Patents by Inventor Mark Spyvee

Mark Spyvee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDANTOIN COMPOUNDS
    Publication number: 20100113446
    Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.
    Type: Application
    Filed: January 5, 2010
    Publication date: May 6, 2010
    Inventors: Brian M. Gallagher, JR., Eric Carlson, Qian Chen, Heather Davis, Shawn Schiller, Christina Shaffer, Mark Spyvee, Nancy Wong
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20100063095
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 11, 2010
    Inventors: James J. KOWALCZYK, Galina KUZNETSOV, Shawn SCHILLER, Boris M. SELETSKY, Mark SPYVEE, Hu YANG
  • Hydantoin compounds
    Patent number: 7666875
    Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: February 23, 2010
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Brian M. Gallagher, Jr., Eric Carlson, Qian Chen, Heather Davis, Shawn Schiller, Christina Shaffer, Mark Spyvee, Nancy Wong
  • IMIDAZOAZEPINONE COMPOUNDS
    Publication number: 20090233906
    Abstract: The invention relates to compounds of formula (I): along with pharmaceutical compositions containing the same and methods of use thereof.
    Type: Application
    Filed: May 23, 2007
    Publication date: September 17, 2009
    Inventors: Francis Fang, Shawn Schiller, Boris Seletsky, Mark Spyvee
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7585976
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: September 8, 2009
    Assignee: Eisai Co., Ltd.
    Inventors: Silvio A. Campagna, Francis G. Fang, James J. Kowalczyk, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • ENANTIOMERICALLY ENRICHED IMIDAZOAZEPINONE COMPOUNDS
    Publication number: 20090197867
    Abstract: The present invention provides an enantiomerically pure compound of Formula I: along with pharmaceutical formulations containing the same and methods of use thereof.
    Type: Application
    Filed: November 14, 2008
    Publication date: August 6, 2009
    Inventors: Mark Spyvee, Christina J. Shaffer, Boris M. Seletsky, Shawn Schiller, Jia Liu, Xiang-Yi Li, Qian Chen, Roch Boivin
  • COMPOUNDS AND METHODS FOR TREATING TOLL-LIKE RECEPTOR 2-RELATED DISEASES AND CONDITIONS
    Publication number: 20090186855
    Abstract: The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
    Type: Application
    Filed: April 1, 2009
    Publication date: July 23, 2009
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Jesse Chow, Fabian Gusovksy, Lynn Hawkins, Mark Spyvee
  • Compounds and methods for treating toll-like receptor 2-related diseases and conditions
    Patent number: 7550501
    Abstract: The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: June 23, 2009
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jesse Chow, Fabian Gusovksy, Lynn Hawkins, Mark Spyvee
  • IMIDAZOAZEPINONE COMPOUNDS
    Publication number: 20090131405
    Abstract: The invention relates to compounds of formula I: along with pharmaceutical compositions containing the same and methods of use thereof for the treatment of autoimmune disease.
    Type: Application
    Filed: May 24, 2007
    Publication date: May 21, 2009
    Inventors: Francis Fang, Shawn Schiller, Boris Seletsky, Mark Spyvee
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 7528152
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: May 5, 2009
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin Derivatives and Uses Thereof
    Publication number: 20080108820
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: September 22, 2004
    Publication date: May 8, 2008
    Inventors: Silvio A. Campagna, Francis G. Fang, James J. Kowalczyk, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Deazapurines and uses thereof
    Publication number: 20080103137
    Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases.
    Type: Application
    Filed: September 28, 2007
    Publication date: May 1, 2008
    Inventors: Jane Daun, Heather Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, Andre Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Publication number: 20080051434
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 2, 2007
    Publication date: February 28, 2008
    Applicant: EISAI CO., LTD.
    Inventors: James Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris Seletsky, Mark Spyvee, Hu Yang
  • Deazapurines and uses thereof
    Patent number: 7314936
    Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: January 1, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Jane Daun, Heather A. Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, André Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris M. Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions
    Publication number: 20070167409
    Abstract: The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
    Type: Application
    Filed: April 6, 2007
    Publication date: July 19, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Jesse Chow, Fabian Gusovksy, Lynn Hawkins, Mark Spyvee
  • Compounds and methods for treating Toll-like receptor 2-related diseases and conditions
    Patent number: 7202234
    Abstract: The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: April 10, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: Jesse Chow, Fabian Gusovksy, Lynn Hawkins, Mark Spyvee
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7192972
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: March 20, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hydantoin compounds
    Publication number: 20060270696
    Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.
    Type: Application
    Filed: May 26, 2006
    Publication date: November 30, 2006
    Inventors: Brian Gallagher, Eric Carlson, Qian Chen, Heather Davis, Shawn Schiller, Christina Shaffer, Mark Spyvee, Nancy Wong
  • Macrocyclic compounds useful as pharmaceuticals
    Publication number: 20060247448
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
    Type: Application
    Filed: March 7, 2003
    Publication date: November 2, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Roch Boivin, Kenichi Chiba, Jesse Chow, Hong Du, Yoshihito Eguchi, Masanori Fujita, Masaki Goto, Fabian Gusovsky, Jean-Christophe Harmanage, Atsushi Inoue, Yimin Jiang, Megumi Kawada, Takatoshi Kawai, Yoshiyuki Kawakami, Akifumi Kimura, Makoto Kotake, Yoshikazu Kuboi, Charles-Andre Lemelin, Xiang-Yi Li, Tomohiro Matsushima, Yoshiharu Mizui, Kenzo Muramoto, Hideki Sakurai, Yong-Chun Shen, Hiroshi Shirota, Mark Spyvee, Isao Tanaka, John Wang, Satoshi Yamamoto, Naoki Yoneda
  • Hemiasterlin derivatives and uses thereof
    Publication number: 20060154872
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: January 26, 2006
    Publication date: July 13, 2006
    Inventors: Silvio Campagna, Francis Fang, James Kowalczyk, Shawn Schiller, Boris Seletsky, Mark Spyvee, Hu Yang