Abstract: A firearm optic assembly has a body, the body having a first mounting facility configured to removably connect the body to the firearm, the body having a first receptacle configured to receive a first accessory, the body having a second mounting facility configured to removably receive a second mount portion associated with a second accessory offset from the medial plane, the second mounting facility including a pocket defined by one of the body and the second mount portion, the second mounting facility including a protrusion on the other of the body and the second mount portion, the protrusion being configured to be slidably or loosely received in the pocket, the protrusion having a free end and an opposed base end, the second mounting facility having an alignment facility including flared surfaces at the base end, and the flared surfaces being on opposing sides of the protrusion.

Abstract: An implant assembly for use in tissue repairs includes a fixation device and a flexible elongate implant. The fixation device has a body with a first surface adapted to face towards a bone and a second surface adapted to face away from the bone. Apertures extend through the fixation device body from the first surface to the second surface and serve to attach one end of the flexible elongate implant loop. The flexible elongate implant has a multifilament structure comprising filaments which are of a metallic or non-metallic material. The implant is coupled to the fixation device by passing through the apertures, and has a loop having a first end that is secured to the fixation device and a second end which can be releasably coupled to the fixation device following passage through or around a bone, for securing the implant assembly relative to the bone.

Abstract: An attachment (1) for a trocar cannula (3) having an access valve (12) located in a proximal end (5) thereof comprises a housing (20) defining an instrument passageway (29). An operating member (43) having an instrument bore (46) is slideable in the instrument passageway (29) from a disengaged state disengaged from the access valve (12) to an engagement state extending through the access valve (12) with the access valve (12) in the open state and shielded from an instrument passing therethrough. A pair of detecting probes (55) carried on a carrier (50) and extending into the instrument bore (46) are urgeable distally from a first state to a second state by a distal end of an instrument being urged distally in the instrument bore (46) for in turn urging the operating member (43) from the disengaged state to the engagement state.

Abstract: The invention provides a method for laser modification of a sample to form a modified region at a target location within the sample. The method comprises positioning a sample in a laser system for modification by a laser; measuring tilt of a surface of the sample through which the laser focusses; using at least the measured tilt to determine a correction to be applied to an active optical element of the laser system; applying the correction to the active optical element to modify wavefront properties of the laser to counteract an effect of coma on laser focus; and laser modifying the sample at the target location using the laser with the corrected wavefront properties to produce the modified region.

Abstract: A clip assembly (42) for securing a tubular member (5) to an endoscope (3) comprises a plurality of clips (40) tethered together by a looped tether (41). Each clip (40) comprises a first channel (48) for engaging the endoscope (3) and a second channel (50) for engaging the tubular member (5). Each clip comprises a carrier element (45) and an adapter element (47) secured to the carrier element (45). The carrier element (45) comprises a body member (52) having a pair of first side members (54) extending therefrom defining the first channel (48), and a pair of engagement side members (67) defining an engagement channel (69). The adapter element comprises an arcuate element (80) engaged in the engagement channel (69) for defining the second channel (50). A covering element (95) comprising a pair of end panels (91) extending from the arcuate element (80) cover ends (61) of the carrier element (45).

Abstract: A valve mechanism (3) for attaching to a proximal end (4) of a trocar cannula (2) for minimising leakage of insufflating and other gases proximally from the trocar cannula (2), comprises a housing (7) adapted for securing to the trocar cannula (2) adjacent the proximal end (4) thereof. The housing (7) defines an instrument bore (22) extending from a proximal end (23) to a distal end (21). A distal valve (28) is located adjacent the distal end (21) of the instrument bore (22) and is pivotal from an open state to a closed state. A proximal valve (40) is located towards the proximal end (23) of the instrument bore (22), and comprises first and second valve members (41) and (42) which are urgeable from a withdrawn state clear of the instrument bore (22) to an engagement state sealably engaging an instrument in the instrument bore (22) for sealing the instrument bore (22).

Abstract: Techniques for synthetic data generation in computer-based reasoning systems are discussed and include receiving a request for generation of synthetic data based on a set of training data cases. One or more focal training data cases are determined. For undetermined features (either all of them or those that are not subject to conditions), a value for the feature is determined based on the focal cases. In some embodiments, the generation of synthetic data may be conditioned on values of features, preserved features, such as unique identifiers, previous-in-time features, and using the other techniques discussed herein.

Abstract: Techniques for synthetic data generation in computer-based reasoning systems are discussed and include receiving a request for generation of synthetic data based on a set of training data cases. One or more focal training data cases are determined. For undetermined features (either all of them or those that are not subject to conditions), a value for the feature is determined based on the focal cases. In some embodiments, the generation of synthetic data may be conditioned on values of features, preserved features, such as unique identifiers, previous-in-time features, and using the other techniques discussed herein.

Abstract: An airfoil includes a root and a tip, which define a span of the airfoil therebetween. The airfoil also includes a leading edge and a trailing edge downstream of the leading edge along a flow direction. The leading edge and the trailing edge each extend across the span of the airfoil from the root to the tip. The airfoil further includes a pressure side surface and a suction side surface. The airfoil also includes a thermal barrier coating on the pressure side surface and the suction side surface. The thermal barrier coating includes a base layer and a top coat. A thickness of the base layer varies across each of the pressure side surface and the suction side surface with a maximum thickness of the base layer at the leading edge.

Abstract: A collection device (1) for minimising dispersal of pathogens into the environment during insufflating of the peritoneal cavity (12) of a subject (3), and which are entrained in insufflating gases and other gases escaping through an incision (8) in the abdominal wall (9) of the subject (3), through which a trocar is entered into the peritoneal cavity (12) comprises a patch (5) supported on a support framework (30). The patch (5) terminates in an outer peripheral portion (20) with a pressure sensitive adhesive (21) coated thereon for sealably securing the outer peripheral portion (20) to the abdominal wall (9). A central access opening (24) formed in the patch (5) tightly and sealably engages the trocar (10).

Abstract: A suturing device (1) for suturing parts (5,6) together of a lumen (8) with one or more sutures (3) comprises an actuator (34) having a handle (33) and first and second operating elements (60,68) slideable longitudinally on the handle (33). A tubular shield (35) extends from the handle (33), and a cannula (40) slideable in the tubular shield (35) is connected to the first operating element (60) for urging the cannula (40) between a withdrawn state within the tubular shield (35) to an extended state extending from the tubular shield (35). An elongated push rod (52) slideable in the cannula (40) terminating in a distal hook (55) is coupled to and operated by the second operating element (68). Anchor elements (22) of the suture (3) are located in the cannula (40), and are sequentially urged therefrom by the push rod (52), as the cannula (40) sequentially pierces through the parts (5,6).

Abstract: Techniques for synthetic data generation in computer-based reasoning systems are discussed and include receiving a request for generation of synthetic data based on a set of training data cases. One or more focal training data cases are determined. For undetermined features (either all of them or those that are not subject to conditions), a value for the feature is determined based on the focal cases. In some embodiments, the generation of synthetic data may be conditioned on values of features, preserved features, such as unique identifiers, previous-in-time features, and using the other techniques discussed herein.

Abstract: A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Abstract: A rotor blade is provided. The rotor blade includes a main body having a shank, an airfoil extends radially outwardly from the shank, and a platform. The main body includes a pressure side slash face and a suction side slash face. A slot is defined within each of the pressure side slash face and the suction side slash face. The slot of the pressure side slash face and the slot of the suction side slash face each include an upstream end portion that defines an end and a main body portion extending from the upstream end portion. The upstream end portion tapers from the end to the main body portion. The main body portion further includes a retention wall that covers a portion of the end and that defines an opening. The retention wall further includes an inner retention surface. The retention wall defines an offset from the opening.

Abstract: A hearing prosthesis, the hearing prosthesis including a plurality of sound capture devices and a determinator configured to generate a parameter indicative of an orientation of the plurality of sound capture devices relative to a reference, wherein the hearing prosthesis is configured to adjust a direction of focus of the hearing prosthesis based on at least the parameter.

Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.

Abstract: A system for a turbine blade tip to address wear during rubbing with a shroud, and also tip rail cooling, is provided. The turbine blade tip includes a tip rail and cooling passage(s) extending through a radially outer end surface thereof, providing direct cooling to the tip. The tip rail may include tip rail cooling inserts. The radial outer end surface of the tip rail includes a first portion radially inward of a second portion thereof. An abrasive layer extends along the first portion adjacent the cooling passage(s), and may include a matrix alloy having a plurality of cubic boron nitride (cBN) particles and a plurality of ceramic particles embedded therein. The abrasive layer extends radially outward of the second portion of the radial outer end surface. The system also may include a shroud including an abradable coating thereon.

Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g., Pseudomonas aeruginosa and Cryptococcus neoformans) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.