Abstract: A firearm optic assembly has a body, the body having a first mounting facility configured to removably connect the body to the firearm, the body having a first receptacle configured to receive a first accessory, the body having a second mounting facility configured to removably receive a second mount portion associated with a second accessory offset from the medial plane, the second mounting facility including a pocket defined by one of the body and the second mount portion, the second mounting facility including a protrusion on the other of the body and the second mount portion, the protrusion being configured to be slidably or loosely received in the pocket, the protrusion having a free end and an opposed base end, the second mounting facility having an alignment facility including flared surfaces at the base end, and the flared surfaces being on opposing sides of the protrusion.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C?O)—, —(C?S)—, —SO.sub.

Abstract: The rotor blade includes a platform and a shank extending radially inward from the platform. The rotor blade further includes an airfoil extending radially outward from the platform. The airfoil includes a leading edge and a trailing edge. A cooling circuit is defined within the shank and the airfoil. The cooling circuit includes a plurality of pins. The plurality of pins includes a first pin group positioned radially inward of the platform and a second pin group positioned within the airfoil. The cooling circuit further includes a plurality of exit channels disposed along the trailing edge. The plurality of exit channels is downstream from the plurality of pins. The cooling circuit also includes at least one bypass conduit extending from an inlet disposed in the cooling circuit to an outlet positioned on the trailing platform face. The at least one bypass conduit is positioned radially inward of the platform surface.

Abstract: The rotor blade includes a platform and a shank extending radially inward from the platform. The rotor blade further includes an airfoil extending radially outward from the platform. The airfoil includes a leading edge and a trailing edge. A cooling circuit is defined within the shank and the airfoil. The cooling circuit includes a plurality of pins. The plurality of pins includes a first pin group positioned radially inward of the platform and a second pin group positioned within the airfoil. The cooling circuit further includes a plurality of exit channels disposed along the trailing edge. The plurality of exit channels is downstream from the plurality of pins. The cooling circuit also includes at least one bypass conduit extending from an inlet disposed in the cooling circuit to an outlet positioned on the trailing platform face. The at least one bypass conduit is positioned radially inward of the platform surface.

Abstract: Rotor blades and turbomachines are provided. The rotor blade includes a main body having a shank, an airfoil extending radially outwardly from the shank, and a platform. The main body further includes a pressure-side slash face and a suction-side slash face. Each of the pressure-side slash face and the suction-side slash face includes a damper land and defines a slot. The damper land is disposed radially inward from the slot.

Abstract: An airfoil includes a root and a tip, which define a span of the airfoil therebetween. The airfoil also includes a leading edge and a trailing edge downstream of the leading edge along a flow direction. The leading edge and the trailing edge each extend across the span of the airfoil from the root to the tip. The airfoil further includes a pressure side surface and a suction side surface. The airfoil also includes a thermal barrier coating on the pressure side surface and the suction side surface. The thermal barrier coating includes a base layer and a top coat. A thickness of the base layer varies across each of the pressure side surface and the suction side surface with a maximum thickness of the base layer at the leading edge.

Abstract: The present application provides a turbine rotor blade including an airfoil shape and a trailing edge shape. The airfoil shape may have a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in Table I, while the trailing edge profile is defined by Table II. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a height of the airfoil in the unit of distance (e.g., inches). The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The airfoil profile sections at Z distances may be joined smoothly with one another to form a complete airfoil shape.

Abstract: The present application provides a turbine rotor blade including an airfoil shape and a trailing edge shape. The airfoil shape may have a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in Table I, while the trailing edge profile is defined by Table II. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a height of the airfoil in the unit of distance (e.g., inches). The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The airfoil profile sections at Z distances may be joined smoothly with one another to form a complete airfoil shape.

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: The described embodiments relate to systems, methods, and apparatuses for establishing a network of sensor-responsive lighting units using an interface of each lighting unit. The interface of each lighting unit can include a channel selector switch for selecting a channel to which each lighting unit will be connected. In this way, the creation of a network can be created by placing the lighting units proximate to each other and selecting the same channel at the interface at each lighting unit. The lighting units can include sensors for detecting events occurring at each lighting unit, and information related to the detected events can be shared among other lighting units in the network. Each lighting unit can operate in different operating modes such as a testing mode for testing communications channels and a manual mode for allowing a lighting unit to operate independently of the information shared over the network.

Abstract: A rotor blade is provided. The rotor blade includes a main body having a shank, an airfoil extends radially outwardly from the shank, and a platform. The main body includes a pressure side slash face and a suction side slash face. A slot is defined within each of the pressure side slash face and the suction side slash face. The slot of the pressure side slash face and the slot of the suction side slash face each include an upstream end portion that defines an end and a main body portion extending from the upstream end portion. The upstream end portion tapers from the end to the main body portion. The main body portion further includes a retention wall that covers a portion of the end and that defines an opening. The retention wall further includes an inner retention surface. The retention wall defines an offset from the opening.

Abstract: A cloud-based system for monitoring food storage/processing comprising at least one fixed sensor to collect fixed location environment data; at least one handheld sensor to collect mobile location environment data; and a remote monitoring and reporting system to collect the fixed and remote location environment data and to audit the collected data. A portable device comprises a processor configured to: receive the mobile location environment data; and transmit an auditable version of the received mobile location environment data to the remote system. A hub device comprising a processor configured to: receive the fixed location environment data; and transmit an auditable version of the fixed location environment data. The monitoring and reporting system is configured to determine whether the version of the environment data indicates that the monitored environment is operating within the bounds of a model defining correct operation of a food process and to output an alert if necessary.

Abstract: A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: The present invention relates to a method for providing three-dimensional ultrasound images of a volume (50) and an ultrasound imaging system (10). In particular, the current invention applies to live three-dimensional imaging. To maintain a steady frame rate of the displayed images even if a user changes a region of interest and, therewith, the size of the volume (50) to be scanned, it is contemplated to adjust a density of the scanning lines within the volume (50) as a function of a size of the volume while maintaining a total number of scanning lines across the volume (50).

Abstract: The present invention relates to genetically modified microorganisms comprising one or more heterologous nucleic acid molecules together encoding at least three different proteins, each protein comprising an enzymatic domain and a bacterial microcompartment-targeting signal polypeptide, wherein said enzymatic domains each catalyse a different substrate to product conversion in the same metabolic pathway, and wherein said microorganisms are essentially free of bacterial microcompartments (BMCs); and to cell free systems comprising aggregates comprising at least three different proteins, each protein comprising an enzymatic domain and a bacterial microcompartment-targeting signal polypeptide, wherein said enzymatic domains each catalyse a different substrate to product conversion in the same metabolic pathway, and wherein said system does not comprise bacterial microcompartments; and to methods for the production of said microorganisms and cell free systems and their use in methods of producing a product of int

Abstract: There is provided a method of fabricating a trapped vacancy in a crystal lattice of a target comprising: positioning the target in a laser system, the target containing vacancy trapping elements within the crystal lattice; modifying the crystal lattice within the target by using a laser to generate a lattice vacancy; and annealing the target to cause the lattice vacancy to migrate and be captured by a vacancy trapping element to form the trapped vacancy in the crystal lattice.

Abstract: Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g., Pseudomonas aeruginosa and Cryptococcus neoformans) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.

Abstract: Disclosed herein is an expandable device adapted to forcibly separate spaced components having generally parallel opposed surfaces defining a cavity therebetween, the expandable device having a jaw assembly with a pair of opposing jaws and actuating means for opening the jaws, the actuating means including a separating member configured to be driven between the jaws so as to push apart the jaws such that the jaws are openable between a contracted configuration where the jaws are receivable in the cavity to an expanded configuration where the jaws are forced apart by the actuating means such that the outwardly directed surfaces of the jaws are engageable with the opposed surfaces and exert oppositely directed forces thereon. Also disclosed herein is an apparatus configured to carry at least one said expandable device, and an assembly comprising two said apparatus.