesis device to a recipient, including obtaining access to a sensory prosthesis that has been used to evoke a sensory percept using a first focusing regime for a temporal period corresponding to at least acclimation to the first focusing regime and adjusting a control setting of the prosthesis to increase focusing relative to that which is the case with respect to the first focusing regime, wherein the action of adjusting the control setting includes purposely adjusting the control setting to have focusing that is effectively less focused than a maximum focus possible.

Abstract: The compound 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-5-ol: and its use are disclosed. The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

Abstract: A method, including providing stimulation to a recipient of a prosthesis, such as a hearing prosthesis, such as an implantable prosthesis, such as a cochlear implant, wherein the stimulation is provided at temporal locations associated with sleep of the recipient, and the stimulation is at least one of part of a measurement method or an auditory training method.

Abstract: Presented herein are techniques for adapting/transitioning operation of a medical prosthesis, such as an auditory prosthesis, from a first or initial group of settings to a second or target group of settings. The adaptation in the operation of the medical prosthesis from the first group of settings to the second group of settings occurs over a period of time and in a series of individualized (recipient-specific) incremental steps. That is, the adaptation process occurs in incremental steps that are set based on attributes/characteristics of the recipient of the specific medical prosthesis so that the adaptation is made as unobtrusive to the recipient as possible.

Abstract: A closure for a liquid container includes a base portion and a top portion. The base portion includes a top deck and an outer skirt extending from an outer end of the top deck in a lower direction away from the top deck. The outer skirt comprises a fastening means to interconnect the closure to the container neck. The top deck further has a spout extending in an upper direction away from the top deck. The top portion includes an annular base interconnectable to the base portion and a cover having an outer wall. At least one tamper element extends from the annular base in the upper direction above the annular base along the outer wall but spaced a distance apart from said outer wall. The tamper element is also initially interconnected to the outer wall by a predetermined breaking linkage.

Abstract: Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-hetereoaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0076’ particularly distinguished by its medium to large size plant with very round plant habit, a medium size decorative flower (2.0 inch), yellow flower color and a natural season response mid-September.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0078’ particularly distinguished by its medium size plant with round mound plant habit, a small size decorative flower (1.5 inch), yellow flower color and a natural season response early October.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0088’ particularly distinguished by its medium size plant with mound plant habit, a medium size decorative flower, pink/lavender flower color with darker flower center and a natural season response late September/early October.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0086’ particularly distinguished by its medium size plant with round plant habit, a medium to large size daisy, scarlet red flower color and a natural season response in early October.