Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

Abstract: A turbomachine rotor blade milling machine system includes a fixture having a body including first and second opposing surfaces and a slot. The fixture is configured and disposed to connect with first and second rotor blade sections mounted in a rotor wheel. A mounting system includes at least one mounting element coupled to one of the first and second opposing surfaces of the body at the slot. A milling machine is coupled to the one of the first and second opposing surfaces through the at least one mounting element. The milling machine includes a cutter and is configured and disposed to form an opening extending axially through a dovetail portion of a third rotor blade section arranged between the first and second rotor blade sections.

Abstract: A fixture for restraining a wheel of a turbomachine has a dovetail section adapted for insertion into a dovetail slot of the wheel. A mounting section is located adjacent to, or formed integrally with, the dovetail section. At least one coupling ring is attached to the mounting section, and the coupling ring is adapted to be secured to a stationary anchoring point via a restraint. The stationary anchoring point includes at least one counterbore assembly having a coupling ring attached thereto. The counterbore assembly is adapted to be secured to a stationary structure. The stationary structure may be a shell, a flange or a casing of the turbomachine.

Abstract: A fixture for restraining a wheel of a turbomachine is provided. The fixture includes a dovetail section adapted for insertion into a dovetail slot of the wheel, and a mounting section located adjacent to, or formed integrally with, the dovetail section. At least one coupling ring is attached to a top of the mounting section. The at least one coupling ring is adapted to be secured to a stationary anchoring point via a restraint.

Abstract: The present invention relates to methods for producing encoded chemical entities. In particular, the oligonucleotides and methods can include encoded chemical entities having wild-type linkages formed through chemical ligation techniques. One strategy that can be utilized that simultaneously takes advantage of chemical ligation as a means to encode chemical history, while also retaining the ability of polymerases to directly recover tag sequence and association information, is to perform chemical ligation in a manner that generates wildtype phosphodiester linkages. Such methods generally utilize condensing agents such as cyanogen bromide or similar along with 5?-phosphate and 3?-hydroxyl oligonucleotides in a double-stranded or templated context. Similarly cyanogen bromide has also been shown to chemically ligate pairs of substrate oligonucleotides that are 5?-hydroxyl and 3?-phosphate.

Abstract: The present invention is directed to a system for monitoring a physiological parameter of a cyclist, and methods of using the system. The system comprises a garment, a sensor, and a signal processor. The garment is configured to be worn by the cyclist. The sensor is fixedly coupled to the garment and configured to measure a signal representative of the physiological parameter during pedaling. The signal processor is operatively coupled to the sensor and configured to determine a diagnosis based on the measured signal. An alert is generated in response to the diagnosis substantially in real time.

Abstract: A system for repairing dovetail slots includes a slot adaptor having a body configured and disposed to nest between first and second side walls of a dovetail slot, and a tool holder configured to be coupled with the slot adaptor. The tool holder includes a tool guidance system configured and disposed to direct a tool into contact with one of the first and second side walls of the dovetail slot. A cutting tool is mounted in the tool holder. The cutting tool includes a tapered surface configured and disposed to form a tapered recess in the one of the first and second side walls of the dovetail slot.

Abstract: Embodiments of the present disclosure relate generally to an apparatus and method for treating a rotatable component. An apparatus according to the present disclosure can include: a sliding engagement member configured to slidably engage a portion of a rotating component that is temporarily stationary; and a tool engaging member for positioning a machining tool relative to the rotating component to machine a surface of the rotating component, wherein the tool engaging member is rotatable to one of a plurality of angles relative to the sliding engagement member.

Abstract: A system and method of determining an output of an n-input fuzzy logic system are provided. A plurality of membership functions associated with a corresponding plurality of inputs is determined along with a list of fuzzy rules for the n-input fuzzy logic system. An input of the plurality of inputs is selected. Two active rules and their corresponding output values are selected from the list of rules. Membership values of two active membership functions are determined. An output of the n-input fuzzy system is calculated by multiplying the two membership values with the output of the two active rules and is saved. Recursively repeating, for each additional input, the determining and calculating steps and multiplying the output with the saved output, then saving the new output.

Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

Abstract: A partially-insulated cathode for exciting plasma in a plasma chamber is provided. The partially-insulated cathode includes a conductive structure enclosing a cavity having a cavity surface and an insulating material contiguously covering a portion of the cavity surface from the cavity opening up to an insulation height that is less than a cavity height. Cross-sections of the cavity in X-Y planes have at least one respective cavity-width. A cavity opening has a diameter less than a minimum cavity-width of the at least one cavity-width.

Abstract: A partially-insulated cathode for exciting plasma in a plasma chamber is provided. The partially-insulated cathode includes a conductive structure enclosing a cavity having a cavity surface and an insulating material contiguously covering a portion of the cavity surface from the cavity opening up to an insulation height that is less than a cavity height. Cross-sections of the cavity in X-Y planes have at least one respective cavity-width. A cavity opening has a diameter less than a minimum cavity-width of the at least one cavity-width.

Abstract: A system for repairing dovetail slots includes a slot adaptor having a body configured and disposed to nest between first and second side walls of a dovetail slot, and a tool holder configured to be coupled with the slot adaptor. The tool holder includes a tool guidance system configured and disposed to direct a tool into contact with one of the first and second side walls of the dovetail slot. A cutting tool is mounted in the tool holder. The cutting tool includes a tapered surface configured and disposed to form a tapered recess in the one of the first and second side walls of the dovetail slot.

Abstract: A CaQL API is provided by receiving a query directed to a catalog that includes metadata. A catalog access target is determined based at least in part on one or more of the following: a CaQL keyword which is included in the query, a name of a table in the catalog which is included in the query, or a predicate which is included in the query. A catalog function is generated based at least in part on the CaQL keyword and the catalog function is performed on the catalog access target.

Abstract: An apparatus for cleaning an inner surface of a slot includes a first block segment that has an outer perimeter that conforms to and fits inside the inner surface of the slot. A first cleaning pad is connected to the first block segment and extends beyond at least a portion of the outer perimeter of the first block segment.

Abstract: The present invention features benzhydrol-pyrazole derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.

Abstract: The present invention features tryptoline derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.

Abstract: An online advertising system stores advertisement placements and an advertisement campaign that is associated with the advertisement placements. The advertisement campaign includes a plurality of advertisement sets that each are associated with a respective set of selection rules. A request for an advertisement is received from a publishing system, the request specifying an advertisement placement and including advertisement selection information. The advertisement campaign is identified based in part on the advertisement placement, and an advertisement set is selected based in part on the selection information and a set of selection rules associated with the advertisement set. A creative group within the selected advertisement set is selected based on the selection rules, and an advertisement within the selected created group is selected using portions of the advertisement selection information and asset parameters associated with the advertisements in the selected creative group.