Abstract: The present invention relates to novel methods of treating Hepatitis B Virus by administering a KDM5 inhibitor.

Abstract: An objective assessment method for a stereoscopic image quality combined with manifold characteristics and binocular characteristics trains a matrix after dimensionality reduction and whitening obtained from natural scene plane images through an orthogonal locality preserving projection algorithm, for obtaining a best mapping matrix. Image blocks, not important for visual perception, are removed. After finishing selecting the image blocks, through the best mapping matrix, manifold characteristic vectors of the image blocks are extracted, and a structural distortion of a distorted image is measured according to a manifold characteristic similarity. Considering influences of an image luminance variation on human eyes, a luminance distortion of the distorted image is calculated according to a mean value of the image blocks.

Abstract: Structures and formation methods of a chip package are provided. The chip package includes a first package structure including a first semiconductor die that has a first side and a second side opposite thereto. The chip package also includes a package layer partially or completely encapsulating the first semiconductor die, and a conductive feature in the package layer. The chip package further includes a first heat-spreading layer over the first side of the first semiconductor die and a first cap layer on the first heat-spreading layer.

Abstract: Structures and formation methods of a chip package are provided. The chip package includes a first package structure including a first semiconductor die that has a first side and a second side opposite thereto. The chip package also includes a package layer partially or completely encapsulating the first semiconductor die, and a conductive feature in the package layer. The chip package further includes a first heat-spreading layer over the first side of the first semiconductor die and a first cap layer on the first heat-spreading layer.

Abstract: A method for evaluating quality of tone-mapping image based on exposure analysis is provided, which explores the exposure properties on each area of the high dynamic range image utilizing the pre-exposure method and divides the high dynamic range image into three parts of an easy overexposed area, an easy underexposed area and an easy natural-exposed area, wherein different quality characteristics are extracted in different areas, which is capable of ensuring that the follow-up quality characteristic extraction is more targeted. The present invention takes the difference of distortion between the tone-mapping image and the conventional image into account, and extracts image characteristics such as the abnormal exposure rate, the underexposed residual energy, the overexposed residual energy and the exposure color index, so as to accurately reflect the quality degradation of the tone-mapping image.

Abstract: A rapid autofocus method for a stereo microscope includes steps of: calculating a disparity of each of stereo microscopic images in a stereo microscopic calibration image sequence; extracting a clear stereo microscopic image sequence from the stereo microscopic calibration image sequence; then, finding out a largest disparity and a smallest disparity among the disparities of all the stereo microscopic images in the clear stereo microscopic image sequence; at a chosen magnification, arbitrarily acquiring a stereo microscopic image; finally, determining a disparity range according to the disparity of the acquired stereo microscopic image, the largest disparity and the smallest disparity, and realizing an autofocus of a target object in the acquired stereo microscopic images. The disparity range is obtained via once off-line calibration at the same magnification, and applicable to the autofocus at an arbitrary timing.

Abstract: A method for assessing an objective quality of a stereoscopic video based on reduced time-domain weighting, which considers a time domain perception redundant characteristic of human eyes during a video perception, includes steps of: through a motion intensity mean value and a motion intensity variance of an undistorted stereoscopic video and the motion intensity mean value and the motion intensity variance of each frame group, determining a motion intensity level of each frame group of the undistorted stereoscopic video; for the frame groups having different motion intensity levels, selecting undistorted reduced stereoscopic images through different frame extracting strategies with different densities; measuring a quality of a simultaneous distorted reduced stereoscopic image relative to the undistorted reduced stereoscopic image; through weighting each quality of the simultaneous distorted reduced stereoscopic image relative to the undistorted reduced stereoscopic image, obtaining a quality of a distorted s

Abstract: A video quality objective assessment method based on a spatiotemporal domain structure firstly combines a spatiotemporal domain gradient magnitude and color information for calculating a spatiotemporal domain local similarity, and then uses variance fusion for spatial domain fusion. The spatiotemporal domain local similarity is fused into frame-level objective quality value, and then a temporal domain fusion model is established by simulating three important global temporal effects, which are a smoothing effect, an asymmetric track effects and a recency effect, of a human visual system. Finally, the objective quality values of the distorted video sequence are obtained. By modeling the human visual temporal domain effect, the temporal domain weighting method of the present invention is able to accurately and efficiently evaluate the objective quality of the distorted video.

Abstract: An image quality objective evaluation method based on manifold feature similarity is disclosed, which firstly adopts visual salience and visual threshold to remove image blocks which are unimportant to visual perception, namely, uses roughing selection and fine selection; and then utilizes the best mapping matrix after block selection to extract manifold feature vectors of image blocks which are selected from original undistorted natural scene images and distorted images to be evaluated; and then measures the structural distortion of distorted images according to manifold feature similarity; and then considers effects of image brightness changes on human eyes and obtains the brightness distortion of distorted images based on an average value of image blocks, and finally obtains quality scores according to structural distortion and brightness distortion; which allows the method of the present invention to have a higher evaluation accuracy, and also expands the evaluation capacity to various distortions.

Abstract: The present invention is directed to a method for evaluating cosmetic materials for their efficacy in counteracting the effects of chronic stress on skin using a stress-induced premature senescence phenotype skin model. The present invention is also concerned with compositions containing a combination of actives for blocking or reversing the biological impact of chronic stress on the skin together with actives for rebuilding epidermis so as to restore elasticity.

Abstract: A zero-watermarking registration and detection method for HEVC video streaming against requantization transcoding is provided. To increase an attack-resistance of a registration watermarking, the registration method firstly processes depth values corresponding to respective brightness blocks in a target video streaming with a depth binarization during constructing registration watermarking information through depth features, because the depth binarization well reflects a robustness of the registration watermarking. A first watermarking information matrix including a part of the depth values after the depth binarization is encrypted with a random matrix, so as to increase a safety of the registration watermarking. The registration method directly generates zero-watermarking through the depth features of the video streaming without modifying original carrier information and affecting a watermarking transparency.

Abstract: A vapor chamber structure includes an extruded aluminum case having a bottom plate and plural first separating units, an extruded aluminum cover combined with the extruded aluminum case correspondingly and having a top plate and plural second separating units, and a working fluid filled in an interior formed by the extruded aluminum case and the extruded aluminum cover. Each first separating unit includes plural first fins. A first groove is disposed between adjacent first fins. Each second separating unit includes plural second fins. A second groove is disposed between adjacent second fins. Each second separating unit is disposed between adjacent first separating units. The first grooves are individually interlaced with the adjacent second grooves. Thus, the heat exchange between the vaporized working fluid and the gas in adjacent grooves can be performed, which improves the efficiency of heat transfer.

Abstract: A system and method for providing a post-passivation and underbump metallization is provided. An embodiment comprises a post-passivation layer that is larger than an overlying underbump metallization. The post-passivation layer extending beyond the underbump metallization shields the underlying layers from stresses generated from mismatches of the materials' coefficient of thermal expansion.

Abstract: An objective assessment method for a stereoscopic image quality combined with manifold characteristics and binocular characteristics trains a matrix after dimensionality reduction and whitening obtained from natural scene plane images through an orthogonal locality preserving projection algorithm, for obtaining a best mapping matrix. Image blocks, not important for visual perception, are removed. After finishing selecting the image blocks, through the best mapping matrix, manifold characteristic vectors of the image blocks are extracted, and a structural distortion of a distorted image is measured according to a manifold characteristic similarity. Considering influences of an image luminance variation on human eyes, a luminance distortion of the distorted image is calculated according to a mean value of the image blocks.

Abstract: A video quality objective assessment method based on a spatiotemporal domain structure firstly combines a spatiotemporal domain gradient magnitude and color information for calculating a spatiotemporal domain local similarity, and then uses variance fusion for spatial domain fusion. The spatiotemporal domain local similarity is fused into frame-level objective quality value, and then a temporal domain fusion model is established by simulating three important global temporal effects, which are a smoothing effect, an asymmetric track effects and a recency effect, of a human visual system. Finally, the objective quality values of the distorted video sequence are obtained. By modeling the human visual temporal domain effect, the temporal domain weighting method of the present invention is able to accurately and efficiently evaluate the objective quality of the distorted video.

Abstract: The present invention relates to novel methods of treating Hepatitis B Virus by administering a KDM5 inhibitor.

Abstract: A rapid autofocus method for a stereo microscope includes steps of: calculating a disparity of each of stereo microscopic images in a stereo microscopic calibration image sequence; extracting a clear stereo microscopic image sequence from the stereo microscopic calibration image sequence; then, finding out a largest disparity and a smallest disparity among the disparities of all the stereo microscopic images in the clear stereo microscopic image sequence; at a chosen magnification, arbitrarily acquiring a stereo microscopic image; finally, determining a disparity range according to the disparity of the acquired stereo microscopic image, the largest disparity and the smallest disparity, and realizing an autofocus of a target object in the acquired stereo microscopic images. The disparity range is obtained via once off-line calibration at the same magnification, and applicable to the autofocus at an arbitrary timing.

Abstract: A method for assessing an objective quality of a stereoscopic video based on reduced time-domain weighting, which considers a time domain perception redundant characteristic of human eyes during a video perception, includes steps of: through a motion intensity mean value and a motion intensity variance of an undistorted stereoscopic video and the motion intensity mean value and the motion intensity variance of each frame group, determining a motion intensity level of each frame group of the undistorted stereoscopic video; for the frame groups having different motion intensity levels, selecting undistorted reduced stereoscopic images through different frame extracting strategies with different densities; measuring a quality of a simultaneous distorted reduced stereoscopic image relative to the undistorted reduced stereoscopic image; through weighting each quality of the simultaneous distorted reduced stereoscopic image relative to the undistorted reduced stereoscopic image, obtaining a quality of a distorted s

Abstract: An acoustic system includes a conduit, a microphone coupled to an end of the conduit, and a rigid moisture resistant barrier coupled to another end of the conduit to prevent moisture from traversing the length of the conduit towards the receiver. The moisture resistant barrier dampens an audio signal traversing the conduit. The moisture resistant barrier has a submersion rating at least equal to a 7 Ingress Protection rating.

Abstract: Replicons of genotype 6 hepatitis C virus (HCV) are provided. These replicons contain adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 6 replicons and methods of using these replicons to screen antiviral agents are also provided.