Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.

Abstract: The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention provides a method for automatic identification of the clock frequency of a system clock (15) for the configuration of a peripheral device (12), having the following steps: generation of a secondary clock (16) at a predetermined clock frequency; application of the system clock (15) and of the secondary clock (16) to a host (10); application of the system clock (15) and of the secondary clock (16) to the peripheral device (12); determination of the clock frequency of the system clock (15) in the peripheral device (12) by means of the secondary clock (16); and configuration of the peripheral device (12) using the determined system clock (15).

Abstract: The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same.

Abstract: The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.

Abstract: The present invention provides methods for fabricating semiconductor structures and devices, particularly ultra-shallow doped semiconductor structures exhibiting low electrical resistance. Methods of the present invention use modification of the composition of semiconductor surfaces to allow fabrication of a doped semiconductor structure having a selected dopant concentration depth profile, which provides useful junctions and other device components in microelectronic and nanoelectronic devices, such as transistors in high density integrated circuits. Surface modification in the present invention also allows for control of the concentration and depth profile of defects, such as interstitials and vacancies, in undersaturated semiconductor materials.

Abstract: A hydraulic circuit for controlling the application of pressurized cooling fluid to the clutches of a dual clutch transmission including a cooling unit in fluid communication with a source of the pressurized cooling fluid and adapted to exchange heat from the cooling fluid with another media. The circuit also includes at least one regulator in fluid communication with the source of the pressurized cooling fluid and separately in fluid communication with the cooling unit, and with the clutches. The regulator is adapted to operatively provide the cooling fluid to the clutches. The circuit further includes at least one control actuator adapted to selectively control the regulator to provide a first variable predetermined amount of cooling fluid from the cooling unit to the clutches as primary cooling, and to provide a second variable predetermined amount of cooling fluid from the source to the clutches thereby supplementing the cooling fluid from the cooling unit.

Abstract: The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups.

Abstract: The return pumps of brake systems with a precharging device are greatly stressed by the precharging pressure and subjected to premature wear. Significant leakage occurs in the long run which will damage the pump motors in the worst case. This is prevented by controlling the pressure fluid supply from the precharging source to the suction side of the return pump as a function of the pressure gradient in this connecting line. To this end, an electromagnetically operated on-off valve (23) with a hydraulically insertable throttle is used.

Abstract: Systems and methods for the sampling of bodily fluid from an incision in the skin include test strips which are positioned adjacent to the skin and which include features to inhibit the passage of the bodily fluid between the skin and the underside of the test strip. One system utilizes a sealing member located on the bottom surface of the test strip and positioned to provide a fluid tight seal with the skin. A second system includes a recessed surface aligned with the inlet opening of the test strip to preclude contact of the bodily fluid directly with the bottom surface of the test strip. A third system involves the use of a hydrophobic surface on the underside of the test strip to inhibit wicking of the bodily fluid along the test strip. The present invention further encompasses the combination of the foregoing sampling systems with each other, and with incising, expressing and/or testing systems and methods, particularly in a single, integrated device.

Abstract: The invention relates to a burner head (9) of an electric arc welding or cutting head, with preferably a melting wire electrode, having a contact nozzle (1) and a spring chuck (2) for releasably holding the contact nozzle (1) on the burner head (9). Both of the contact nozzle and the spring chuck (2) have corresponding means to bring about positive locking between the contact nozzle (1) and the spring chuck in the contact nozzle (1) that is supported on the burner head (9).

Abstract: A laminated packet or layered coating system is applied onto plastic eyeglasses which is composed of several superposed coating sequences of a coating of TMDS of approximately 1 &mgr;, a hardened TMDS coating of approximately 0.2 &mgr;m and a separating coating of approximately 3-5 nm. The laminated composite contains on the outside a non-hardened coating of TMDS and a cover coating approximately 10-15 nm thick on it. The separating coating is produced in a plasma using methanol. The deposition of the hardened coating of TMDS takes place in the presence of oxygen bound in alcohol.

Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.

Abstract: The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention relates to a vibration damped spacer articles having good force (torque and/or pressure and/or stress) retention, and disk drives having a damped spacer article and a rotatable storage article inserted therein.

Abstract: The present invention relates to a vibration damped spacer articles having good force (torque and/or pressure and/or stress) retention, and disk drives having a damped spacer article and a rotatable storage article inserted therein.

Abstract: In an air-cooled electrical machine having reverse cooling in a closed cooling circuit, a two-stage blade cascade for the optimum incident flow of cooling air to the rotor (4) and the rotor winding (29) is provided between a rotor cap plate (22) and a rotor shaft (28). The first blade cascade stage (30b) in the direction of flow is a deceleration cascade having pressure-generating properties, and the following blade cascade stage (30a) in the direction of flow is a deceleration cascade having deflecting properties.

Abstract: A physical layer transceiver of a home network station connected to a telephone medium has an architecture enabling adaptation of detection circuitry based on received network signals to enable reliable recovery of data signals. The physical layer transceiver includes an input amplifier that amplifies network signals according to one of 128 gain settings set by a receiver gain control signal. A signal conditioning circuit includes an envelope detector configured for outputting an envelope of the amplified received signal, and an energy detector configured for outputting an energy signal of the amplified received signals. The envelope signal and the energy signal are supplied to slicer threshold circuits, configured for outputting noise, peak, data event and energy event signals based on noise threshold, peak threshold, data transition threshold, and energy threshold signals, respectively.

Abstract: A high-speed electric machine (10), comprises a rotatably mounted rotor (11) which, separated by an air gap (14), is surrounded concentrically by a stator (12) with two winding overhangs (18,19), and comprises means (20, . . . ,29) for cooling the rotor (11) and stator (12), by means of which a cooling medium, especially cooling air, is sent on a circuit through the rotor (11) and the stator (12), and the heat picked up by the cooling medium or the cooling air in the process is extracted again in a cooler (20).

Abstract: In a gas-cooled electrical machine having an axial fan (12a) and a downstream guidance mechanism, arranged downstream of the axial fan, in order to raise the pressure of a cooling gas, the cooling gas is driven in a forced manner by means of the axial fan from an inlet area (41), which is bounded by an inner casing (21) and a partition wall (20) arranged in the radial plane of the axial fan (12a), into an outlet area (42) which is bounded by the partition wall (20) and an outer casing (37). In this case, the downstream guidance mechanism is designed as a deflection diffusor (36) in order to deflect a cooling-gas flow (39) from an essentially axial flow direction to an essentially radial flow direction.