Abstract: A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A process for preparing a catalyst component, including: contacting a compound R9zMgX2?z wherein R9 is aromatic, aliphatic or cyclo-aliphatic group containing up to 20 carbon atoms, X is a halide, and z is larger than 0 and smaller than 2, with an alkoxy- or aryloxy-containing silane compound to give a first intermediate reaction product; contacting the first intermediate reaction product with at least one activating compound selected electron donors, compounds of formula M(OR10)v-w(OR11)w, wherein M is Ti, Zr, Hf, Al or Si, and M(OR10)v-w(R11)w wherein M is Si, each R10 and R11, independently, represent an alkyl, alkenyl or aryl group, v is the valency of M, v is 3 or 4, and w is less than v, to give a second intermediate reaction product; and contacting the second intermediate reaction product with a halogen-containing Ti-compound, a monoester as activating agent, and a 1,3-diether as an internal electron donor.

Abstract: A catalyst composition comprising a monoester, the compound represented by formula (I) as an internal electron donor, and optionally an additional internal electron donor selected from a group consisting of diesters and diethers, wherein: R1, R2, R3, R4, R5 and R6 are hydrogen, straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, R7 is a straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, and R8 is an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms. Also described is a process for preparing the polymerization catalyst composition, a polymerization catalyst system comprising the catalyst composition, a co-catalyst and optionally an external electron donor; and use of the catalyst system for polymerization of olefins.

Abstract: Gravel pack composition containing gravel and a water-in-oil emulsion including (a) an organic continuous phase comprising 0.1 to 5 vol % of the emulsion of non-ionic or cationic surfactant and 0.25 to 3 vol % of the emulsion of sorbitan ester; (b) a dispersed aqueous phase comprising 0.05 to 3 vol % of the emulsion of a partial ester of a polyol with at least one C6 to C22 fatty acid and at least one of an acid, acid precursor, and a chelating agent; and (c) a density control agent. The fluid can display a delayed break of up to about 72 hours to enable clean-up of mud cake.

Abstract: The present invention relates to a catalyst composition comprising the compound represented by the Fischer projection of formula (I) as an internal electron donor, (I) wherein: R1, R2, R3, R4, R5 and R6 are the same or different and are independently selected from a group consisting of hydrogen, straight, branched and cyclic alkyl and aromatic substituted and unsubstituted hydrocarbyl having 1 to 20 carbon atoms; R7 is selected from a group consisting of straight, branched and cyclic alkyl and aromatic substituted and unsubstituted hydrocarbyl having 1 to 20 carbon atoms; and R8 is selected from a group consisting of aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; N is nitrogen atom; O is oxygen atom; and C is carbon atom. The present invention also relates to a process for preparing said polymerization catalyst composition and to a polymerization catalyst system comprising said catalyst composition, a cocatalyst and optionally an external electron donor.

Abstract: Methods and systems of dynamically updating content in e-mail messages are described. In some embodiments, an e-mail message is generated. The e-mail message comprises existing content viewable within an e-mail client and is configured to initiate a modification of the existing content within the e-mail message by the e-mail client subsequent to the e-mail message being downloaded by the e-mail client. The modification of the existing content is viewable within the e-mail client. The generated e-mail message is sent to an e-mail account from which a user can view the e-mail message within the e-mail client. In some embodiments, the e-mail message is further configured to cause the e-mail client to obtain new content from a remote server for use in the modification of the existing content within the e-mail message.

Abstract: A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A series of benzimidazole derivatives, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A power supply unit (130) for powering at least one gradient coil (128) of a magnetic resonance (MR) examination system (110) with a main magnet (114) having, in at least one state of operation, a substantially static magnetic field strength, and with an MR measurement signal bandwidth, the power supply unit (130) comprising: a switched-mode power converter (134) for powering the at least one gradient coil (128), comprising at least one switching member provided to switch between a conducting state configuration and an essentially non-conducting state configuration at a first fundamental switching frequency (fSW); a pulse control unit (132) designed to provide switching pulses at the first fundamental switching frequency (fSW) for controlling the switching of the at least one switching member; wherein, upon triggering by a trigger signal (142), the pulse control unit (132) is provided to change the first fundamental switching frequency (fSW) to at least a second fundamental switching frequency (fSW).

Abstract: A modified release formulation of lacosamide.

Abstract: The invention relates to a new catalyst component for the polymerization of olefins comprising a compound of formula CyLMZp, wherein M is a Group 4-6 metal, Z is an anionic ligand, p is the number of anionic ligands, Cy is a mono- or poly-substituted cyclopentadienyl-type ligand and L is a guanidinate ligand of the formula wherein: each A is independently selected from nitrogen or phosphorus and R, R1, R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl, silyl and germyl residues, substituted or not with one or more halogen, amido, phosphido, alkoxy, or aryloxy radicals. The invention also relates to a catalyst system for the polymerization of olefins and a process for the polymerization of at least one olefin having 2 to 20 carbon atoms.

Abstract: The present invention relates to a power supply system (311) for supplying current to a gradient coil (303) of a magnetic resonance imaging system (100), the power supply system (311) comprising: an electrical power supply (309) to supply a first voltage to a gradient amplifier (307) for driving the gradient coil, the gradient amplifier output being connected to the gradient coil (303); an energy buffer having an input connected to the electrical power supply (309), the energy buffer being configured to supply second voltage to the gradient amplifier (307), the energy buffer being in parallel to the gradient amplifier (307) and the electrical power supply (309), the energy buffer comprising a voltage converter (313) configured to control the second voltage as to compensate for a variation in the first voltage resulting from the driving of the gradient coil (303).

Abstract: The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is an amidinate-containing ligand of formula (1), wherein the amidinate-containing ligand is covalently bonded to the titanium via the imine nitrogen atom, Sub1 is a substituent, which comprises a group 14 atom through which Sub1 is bonded to the imine carbon atom, Sub2 is a substituent, which comprises a nitrogen atom, through which Sub2 is bonded to the imine carbon atom, and Cy is a mono- or polysubstituted cyclopentadienyl-type ligand, wherein the one or more substituents of Cy are selected from the group consisting of halogen, hydrocarbyl, silyl and germyl residues, optionally substituted with one or more halogen, amido, phosphido, alkoxy, or aryloxy residues.

Abstract: Methods and systems of navigating between a mobile application and a mobile browser are described. In some embodiments, it is determined that an action has been performed within a mobile application on a mobile device to launch a mobile browser on the mobile device. An identifier for the mobile application is then registered with an operating system of the mobile device, and a navigation element of the mobile browser is associated with the registered identifier. The mobile application can then be re-launched in response to receiving an indication of a selection of the navigation element within the mobile browser. In some embodiments, the identifier is a uniform resource identifier (URI). In some embodiments, associating the navigation element of the mobile browser with the registered identifier comprises modifying a browser history of the mobile browser. In some embodiments, the navigation element is a selectable back button.

Abstract: Methods and systems of controlling the actions of a mobile browser to accommodate situations where a mobile application corresponding to a selected link is installed, as well as not installed, on a mobile device are described. In some embodiments, a selectable link associated with a mobile application is displayed within a mobile resource on a mobile device. A user selection of the selectable link is received. Content associated with the selectable link is displayed on the mobile device in response to receiving the user selection. If the mobile application is installed on the mobile device, then mobile application content associated with the mobile application is caused to be displayed within the mobile application on the mobile device. If the mobile application is not installed on the mobile device, then mobile browser content associated with the mobile application is caused to be displayed within the mobile browser.

Abstract: Methods and systems of optimizing e-mail for mobile devices are described. In some embodiments, an e-mail message is caused to be displayed within an e-mail client on a mobile device. The e-mail message comprises a selectable link corresponding to a website action that can be performed on a website. A user on the mobile device is enabled to cause a performance of an e-mail action corresponding to the website action via the e-mail client without navigating to the website, such as via a new e-mail message generated within the e-mail client. A mobile link configured to cause the performance of the action via the e-mail client can be included in the e-mail message. A CSS pseudo-element can be included in CSS rules for the e-mail message. The CSS pseudo-element can be configured to generate mobile content associated with the mobile link.

Abstract: A method and apparatus for delivering power to a hybrid vehicle is disclosed. The apparatus includes an apparatus for delivering power to a hybrid vehicle, the hybrid vehicle including a powertrain having a power take-off coupling, the powertrain including an engine and a transmission. The apparatus includes an electric motor operable to generate a torque, the motor being coupled to transmit a starting torque through the power take-off of the powertrain for starting the engine.

Abstract: The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is a guanidinate-containing ligand of the formula (I) wherein each A is independently selected from nitrogen or phosphorous and R, R1, R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl, silyl and germyl residues, substituted or not with one or more halogen, amido, phosphido, alkoxy, or aryloxy radicals, and Cy is a mono- or polysubstituted cyclopentadienyl-type ligand, wherein the one or more substituents of Cy are selected from the group consisting of halogen, hydrocarbyl, silyl and germyl residues, optionally substituted with one or more halogen, amido, phosphido, alkoxy, or aryloxy residues.

Abstract: The invention relates to a catalyst system for the polymerization of olefms comprising a metal complex of formula and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is a guanidinate-containing ligand of the formula wherein each A is independently selected from nitrogen or phosphorous and R, R 1,R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl, silyl and germyl residues, substituted or not with one or more halogen, amido, phosphido, alkoxy, or aryloxy radicals, and the activating cocatalyst is a boron compound represented by the general formula BR4R5R6, wherein B is a boron atom in the trivalent valence state and R4, R5 and R6 are individually selected from the group consisting of halogen atom, hydrocarbyl, halogenated hydrocarbyl, substituted silyl, alkoxy or di-substituted amino residue.

Abstract: Technology, alternative to money, for enabling equitable trade between users. The technology embodies chiralkine money and chiralkine property rights created as vectors through chiralkine contracts made by a recorder that maintains an open register and a trading pair of two users.