Abstract: The present disclosure relates to a system, method, and apparatus that incentivizes users to give thoughtful answers when completing reviews by only rewarding, a portion of users that complete the reviews. An item (e.g., an advertisement, product design, or logo) may be presented to a number of users along with a query about the item. Answers may be received from the users and a comparison value may be calculated for the answers. A deviation value may then be determined for each user between the answer the user provided and the comparison value. The number of users may then be ranked according to their respective deviation values with a lower deviation value corresponding to a lower ranking. One or more users with the lowest rankings may then be provided with a reward.

Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

Abstract: The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2?-substituted nucleotides, such as 2?-O-methyl or 2?-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

Abstract: A portable jig and fixture having at least one base plate, a column assembly removably coupled to the at least one base plate, a slide assembly removably coupled to the column assembly, a power feed head removably coupled to the slide assembly, and a spindle unit removably coupled with the slide assembly having a motor removably engaged it. At least one cutter assembly is removably engaged with the spindle unit and at least one drill jig is also removably engaged with the spindle unit. Also, a turbomachine having complementary structure on the compressor discharge casing can engage with the at least one base plate alignment mounting structure on the portable jig and fixture.

Abstract: The present invention features compounds having BTK inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.

Abstract: Systems, methods, and computer-readable media for coordinating processing of data by multiple networked computing resources include monitoring data associated with a plurality of networked computing resources, and coordinating the routing of data processing segments to the networked computing resources.

Abstract: An embodiment is directed to a Li metal or Li-ion battery, including a conversion-type metal fluoride comprising cathode capable of storing and releasing Li ions during battery operation, a conversion-type type or Li metal-type anode capable of storing and releasing Li ions during battery operation, a separator membrane ionically coupling and electronically insulating the cathode and the anode, and a solid electrolyte with a Li transference number in the range from around 0.7 to around 1.0 impregnating at least the cathode, wherein the cathode comprises composite a core-shell particle and has an areal capacity loading that ranges from around 2 mAh/cm2 to around 12 mAh/cm2.

Abstract: An apparatus for cleaning an inner surface of a slot includes a first block segment that has an outer perimeter that conforms to and fits inside the inner surface of the slot. A first cleaning pad is connected to the first block segment and extends beyond at least a portion of the outer perimeter of the first block segment.

Abstract: Disclosed is a three phase Vienna converter for converting three phase AC to DC, with active power factor control. Further the control electronics is galvanically isolated from the neutral of the input three phase supply and also from the center terminal of the two series connected output DC filter capacitors. The control circuit is built completely with analog devices to meet stringent electromagnetic interference standards. The converter is capable of operating over a wide range of voltages and frequencies of the input supply voltage.

Abstract: Disclosed is a garment comprising a hooded-coat and overalls designed for improved durability and comfort. The garment is waterproof throughout. The coat has an outer layer of Kevlar fabric in the abdominal region, the outer edges of the sleeves, and along the hem. The overalls have an outer layer of Kevlar fabric on the front of the legs and on the seat. The hood and coat sections each have light reflective stripes for greater visibility and safety. There are also built in knee pads, pockets, and openings for comfort, storage, and ventilation. The garment is particularly well suited for outdoor workers exposed to weather extremes and hard, abrasive contact with the environment.

Abstract: The present disclosure relates to a system, method, and apparatus that incentivizes users to give thoughtful answers when completing reviews by only rewarding a portion of users that complete the reviews. An item (e.g., an advertisement, product design, or logo) may be presented to a number of users along with a query about the item. Answers may be received from the users and a comparison value may be calculated for the answers. A deviation value may then be determined for each user between the answer the user provided and the comparison value. The number of users may then be ranked according to their respective deviation values with a lower deviation value corresponding to a lower ranking. One or more users with the lowest rankings may then be provided with a reward.

Abstract: Systems, methods, and computer-readable media for coordinating processing of data by multiple networked computing resources include monitoring data associated with a plurality of networked computing resources, and coordinating the routing of data processing segments to the networked computing resources.

Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

Abstract: A ring laser gyroscope comprises a laser block that includes a resonant internal cavity defined by a plurality of surfaces of an optical closed loop pathway, and a plurality of electrodes coupled to the laser block. The electrodes are configured to generate a pair of counter-propagating laser beams from a lasing gas in the optical closed loop pathway. The ring laser gyroscope also includes a field reducer shield comprising an electrically conductive material, with the field reducer shield located completely within the laser block. The field reducer shield is configured to modify an electric field generated by the plurality of electrodes to substantially prevent ions in the laser block from migrating toward the plurality of surfaces of the optical closed loop pathway.

Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

Abstract: A fixture for restraining a wheel of a turbomachine is provided. The fixture includes a dovetail section adapted for insertion into a dovetail slot of the wheel, and a mounting section located adjacent to, or formed integrally with, the dovetail section. At least one coupling ring is attached to a top of the mounting section. The at least one coupling ring is adapted to be secured to a stationary anchoring point via a restraint.

Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

Abstract: A ring laser gyroscope comprises a laser block that includes a resonant internal cavity defined by a plurality of surfaces of an optical closed loop pathway, and a plurality of electrodes coupled to the laser block. The electrodes are configured to generate a pair of counter-propagating laser beams from a lasing gas in the optical closed loop pathway. The ring laser gyroscope also includes a field reducer shield comprising an electrically conductive material, with the field reducer shield located completely within the laser block. The field reducer shield is configured to modify an electric field generated by the plurality of electrodes to substantially prevent ions in the laser block from migrating toward the plurality of surfaces of the optical closed loop pathway.

Abstract: A fixture for restraining a wheel of a turbomachine has a dovetail section adapted for insertion into a dovetail slot of the wheel. A mounting section is located adjacent to, or formed integrally with, the dovetail section. At least one coupling ring is attached to the mounting section, and the coupling ring is adapted to be secured to a stationary anchoring point via a restraint. The stationary anchoring point includes at least one counterbore assembly having a coupling ring attached thereto. The counterbore assembly is adapted to be secured to a stationary structure. The stationary structure may be a shell, a flange or a casing of the turbomachine.

Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.