Abstract: A vehicle transaxle comprising a plurality of mounting flanges fixedly mountable to an axle tube of the vehicle absent any additional structure for mounting the transaxle to the vehicle. The axle tube houses a wheel axle to which the transaxle is operably couplable. The transaxle additionally comprises a transaxle mounting collar that is fixedly mounted to or integrally formed with a housing of the transaxle. The mounting collar is structured and operable to have a prime mover of the vehicle mounted thereto and to support the weight/mass of the prime mover such that the prime mover is mountable to the vehicle via only the mounting collar absent any additional structure for mounting the prime mover to the vehicle such that the prime mover can be cantilevered from (e.g., suspended from) the transaxle, e.g., the prime mover is ‘free floating’.

Abstract: A device for perforating a perforating gun body, while leaving adjacent tubulars unperforated, adapted for situations where it may be desirable to use a perforating gun with a loaded number of shaped charges that is less than its full capacity.

Abstract: Wearable articles, such as adhesive tapes, for prevention of tick and other pest bites includes flexible substrates having first and second opposite sides. The first side includes an adhesive configured to adhere the article to a user's skin, while the second side includes an attractant site configured to attract the pest, and a trap site configured to trap the pest. Methods for making an adhesive tape for the prevention of tick bites include providing such a substrate, placing a skin adhesive on one surface, and placing a chemoattractant and tick or insect adhesive on the second surface.

Abstract: A link jet system using a combination of a one piece cast zinc alloy case and interlocking linked shaped charges for minimizing debris left in a downhole wellbore when fired, reducing components in system, and providing an easy method for changing the shaped charge phase.

Abstract: A method and apparatus for containing one or more shaped charges in a single plane, arrayed about the center axis of a gun body, and detonated from a single initiator in a shaped charge cluster assembly.

Abstract: A link jet system using a combination of a one piece cast zinc alloy case and interlocking linked shaped charges for minimizing debris left in a downhole wellbore when fired, reducing components in system, and providing an easy method for changing the shaped charge phase.

Abstract: Compositions and methods are provided for treating hemangiosarcoma in a subject. A recombinant AAV comprising a capsid and a vector genome comprising a nucleic acid expression cassette is provided. The expression cassette includes sequences encoding a promoter, a first signal peptide operably linked to an anti-VEGF antibody heavy chain immunoglobulin, a linker sequence, and a second signal peptide operably linked to an anti-VEGF light chain immunoglobulin, wherein said expression cassette co-expresses the immunoglobulin chains in a host cell under conditions which permit the chains to assemble into a functional anti-VEGF antibody. In one embodiment, the anti-VEGF antibody is a chimeric antibody.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: A harness (10) is provided for securing a pair of electrical insulating sleeves (12) to a user (16) and includes a pair of shoulder straps (18), each shoulder strap (18) having a middle portion (20) extending between opposite end portions (22,24), and each middle portion (20) including an array of fastener receiving openings (26). Each fastener receiving opening (26) is configured to receive a fastener (28) for attaching an insulating sleeve (12). An adjustable chest strap (32) is engaged with each of the opposite end portions (22,24) of the shoulder straps (18) and is configured to extend around the torso (14) of a user (16) to secure the harness (10) to a user (16). A shoulder adjustment strap (50) extends between the shoulder straps (18) to be located behind the neck of a user (16) when the harness (10) is worn by a user (16) and is configured to provide adjustment of the middle portions (20) relative to each other.

Abstract: A shotgun stick for use with grounding devices is provided. An example shotgun stick includes a housing and a drive shaft supported within the housing. The shotgun stick further includes a torque connector coupled with a first end of the drive shaft that receives a grounding clamp assembly. The shotgun stick includes a motor assembly operably connected to a second end of the drive shaft. In an automatic mode, the motor assembly drives the drive shaft so as to actuate the grounding clamp assembly received by the torque connector. The shotgun stick also includes a manual locking mechanism. In a manual mode, the manual locking assembly locks the drive shaft to at least a portion of the housing so as to preclude rotation of the drive shaft and allow manual actuation of the grounding clamp assembly received by the torque connector.

Abstract: Methods and systems are provided for robotic assisted surgery. A robotic system includes a localizer, a surgical robotic manipulator, an end effector configured to be removably coupled to the manipulator, and a controller. The controller is configured to receive signals from the localizer, determine a final position of a cavity creation tool used to penetrate a portion of a patient's anatomy based on the signals received from the localizer, and determine an implant insertion path for an implant to be inserted into a final implant position within the portion of the patient's anatomy, wherein the final implant position corresponds to the final position of the cavity creation tool. The controller is also configured to move the end effector with the implant coupled thereto such that the implant moves along the implant insertion path, and terminate the movement of the end effector when the implant reaches the final implant position.

Abstract: A control valve includes a valve body having a main valve passageway. A flow control assembly is positioned in the main valve passageway and includes a first control element, and a second control element rotatable relative to the first control element between a closed position, a first position, and a second position. In the closed position, the first and second control elements form a plug which prevents fluid flow through the main valve passageway. In the first position, the first and second control elements collectively define a first control passageway therethrough, and in the second position, the first and second control elements collectively define the first control passageway and a second control passageway therethrough.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: Compositions and methods are provided for treating companion animals are provided. An adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding erythropoietin (EPO). In desired embodiments, the subject is a cat or dog.

Abstract: Compositions and methods for treating type II diabetes in a subject. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a propeptide and the active portion of GLP-1, wherein, when expressed, the N-terminal amino acid of GLP-1 immediately follows the C-terminal amino acid of the propeptide. In desired embodiments, the subject is a cat or dog.

Abstract: Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: An apparatus and method for connecting a shaped charge retainer to a shaped charge and connecting that to a charged tube in a perforating gun for use downhole.

Abstract: Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R1o is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: An apparatus and method for connecting a detonating cord with a shaped charge.