Abstract: An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Abstract: This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.

Abstract: A door interface system for a vehicle door includes a sensor and a visual indicator. The sensor may be a proximity sensor and may be positioned proximate to the visual indicator such that it will detect an object proximate to the proximity sensor. The visual indicator may convey the position of the sensor and/or a status of the vehicle door. The door interface system is configured to control the vehicle door based at least in part on detecting an object proximate the visual indicator.

Abstract: An interchangeable electro-mechanical lock core for use with a lock device having a locked state and an unlocked state is disclosed. The interchangeable electro-mechanical lock core may include a moveable plug having a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which corresponds to the lock device being in the unlocked state. The interchangeable electro-mechanical lock core may include a core keeper moveably coupled to a lock core body. The core keeper may be positionable in a retain position wherein the core keeper extends beyond an envelope of lock core body to hold the lock core body in an opening of the lock device and a remove position wherein the core keeper is retracted relative to the envelope of the lock core body to permit removal.

Abstract: An image of a sample collection device is captured. The image of the sample collection device is analyzed to determine whether the sample collection device includes a sufficient amount of fluid sample. The image of the sample collection device is validated based on a result of the image analysis.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: The present invention pertains to a tag-free CM1 polypeptide and methods for improving homology directed repair (HDR) in a recipient cell using the same. Preferred donor template delivery vehicles include Adeno virus-associated vectors for delivering donor templates, and a preferred tag-free CM1 polypeptide called CM1tf. Isolated nucleic acids encoding tag-free CM1 polypeptides are also provided.

Abstract: A roller shade assembly includes a roller tube including a first end opposite a second end, the roller tube defining an opening longitudinally extending between the first and second ends, and an idler assembly partially received by the opening at the first end, the idler assembly including an idler housing, a plunger received by the idler housing, and a biasing member configured to apply a biasing force onto the plunger, wherein the plunger is configured to slide relative to the idler housing, and the plunger is configured to selectively engage a bracket member.

Abstract: Systems and methods for tracking unintentional high amplitude muscle movements of a user and stabilizing a handheld tool are described. The method may include detecting motion of a housing of the handheld tool when manipulated by a user while the user is performing a task with a user-assistive device attached to an attachment arm of the handheld tool, and storing the detected motion in a memory of the handheld tool as motion data. Furthermore, the method may include controlling a first motion generating mechanism and a second motion generating mechanism by generating a first motion signal and a second motion signal that respectively drive the first motion generating mechanism in a first degree of freedom and the second motion generating mechanism in a second degree of freedom to stabilize motion of the user-assistive device attached to the attachment arm of the handheld tool.

Abstract: An adhesive composition comprising a core shell vinyl ester and a urethane acrylate, which is suitable to be applied to a rough or uneven surface of a substrate to render a smooth surface. The present adhesive composition is particularly suitable to coat large objects made through additive manufacturing to form molds or prototypes.

Abstract: According to one aspect, a system and method of exchanging GRUUs (Globally Routed User Agent URI (Uniform Resource Identifier)) between a first telephony-enabled device and a second telephony enabled device using a circuit-switched message is provided. Once exchanged, the telephony enabled devices can exchange SIP (session initiated protocol) communications routed by the GRUUs. Any one of the telephony-enabled devices can add a media component to the SIP communications. According to another aspect, a system and method of generating GRUUs is provided. According to another aspect, a system and method of handing off communications to a packet switched network from a circuit switched network is provided.

Abstract: A stem sealing device for a valve can include a device body defining an annular shape; a stem seal defining an annular shape and configured to seal a gap between a valve stem of the valve and a valve body of the valve and positioned within the device body, the stem sealing device installable in and removable from the valve as an assembly without prior or subsequent removal of the stem seal; and a fastener configured to secure the device body to the valve body.

Abstract: The transmission and reception group delay in a front end structure of a mobile device may be determined using closed loop calibration. The closed loop may be a near field radiated closed loop between pairs of antennas in an antenna array of the mobile device. The delay based on time of transmission and time of reception may be measured for a plurality of pairs of antennas, from which the transmit and receive group delay within a single path may be determined. The propagation delay of the signal between antennas may be included in the group delay calibration for increased accuracy. In another implementation, a conducted closed loop, e.g., in the transceiver or in a radio frequency switching network may be used to calibrate the group delay. Pre-characterization of the delay caused by components between the closed loop and antennas may be included in the group delay calibration for increased accuracy.

Abstract: In various examples, a transaction type of a transaction from a processing resource of a plurality of processing resources sharing a bus may be determined and used to track bandwidth usage for the processing resource with respect to a time slot. Transactions that indicate usage of downstream bandwidth may be distinguished from transactions that do not indicate usage of downstream bandwidth. Bandwidth usage for a time slot may be tracked using one or more counters. The system may block or permit transactions from reaching the bus based at least on the counter exceeding a threshold value. The total allocation of bandwidth to the processing resources sharing a bus may be limited to a value that is less than a maximum capability of the bus to allow for headroom. Bandwidth coming from different lines and/or lanes and belonging to the same processing resource may be shared.

Abstract: An imaging system and methods including a gantry defining a bore and an imaging axis extending through the bore, and at least one support member that supports the gantry such that the imaging axis has a generally vertical orientation, where the gantry is displaceable with respect to the at least one support member in a generally vertical direction. The imaging system may be configured to obtain a vertical imaging scan (e.g., a helical x-ray CT scan), of a patient in a weight-bearing position. The gantry may be rotatable between a first position, in which the gantry is supported such that the imaging axis has a generally vertical orientation, and a second position, such that the imaging axis has a generally horizontal orientation. The gantry may be displaceable in a horizontal direction and the system may perform a horizontal scan of a patient or object positioned within the bore.

Abstract: A thermosetting composition comprising a crosslinkable component such as a vinyl ester and/or an unsaturated polyester, and an initiator component, such as cumene hydroperoxide or BPO or blends of cumene hydroperoxide and methyl ethyl ketone peroxide. The composition is suitable to be used in additive manufacturing to form objects such as molds or prototypes.

Abstract: An apparatus and method for radiation measurement are used to determine clearance of a rotating gas turbine component. The apparatus includes a probe body on a stationary component outward of the rotating component and a pair of sensor assemblies coupled to the probe body. Each sensor assembly includes a plurality of prisms coupled to the probe body Each prism of the plurality of prisms has a distinct angular orientation to direct radiation from the focusing lens to the rotating component surface off-axis with respect to an axis of the respective radiation source of the pair of radiation sources and with less directional variation than radiation from the respective radiation source.

Abstract: An apparatus for detecting radiation deflected from a rotating component includes a probe body on a stationary component radially outward of the rotating component; and a pair of arrival time sensors coupled to the probe body. Each arrival time sensor includes a light pipe that receives radiation deflected from the rotating component and that reduces directional variation of the radiation. A detector is optically coupled to each respective light pipe. The detector is positioned to receive the radiation with reduced directional variation from the light pipe. A method of detecting radiation from the rotating component using the apparatus determines a clearance between the rotating component (e.g., a turbomachine blade) and a stationary component (e.g., a casing).

Abstract: A method for providing a user agent (UA) with service identification data. The method includes an application server (AS) transmitting Session Initiation Protocol (SIP) data. The SIP data comprises an identifier of the AS and a service identifier for at least one service supported by the AS. The method further includes the UA receiving the SIP data.

Abstract: A method of manufacturing a heart valve prosthesis includes cutting a flat sheet of a valve material into a single-piece valve pattern having two or more valve leaflet regions and a valve skirt region. The method also includes arranging the two or more valve leaflet regions of the single-piece valve pattern into a mold for forming a leaflet belly for each of the two or more valve leaflet regions. Further, the method includes fixing, while arranged in the mold, a shape of the leaflet belly of each of two or more valve leaflet regions of the single piece-valve pattern. The method additionally includes creating a side seam by attaching two longitudinal edges of the single-piece valve pattern, to thereby form a tubular valve subassembly with two or more valve leaflets. The method includes attaching the tubular valve subassembly within a tubular frame to form a heart valve prosthesis.