Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C?O)—, —(C?S)—, —SO.sub.

Abstract: A sleep assistance device is provided-for, including a contactless biometric sensor, a processor, memory, and a speaker. The processor detects a user's sleep state by reading signals from the contactless biometric sensor. The processor may then initiate a wind-down routine upon detecting a sleep-readiness state, including playing relaxing sounds or playing a respiration entrainment sound. The processor may also play noise-masking sounds upon detecting that a user has fallen asleep and seamlessly transition between the sounds played during the wind-down routine and the noise-masking sounds.

Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is —O—, —S—, —(C?O)—, —(C?S)—, —SO.sub.

Abstract: A cementitious binder comprises at least 90% by weight of a hydraulically-active material comprising ground granulated blast furnace slag (GGBS) and/or pulverised fuel ash (PFA), and at least 0.1% by weight of CaO in an activator composition for the hydraulically-active material. The cementitious binder does not comprise any Portland cement and is, therefore, more environmentally friendly. The binder further comprises a superplasticiser such as a polycarboxylate ether (PCE). A concrete, mortar, grout, screed or render may be formed from a mixture of the cementitious binder, aggregate particles, water and superplasticiser.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for access control for enterprise information. In one aspect, a method includes receiving resources of an enterprise, each resource having a respective access control list specifying access privileges to the resource for one or more members, and the resources including entities related to the enterprise and relationships; identifying entity facts of the entities from the resources; determining, for each entity fact, an entity fact access control list; storing data describing the entities, entity facts and the respective entity fact access control lists, wherein each entity fact is associated with its corresponding entity fact access control list; and providing, to each of the members of the enterprise, access privileges to the data describing the entities and the entity facts according to the respective entity fact access control lists.

Abstract: Various embodiments of the disclosure include an alignment apparatus for assembly alignment and load sharing. The alignment apparatus may include: an alignment pin including a first end and an opposing, second end, wherein the first end is configured to couple with a first hole in a first turbine nozzle diaphragm and the second end is configured to couple with a second hole in a second, adjacent turbine nozzle diaphragm. Embodiments of the disclosure may also include a turbine and a combined-cycle power plant. The turbine may include: a first nozzle diaphragm; and a second, adjacent nozzle diaphragm, wherein the first diaphragm is directly coupled to the second diaphragm. The combined-cycle power plant may include: a steam turbine; a gas turbine; a first nozzle diaphragm within the gas turbine; a second, adjacent nozzle diaphragm within the gas turbine; and an alignment pin coupling the first diaphragm directly to the second diaphragm.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for access control for enterprise information. In one aspect, a method includes receiving resources of an enterprise, each resource having a respective access control list specifying access privileges to the resource for one or more members, and the resources including entities related to the enterprise and relationships; identifying entity facts of the entities from the resources; determining, for each entity fact, an entity fact access control list; storing data describing the entities, entity facts and the respective entity fact access control lists, wherein each entity fact is associated with its corresponding entity fact access control list; and providing, to each of the members of the enterprise, access privileges to the data describing the entities and the entity facts according to the respective entity fact access control lists.

Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.

Abstract: The present invention relates to genetically modified microorganisms comprising one or more heterologous nucleic acid molecules together encoding at least three different proteins, each protein comprising an enzymatic domain and a bacterial microcompartment-targeting signal polypeptide, wherein said enzymatic domains each catalyse a different substrate to product conversion in the same metabolic pathway, and wherein said microorganisms are essentially free of bacterial microcompartments (BMCs); and to cell free systems comprising aggregates comprising at least three different proteins, each protein comprising an enzymatic domain and a bacterial microcompartment-targeting signal polypeptide, wherein said enzymatic domains each catalyse a different substrate to product conversion in the same metabolic pathway, and wherein said system does not comprise bacterial microcompartments; and to methods for the production of said microorganisms and cell free systems and their use in methods of producing a product of int

Abstract: The described embodiments relate to systems, methods, and apparatuses for establishing a network of sensor-responsive lighting units using an interface of each lighting unit. The interface of each lighting unit can include a channel selector switch for selecting a channel to which each lighting unit will be connected. In this way, the creation of a network can be created by placing the lighting units proximate to each other and selecting the same channel at the interface at each lighting unit. The lighting units can include sensors for detecting events occurring at each lighting unit, and information related to the detected events can be shared among other lighting units in the network. Each lighting unit can operate in different operating modes such as a testing mode for testing communications channels and a manual mode for allowing a lighting unit to operate independently of the information shared over the network.

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A kit includes a pair of items of footwear; wherein each item of footwear includes a brace that is arranged to be releasably secured to at least part of a wearer's leg and/or foot; a platform that is operably connected to the brace; and a securing mechanism for releasably securing a balancing member, or a stack of balancing members, underneath the platform. The kit includes balancing members for each item of footwear so that one balancing member can be replaced with another balancing member that has a smaller ground-contacting area, or so that it can have another balancing member with a smaller ground-contacting area stacked underneath it.

Abstract: Systems and methods of managing research agreements between members in an open-science community are disclosed. A method includes recording a proposal from a researcher in a decentralized ledger, storing funds from a funder in the decentralized ledger, generating a first notification in the decentralized ledger that distributes an indicator to the researcher and the funder that a first portion of the research is to commence, recording deliverables from the researcher to the decentralized ledger, recording votes that indicate whether the deliverables comply with rules established from the proposal in the decentralized ledger, and when a majority of the votes indicates that the deliverables complies with the rules, distributing a tranche of the funds to the researcher and recording the distribution in the decentralized ledger and generating a second notification that distributes an indicator to the researcher and the funder that a second portion of the research is to commence.

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A hearing prosthesis, the hearing prosthesis including a plurality of sound capture devices and a determinator configured to generate a parameter indicative of an orientation of the plurality of sound capture devices relative to a reference, wherein the hearing prosthesis is configured to adjust a direction of focus of the hearing prosthesis based on at least the parameter.