Abstract: A method and apparatus for customizing tool paths. A reference tool path is identified for a tool based on an expected shape for a surface of an object. Offset data is generated for a plurality of sample points identified for use in evaluating the surface of the object. The offset data identifies a difference between the expected shape for the surface of the object and an actual shape of the surface of the object. The reference tool path is modified using the offset data to form a modified tool path for the tool.

Abstract: A reversible ladder-mounted support and tray has a bracket designed to be removably affixed to the combination of a rail of a ladder and over a rung just adjacent to the rail. A first fitting is provided that overlies the rail and a second fitting overlies the rung. Concerning the second fitting overlying the rung, in fact, two such fittings are also provided that are essentially back-to-back. In this way, the support may be removably installed on either of the opposed rails of the ladder so that the support can extend laterally to either side of the ladder. Attached to the first fitting designed to overlie the rail is an elongated rod to which is mounted an elongated tube or sleeve having a split and a locking mechanism. The split allows the tube to slide freely over the rod and the locking mechanism may be engaged to narrow the split to lock the position and orientation of the tube thereon.

Abstract: A modified release formulation of lacosamide suitable for once-daily administration.

Abstract: A modified release formulation of lacosamide.

Abstract: Embodiments relate generally to a pump control system for a pressure sewer installation. The system comprises a controller arranged to control supply of power to a pump of the pressure sewer installation. The controller is arranged to receive an output signal from a sensor in a fluid reservoir of the pressure sewer installation, the output signal being indicative of a measured fluid level in the fluid reservoir. A memory is accessible to the controller and is arranged to store operation information pertaining to operation of the pressure sewer installation. A wireless transceiver is in communication with the controller to allow the controller to communicate with a remote server over a communications network.

Abstract: A game in which the moves players can make simulate both the symmetric and antisymmetric couplings of muscle pairs that accompany co-ordinated movement of the two sides of the human body, and in which each player's move comprises two components, one beneficial to the player and the other beneficial to the player(s) opponents (herein called chiralkines); a kit for playing the game; an electronic gaming device for use in playing the game; left- and right handed money and left- and right-handed property rights for use in a game or commerce; and apparatuses adapted for use with these.

Abstract: The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is an amidinate-containing ligand of formula (1), wherein the amidinate-containing ligand is covalently bonded to the titanium via the imine nitrogen atom, Sub1 is a substituent, which comprises a group 14 atom through which Sub1 is bonded to the imine carbon atom, Sub2 is a substituent, which comprises a nitrogen atom, through which Sub2 is bonded to the imine carbon atom, and Cy is a mono- or polysubstituted cyclopentadienyl-type ligand, wherein the one or more substituents of Cy are selected from the group consisting of halogen, hydrocarbyl, silyl and germyl residues, optionally substituted with one or more halogen, amido, phosphido, alkoxy, or aryloxy residues.

Abstract: The invention relates to a new catalyst component for the polymerization of olefins comprising a compound of formula CyLMZp, wherein M is a Group 4-6 metal, Z is an anionic ligand, p is the number of anionic ligands, Cy is a mono- or poly-substituted cyclopentadienyl-type ligand and L is a guanidinate ligand of the formula wherein: each A is independently selected from nitrogen or phosphorus and R, R1, R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl, silyl and germyl residues, substituted or not with one or more halogen, amido, phosphido, alkoxy, or aryloxy radicals. The invention also relates to a catalyst system for the polymerization of olefins and a process for the polymerization of at least one olefin having 2 to 20 carbon atoms.

Abstract: The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein: —M is titanium; —Cy is a cyclopentadienyl-type ligand; —D is a diene; —L is an amidinate-containing ligand of formula (1), wherein the amidinate-containing ligand is covalently bonded to the titanium via the imine nitrogen atom, Sub, is a substituent, which comprises a group 14 atom through which Sub1 is bonded to the imine carbon atom, Sub2 is a substituent, which comprises a nitrogen atom, through which Sub2 is bonded to the imine carbon atom, and the activating cocatalyst is a boron compound represented by the general formula BR1R2R3, wherein B is a boron atom in the trivalent valence state and R1, R2 and Ware individually selected from the group consisting of halogen atom, hydrocarbyl, halogenated hydrocarbyl, substituted silyl, alkoxy or di-substituted amino residue.

Abstract: A reversible ladder-mounted support and tray has a bracket designed to be removably affixed to the combination of a rail of a ladder and over a rung just adjacent to the rail. A first fitting is provided that overlies the rail and a second fitting overlies the rung. Concerning the second fitting overlying the rung, in fact, two such fittings are also provided that are essentially back-to-back. In this way, the support may be removably installed on either of the opposed rails of the ladder so that the support can extend laterally to either side of the ladder. Attached to the first fitting designed to overlie the rail is an elongated rod to which is mounted an elongated tube or sleeve having a split and a locking mechanism. The split allows the tube to slide freely over the rod and the locking mechanism may be engaged to narrow the split to lock the position and orientation of the tube thereon.

Abstract: A device for the purification of water, has the following components: (a) a storage tank (10) for retention of the purified water; (b) a feed pipe (15), leading from the water to be purified to the storage tank (10); (c) a reactor (4) for anodic oxidation of the water arranged within the feed pipe (15); (d) the storage tank (10) having a redox sensor (5) for measuring the redox potential; and (e) water supply from the feed pipe (15) into the storage tank (10) is performed discontinuously.

Abstract: A gravel pack composition comprising i) a water-in-oil emulsion comprising: a) an organic continuous phase comprising 0.1 to 5 vol % of the emulsion of non-ionic or cationic surfactant and 0.25 to 3 vol % of the emulsion of sorbitan ester; b) a dispersed aqueous phase comprising 0.05 to 3 vol % of the emulsion of a partial ester of a polyol with at least one C6 to C22 fatty acid and at least one of an acid, acid precursor, and a chelating agent; and c) a density control agent; and ii) gravel. The fluid can display a delayed break of up to about 72 hours to enable clean-up of mud cake.

Abstract: The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance.

Abstract: The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C2-20 olefin in the presence of an ionic catalyst, comprising an organometallic compound and an activator, and optionally a scavenger.

Abstract: A method of creating patent rights for a business entity in a drug candidate for clinical development, in which an expert in pharmaceutical science and an expert in pharmaceutical patent law collaborate in a risk-free environment to identify and protect drug candidates, and a kit useful in the method.

Abstract: The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms associated with the risk of thiopurine resistance or intolerance.

Abstract: The present invention relates to specific pentamethine cyanine azo complex dye compounds and their use as dyes in optical layers for optical data recording, preferably for optical data recording using a laser with a wavelength from 630 to 670 nm. The invention further relates to an optical layer comprising said dyes and to a write only read many (WORM) type optical recording medium capable of recording and reproducing information with radiation of a red laser, which employs said pentamethine cyanine azo complex type dye in the optical layer.

Abstract: A process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula (1) or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula (2) in the presence of at least 1, respectively at least 2 equivalents of a base, with Y?N—R as formula (1), wherein Y is selected from a substituted carbon, or nitrogen atom and R represents a substituent, and with Mv(L1)k(L2)l(L3)m(L4)nx as formula (2), wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L1, L2, L3, and L4 represent a ligand or a group 17 halogen atom on M and may be equal or different, X represents a group 17 halogen atom, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V.

Abstract: The invention relates to a process for the production of an organometallic compound according to formula (1): MALjYrX(p.