Abstract: The present disclosure concerns polynucleotides and amino acids of Acidaminococcus sp. Cas12a (Cpf1) and methods for their use for genome editing in eukaryotic cells.

Abstract: This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.

Abstract: The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to credit commercial broadcasts are disclosed. Example commercial crediting apparatus disclosed herein compare first identification information and first timing information obtained from a first monitored data feed with second identification information and second timing information in a second monitored data feed to identify a first final distributor code represented in the second monitoring data feed, the first identification information and the first timing information corresponding to a first commercial represented in the first monitored data feed. Disclosed example apparatus also access data that maps a first original distributor code to the first final distributor code, identify the first commercial in lineup data based on the first original distributor code, and adjust, based on a duration of the first commercial, a duration obtained for a first media program listed in the lineup data.

Abstract: A check valve includes a valve body defining a valve bore extending from a first axial end to a second axial end, the valve body including an annular body and a cross member secured to and extending across the valve bore from the annular body on one side of the valve body to the annular body on an opposite side of the valve body, the valve bore at the cross member divided into more than one portion by the cross member; a position block extending from the cross member; a valve member positioned within the valve body and configured to rotate between an open position and a closed position; and a pivot pin extending from the valve member, engaged with the position block, and fixed with respect to the valve member; the valve member and the pivot pin configured to rotate together between the open position and the closed position.

Abstract: The present disclosure describes methods and systems for establishing a Session Initiation Protocol Session. One method includes transmitting a first message requesting authentication configuration information; in response to the first message, receiving a second message that includes the authentication configuration information; transmitting a third message that includes authentication information based upon the received authentication configuration information; receiving an authentication challenge request that is formatted according to the second protocol; and in response to receiving the authentication challenge request, transmitting an authentication response to the second network node.

Abstract: A mobile diagnostic imaging system includes a battery system and charging system. The battery system is located in the rotating portion of the imaging system, and includes one or more battery packs comprising electrochemical cells. Each battery pack includes a control circuit that controls the state of charge of each electrochemical cell, and implements a control scheme that causes the electrochemical cells to have a similar charge state. The battery system communicates with a charging system on the non-rotating portion to terminate charge when one or more of the electrochemical cells reach a full state of charge. The imaging system also includes a docking system that electrically connects the charging system to the battery system during charging and temporarily electrically disconnects the rotating and non-rotating portions during imaging, and a drive mechanism for rotating the rotating portion relative to the non-rotating portion.

Abstract: An automatically adjusting comfort method includes measuring pressure applied by a user via a pressure-sensor array, determining a pressure profile based on measurements from the pressure-sensor array, comparing the pressure profile to a first limit, determining a cumulative pressure profile over a predetermined duration, comparing the cumulative pressure profile to a second limit, and adjusting one or more of a plurality of adjusting mechanisms configured to alter the pressure profile for increased comfort of the user when the pressure profile exceeds the first limit or the second limit. An automatically adjusting comfort system includes a pressure-sensor array communicatively coupled to a controller for determining a cumulative pressure profile over time, and a plurality of adjusting mechanisms configured to alter the pressure profile to increase a user's comfort, wherein the controller automatically adjusts one or more of the plurality of adjusting mechanisms based on the cumulative pressure profile.

Abstract: A re-programmable integrated circuit (IC) includes a plurality of non-volatile memory elements, each including a fuse portion initially configured to have either a first resistance value or a second resistance value. Re-programming circuitry includes a controllable element coupled to each fuse portion and selectively operable to cause an electrical current to flow through the fuse portion sufficient to cause that fuse portion to transition to an altered state having a resistance value greater than the first and second resistance values. Reference resistance circuitry is configurable between an initial state and a re-programmed state.

Abstract: A recording head comprises a write pole extending to an air-bearing surface. A near-field transducer is positioned proximate a first side of the write pole in a down-track direction. A heatsink structure is proximate the near-field transducer and positioned between the near-field transducer and the write pole. The heatsink structure extends beyond the near-field transducer in a cross-track direction and extends in a direction normal to the air-bearing surface.

Abstract: An example includes a segment collector to: access impression records indicative of media access segments, the media access segments including start times and end times corresponding to media accessed by a panelist; and determine ones of the impression records that include a watermark corresponding to a first media platform presenting the media; a segment classifier to convert a first one of the impression records including the watermark to a converted impression record; and combine the converted impression record corresponding to the first media platform and a second impression record corresponding to a second media platform; and a media creditor to generate audience measurement metrics based on the combined impression records.

Abstract: Embodiments of the present invention comprise two or more distinct solar power systems associated with a single residence or building that together form an aggregate solar power system. Advantageously, high draw appliances can be distributed among the different systems such that the high current draw of one appliance on a first system will not negatively impact the high current draw of another high draw appliance on a second system.

Abstract: A system and method are provided for determining operational parameters for improving energy efficiency of a process. The method includes obtaining energy usage data and production and operating data generated by utilizing at least one utility in the process and using the energy data and production and operating data to generate a first principles model. The method also includes obtaining sensor data from at least one sensor coupled to equipment used during operation of the process; generating an efficiency model using at least one data driven model, the sensor data, and the first principles model; and using the efficiency model to generate an energy optimization to achieve a greenhouse gas reduction in operation of the process. The method also includes generating an output comprising at least one operation parameter value to enable adjustment of the equipment to adjust operation of the process towards the greenhouse gas reduction; and providing the output to an operational controller.

Abstract: A metallic audio speaker cover and a related method of manufacturing that has a surface with a cloth-like appearance. The metallic audio speaker cover has a base of expanded metal through which sound may pass; a pretreatment film which adheres to the expanded metal base; and one or more multi-color powder coating films that adhere to the pretreatment film. In some embodiments, the surface also has anti-microbial properties.

Abstract: A metallic audio speaker cover and a related method of manufacturing that has a surface with a cloth-like appearance. The metallic audio speaker cover has a base of expanded metal through which sound may pass; a pretreatment film which adheres to the expanded metal base; and one or more multi-color powder coating films that adhere to the pretreatment film. In some embodiments, the surface also has anti-microbial properties.

Abstract: A wearable blood pressure meter includes a semi-conformable bladder, serving as a reservoir for an incompressible fluid, and a pressure sensor. The semi-conformable bladder includes a rigid housing defining a cavity within which the incompressible fluid is rigidly constrained and an elastic membrane for elastically constraining the incompressible fluid. The elastic membrane extends across an aperture into the cavity through the rigid housing. The elastic membrane conforms to a body part at the aperture when pressed against the body part. The pressure sensor mechanically couples to the incompressible fluid to measure pressure signals emanating from an artery within the body part and which propagate through the conformable membrane and the incompressible fluid to the pressure sensor.

Abstract: A welding system includes power conversion circuitry configured to convert input power to weld power and a first housing surface. The first housing surface includes a first mating geometry configured to mate with a first complementary geometry of a first modular surface of a first modular component of the welding system.

Abstract: This invention pertains to optimized protein fusion linkers for creating multi-functional chimeric proteins and methods of using the same. Additionally, the invention pertains to chimeric proteins for use in guided endonuclease systems.

Abstract: A force sensing system for determining if a user input has occurred, the system comprising: an input channel, to receive an input from at least one force sensor; an activity detection stage, to monitor an activity level of the input from the at least one force sensor and, responsive to an activity level which may be indicative of a user input being reached, to generate an indication that an activity has occurred at the force sensor; and an event detection stage to receive said indication, and to determine if a user input has occurred based on the received input from the at least one force sensor.

Abstract: An imaging system and methods including a gantry defining a bore and an imaging axis extending through the bore, and at least one support member that supports the gantry such that the imaging axis has a generally vertical orientation, where the gantry is displaceable with respect to the at least one support member in a generally vertical direction. The imaging system may be configured to obtain a vertical imaging scan (e.g., a helical x-ray CT scan), of a patient in a weight-bearing position. The gantry may be rotatable between a first position, in which the gantry is supported such that the imaging axis has a generally vertical orientation, and a second position, such that the imaging axis has a generally horizontal orientation. The gantry may be displaceable in a horizontal direction and the system may perform a horizontal scan of a patient or object positioned within the bore.