Patents by Inventor Mark Spyvee

Mark Spyvee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydantoin containing deoxyuridine triphosphatase inhibitors
    Patent number: 10570098
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: February 25, 2020
    Assignee: CV6 Therapeutics (NI) Limited
    Inventors: Mark Spyvee, Pravin S. Shirude
  • Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
    Patent number: 10570100
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: February 25, 2020
    Assignees: University of Southern California, CV6 Therapeutics (NI) Limited
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • Hydantoin containing deoxyuridine triphosphatase inhibitors
    Patent number: 10562860
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: February 18, 2020
    Assignee: CV6 Therapeutics (NI) Limited
    Inventors: Mark Spyvee, Pravin S. Shirude
  • Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
    Patent number: 10544105
    Abstract: Provided herein are dUTPase inhibitors of Formula (I), compositions comprising such compounds and methods of using such compounds and compositions
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: January 28, 2020
    Assignee: CV6 THERAPEUTICS (NI) LIMITED
    Inventors: Mark Spyvee, Pravin S. Shirude
  • HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20200017481
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: January 16, 2020
    Inventor: Mark Spyvee
  • Inhibitors of the Notch transcriptional activation complex and methods for use of the same
    Patent number: 10501413
    Abstract: Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: December 10, 2019
    Assignees: UNIVERSITY OF MIAMI, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Anthony J. Capobianco, Alex Mackerell, Jr., Mark Spyvee
  • HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20190330210
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: October 31, 2019
    Inventors: Mark Spyvee, Robert D. Ladner
  • AMINO SULFONYL COMPOUNDS
    Publication number: 20190330158
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: October 31, 2019
    Inventor: Mark Spyvee
  • NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20190276410
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: September 12, 2019
    Inventors: Mark Spyvee, Robert D. Ladner
  • 6-MEMBERED URACIL ISOSTERES
    Publication number: 20190270756
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: November 21, 2017
    Publication date: September 5, 2019
    Inventors: Mark Spyvee, Michael Lewis
  • HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
    Publication number: 20190151312
    Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
    Type: Application
    Filed: October 8, 2015
    Publication date: May 23, 2019
    Inventors: Shripad Bhagwat, Bing Wang, Gregory R. Luedtke, Mark Spyvee
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20180334431
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: July 7, 2016
    Publication date: November 22, 2018
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING CYCLOPROPANO LINKAGE
    Publication number: 20180201586
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 19, 2018
    Inventors: Mark Spyvee, Pravin S. Shirude
  • DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE
    Publication number: 20180194740
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 12, 2018
    Inventors: Robert D. Ladner, Mark Spyvee, Pravin S. Shirude
  • HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20180194736
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Inventors: Mark Spyvee, Pravin S. Shirude
  • HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
    Publication number: 20180186737
    Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 5, 2018
    Inventors: Mark Spyvee, Pravin S. Shirude
  • INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME
    Publication number: 20180086700
    Abstract: Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 29, 2018
    Inventors: Anthony J. Capobianco, Alex Mackerell, JR., Mark Spyvee
  • Pharmaceutical composition
    Patent number: 9000024
    Abstract: The present invention provides compounds of Formula I: along with pharmaceutical compositions containing the same, and methods of use thereof in subjects in need of treatment.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: April 7, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Mark Spyvee, Takashi Satoh, Jonathan Eric Carlson
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20140309174
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 16, 2014
    Applicant: Eisai Co., Ltd
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • PHARMACEUTICAL COMPOSITION
    Publication number: 20140155452
    Abstract: The present invention provides compounds of Formula I: along with pharmaceutical compositions containing the same, and methods of use thereof in subjects in need of treatment.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Mark Spyvee, Takashi Satoh, Jonathan Eric Carlson