Abstract: The invention is directed to a method for determining a monomer sequence of a polymer that is translocated through a nanopore. Monomers of the polymer are labeled with fluorescent labels such that in free solution fluorescent labels of adjacent monomers substantially quench each other and wherein the nanopore constrains fluorescent labels within its bore into a constrained state wherein no detectable fluorescent signal can be generated. By exciting the fluorescent label of each monomer as it exits the nanopore and transitions from a constrained state to a quenched state with an adjacent fluorescent label, a fluorescent signal can be generated by the exiting fluorescent label that allows its monomer to be identified, thereby permitting a monomer sequence to be determined from a sequence of fluorescent signals as the polymer translocates through the nanopore.

Abstract: Various methods, systems and devices for optical detection and analysis of polymers, such as polynucleotides, using nanopores, e.g., for determining sequences of nucleic acids, are provided herein. In certain variations, methods and systems for determining a nucleotide sequence of a polynucleotide, which include measuring mixed FRET signals as a polynucleotide translocates through a nanopore and determining a nucleotide sequence of the polynucleotide from the mixed FRET signals, are provided.

Abstract: A shielded electrical cable includes at least two spaced-apart conductors extending side-by-side along a longitudinal cable direction. An insulation electrically insulates the conductors from each other. A cable shield, together with the conductors, extends along the longitudinal cable direction and annularly surrounds the conductors, as seen in cross section. An electrical device is disposed between the conductors and the cable shield. The electrical device is surrounded by the cable shield and disposed on the conductors such that the electrical device is in electrical contact with each of the conductors.

Abstract: A method and system for segmenting multiple brain structures in 3D magnetic resonance (MR) images is disclosed. After intensity standardization of a 3D MR image, a meta-structure including center positions of multiple brain structures is detected in the 3D MR image. The brain structures are then individually segmented using marginal space learning (MSL) constrained by the detected meta-structure.

Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.

Abstract: The present invention relates to the preparation of N-(2-(6-fluoro-1H-indol-3-yl)-ethyl)-3-(2,2,3,3-tetrafluoropropoxy)-benzylamine (Compound I), INN-name idalopirdine, and pharmaceutically acceptable salts thereof:

Abstract: A method and apparatus for hierarchical parsing and semantic navigation of a full or partial body computed tomography CT scan is disclosed. In particular, organs are segmented and anatomic landmarks are detected in a full or partial body CT volume. One or more predetermined slices of the CT volume are detected. A plurality of anatomic landmarks and organ centers are then detected in the CT volume using a discriminative anatomical network, each detected in a portion of the CT volume constrained by at least one of the detected slices. A plurality of organs, such as heart, liver, kidneys, spleen, bladder, and prostate, are detected in a sense of a bounding box and segmented in the CT volume, detection of each organ bounding box constrained by the detected organ centers and anatomic landmarks. Organ segmentation is via a database-guided segmentation method.

Abstract: The invention is directed to methods and apparatus for detecting sequences of optical signals from parallel reactions on an array of nanostructures, such as nanopores, nanowells, or nanoparticles. In accordance with the invention, an array of nanostructures is provided, each nanostructure comprising a reaction site and each capable of confining a reaction that generates a sequence of optical signals, and the nanostructures of the array being arranged in clusters each comprising a number of nanostructures. Each different cluster is disposed within a different resolution limited area and the number of nanostructures in each cluster is either greater than one or a random variable with an average value greater than zero. Optical signals from reactions in the nanostructures are detected by an optical system operatively associated with the array.

Abstract: Methods for fabricating materials useful for optical detection in microfluidic and nanofluidic devices, such as those used in nanopore-based nucleic acid sequencing are described herein. In certain variations, a method of reducing background fluorescence in a MEMS material may include the step of treating a surface of the MEMS material with a low energy ion beam.

Abstract: The invention is directed to methods and apparatus for detecting sequences of optical signals from parallel reactions on an array of nanostructures, such as nanopores, nanowells, or nanoparticles. In accordance with the invention, an array of nanostructures is provided, each nanostructure comprising a reaction site and each capable of confining a reaction that generates a sequence of optical signals, and the nanostructures of the array being arranged in clusters each comprising a number of nanostructures. Each different cluster is disposed within a different resolution limited area and the number of nanostructures in each cluster is either greater than one or a random variable with an average value greater than zero. Optical signals from reactions in the nanostructures are detected by an optical system operatively associated with the array.

Abstract: An electrical cable includes a cable jacket surrounding a cable interior. At least one electrical cable conductor is disposed in the cable interior and has an insulating sheath. A cable shield shields the cable interior. At least one electrically conductive drain wire associated with the cable shield is disposed in the cable interior in electrical contact with the cable shield. The at least one drain wire includes a ferromagnetic material.

Abstract: A method for the injection computation for an internal combustion engine, in particular for a gasoline range extender engine. This includes ascertaining an adaptation factor, which represents fuel aging, from a model of the fuel and a fuel outgassing via a tank vent and adaptation of a fuel injection quantity and/or a fuel injection time using the adaptation factor.

Abstract: A compound semiconductor device structure having a main surface and a rear surface includes a silicon substrate including first and second substrate layers. The first substrate layer extends to the rear surface. The second substrate layer extends to a first side of the substrate that is opposite from the rear surface such that the first substrate layer is completely separated from the first side by the second substrate layer. A nucleation region is formed on the first side of the silicon substrate and includes a nitride layer. A lattice transition layer is formed on the nucleation region and includes a type III-V semiconductor nitride. The lattice transition layer is configured to alleviate stress arising in the silicon substrate due to lattice mismatch between the silicon substrate and other layers in the compound semiconductor device structure. The second substrate layer is configured to suppress an inversion layer in the silicon substrate.

Abstract: A method and system for the diagnosis of 3D images are disclosed, which significantly cuts the time required for the diagnosis. The 3D images are for example an image volume dataset of a magnetic resonance tomography system which is saved in an RIS or PACS system. In at least one embodiment, the diagnostic finding are partially automatically generated, and details of the position, size and change in pathological structures are compared to previous diagnostic findings are generated automatically. As a result of this automation the diagnostic work of radiologists is significantly reduced.

Abstract: The invention relates to a method for the operation of at least one light emitting diode (5, 6) by means of a switching regulator circuit (20) preferably designed as a step-down converter, to which an input voltage (VDC) is supplied and which provides, by means of at least one switch (1) clocked by a control unit (10), an output voltage (VOUT) for the supply of the at least one light emitting diode (5, 6) with current that is regulated to be constant at least in the temporal average, wherein the setpoint for the LED current is adjustable for the dimming, wherein the regulation parameters for the regulation loop for the LED current are changed depending on the operating mode of the switching regulator circuit (20).

Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

Abstract: The invention relates to a machining device for the machine-assisted production and machining of dental workpieces (16), particularly of artificial teeth and/or other dental replacement parts, the at least one workpiece (16) being clamped in at least one work-piece retainer (11) which can be raised, lowered and rotatably driven, is positioned on a rotational axis (9), and, for the purpose of machining, feeds said workpiece (16) to at least one tool spindle (4, 5, 6) that is rotationally driven and has a tool (7) secured thereto, an additional tool retainer (2, 2a, 2b) with a plurality of tools (7) arranged thereupon being associated with said workpiece retainer (11, 11a, 11b) and lying opposite on one side thereof, and a workpiece changer (22, 22a, 22b) which receives the workpieces (16, 16a, 16b, 16c) to be machined, such that they can be exchanged, being arranged on the other side of said workpiece retainer (11, 11a, 11b).

Abstract: A document and template creation system includes a document and template creation device. The document and template creation device is configured to identify at least one domain ontology concept based on at least a portion of a text-string input into a document, propose the at least one domain ontology concept for selection by the user, and insert at least one of the at least one domain ontology concept into the document in response to selection by the user.

Abstract: The invention relates to a dosing system for an inhalation device which is capable of aliquoting a precise and accurately metered volume from a larger pre-defined fill volume. The dosing system comprises a filling chamber for receiving a liquid to be aerosolized, the filling chamber having a lateral wall, an inlet opening and an outlet opening with a closing means (11) for closing the outlet opening. The dosing system further comprises an overflow chamber surrounding the inlet opening of the filling chamber and a plunger which can be inserted, at least partially, into the filling chamber, and which sealingly contacts the lateral wall such as to displace liquid from said filling chamber upon insertion, and push a metered volume of the liquid out from the filling chamber through the outlet opening and feed it to the nebulizing means of the inhalation device.