Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: The present disclosure provides to transparent and controllable human-AI interaction via chaining of machine-learned language models. In particular, although existing language models (e.g., so-called “large language models” (LLMs)) have demonstrated impressive potential on simple tasks, their breadth of scope, lack of transparency, and insufficient controllability can make them less effective when assisting humans on more complex tasks. In response, the present disclosure introduces the concept of chaining instantiations of machine-learned language models (e.g., LLMs) together, where the output of one instantiation becomes the input for the next, and so on, thus aggregating the gains per step.

Abstract: Satellites may be integrated into a provider network for cloud-based services by utilizing a satellite-deployable computing device to execute one or more cloud services that are accessible by client devices of the provider network via respective associated Application Programming Interfaces (APIs). In some embodiments, the satellite-deployable computing device may process payload data of the satellite in accordance with one or more cloud-based services indicated in control instructions originating from a client device of the provider network. In some embodiments, the processed data may be transmitted to a ground station in accordance with one or more cloud-based services.

Abstract: A fusion cage has a first component that defines an outside surface that is configured to engage a vertebral endplate, and an interior surface. The fusion cage has a second component that defines first and second opposed surfaces. One of the first and second opposed surfaces can mate with the interior surface of the first component. The fusion cage can include vertical and lateral throughholes adapted to enhance fusion.

Abstract: A dual-layered midsole for footwear includes an internal midsole layer and an external midsole layer, which are coupled to and separated by a Strobel board. The internal midsole layer may compress and expand with the movement of a wearer of an article of footwear including the dual-layered midsole, while the external midsole may provide stability and cushion for the wearer. Materials selected for the internal and external midsole layers may provide tuned viscoelastic properties to different areas of the midsole as a function of midsole layer thickness at each sole area.

Abstract: A method for increasing a detection distance of a surface of an object illuminated by near-IR electromagnetic radiation, including: (a) directing near-IR electromagnetic radiation from a near-IR electromagnetic radiation source towards an object at least partially coated with a near-IR reflective coating that increases a near-IR electromagnetic radiation detection distance by at least 15% as measured at a wavelength in a near-IR range as compared to the same object coated with a color matched coating which absorbs more of the same near-IR radiation, where the color matched coating has a ?E color matched value of 1.5 or less when compared to the near-IR reflective coating; and (b) detecting reflected near-IR electromagnetic radiation reflected from the near-IR reflective coating. A system for detecting proximity of vehicles is also disclosed.

Abstract: A rocker recliner is disclosed that has a pair of stationary arms; a seat disposed between the arms; an ottoman; a back coupled to the seat. A full-recline linkage mechanism couples the ottoman, the seat and the back and is operable to move the ottoman, the seat and the back between a closed position, a TV position and a fully reclined position. A rocker assembly is coupled between the full-recline linkage mechanism and the stationary arms that allows the seat, back and ottoman to rock between the stationary arms in any of the closed position, the TV position or the fully reclined position.

Abstract: A retaining piece for an earpiece of an in-ear audio output device comprises a retainer portion and a cantilevered portion. The cantilevered portion comprises a coupling edge and a free edge which is substantially opposite the coupling edge. The cantilevered portion is coupled to the retainer portion at the coupling edge and is configured to engage with at least a part of an outer wall of a concha of a user's pinna. The cantilevered portion comprises a convexly curved section between the coupling edge and the free edge. When the cantilevered portion is in an engaged state, the coupling edge is more medial than the free edge.

Abstract: Embodiments of the present disclosure are drawn to systems and methods for adjusting a three-dimensional (3D) model used in metal additive manufacturing to maintain dimensional accuracy and repeatability of a fabricated 3D part. These embodiments may be used to reduce or remove geometric distortions in the fabricated 3D part. One exemplary method may include: receiving, via one or more processors, a selection made by a user; receiving a 3D model of a desired part; retrieving at least one model constant based on the user's selection; receiving an input of at least one process variable setting from a set of process variable settings; generating transformation factors based on the at least one process variable parameter and the at least one model constant; transforming the 3D model of the desired part based on the transformation factors; and generating processing instructions for fabricating the transformed 3D model of the desired part.

Abstract: Techniques are disclosed for fabricating multi-part assemblies. In particular, by forming release layers between features such as bearings or gear teeth, complex mechanical assemblies can be fabricated in a single additive manufacturing process.

Abstract: The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using data format conversion (e.g., of output(s) from generative design processes) and user interface techniques that facilitate the production of 3D models of physical structures that are readily usable with 2.5-axis subtractive manufacturing, include: modifying smooth curves, which have been fit to contours representing discrete height layers of an object, to facilitate the 2.5-axis subtractive manufacturing; preparing an editable model of the object using a parametric feature history, which includes a sketch feature, to combine extruded versions of the smooth curves to form a 3D model of the object in a boundary representation format; reshaping a subset of the smooth curves responsive to user input with respect to the sketch feature; and replaying the parametric feature history to reconstruct the 3D model of the object, as changed by the user input.

Abstract: The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment different from the infrared reflective pigment.

Abstract: Configuration of signal strength calibration offset is provided. A user interface is displayed, to a screen of a mobile device, for configuration of a signal strength offset of a wireless transceiver to a vehicle, the signal strength offset being an offset with respect to a default calibration of signal strength measurements between the wireless transceiver and the vehicle, the signal strength calibration being for use in calibrating a location of the mobile device for a passive zone with respect to the vehicle. An update to the signal strength calibration is received from the user interface. The signal strength calibration as updated is sent to the vehicle for use in locating the mobile device for the passive zone.

Abstract: An ear tip includes a body configured to be mounted onto an earbud. The body includes a first end, a second end opposite the first end, and an inner wall extending between the first and second ends. The inner wall defines and surrounds a hollow passage that is configured to conduct sound waves. The body also includes an outer wall that is connected to the inner wall at the first end and extends away from the inner wall toward the second end. The inner wall has an oblong cross-sectional shape that is configured to accommodate a corresponding nozzle on the earbud. The inner wall includes a ring that is formed of a rigid material and engages and conforms to the oblong shape of the nozzle, which inhibits improper mounting and rotation of the ear tip relative to the nozzle.

Abstract: A commercial vehicle used for parcel delivery is installed with a control module. The control module communicates wirelessly with a transmitter to give control to the vehicle operator. The vehicle operator can access the vehicle's cargo compartment through the bulkhead door and/or the rear door solely by using the transmitter as opposed to manually actuating the door latch. A door actuator is added to the bulkhead door such that when the bulkhead door is wirelessly actuated the door opens without operator assistance, and the process of the door opening does not damage the vehicle. Additionally, the vehicle operator can initiate the control module to allow a push-button start and stop of the vehicle's ignition system. Such elements contribute to time savings and cost savings for parcel delivery operators.

Abstract: A system and a method are disclosed for replacing a listing of a canceled booking for a guest user. In an embodiment, an accommodation management system receives an indication that a booking by the guest user has been canceled. The system retrieves, from an attribute database, attributes of the canceled listing and maps each attribute to a set of similar attributes in an equivalence table. The system retrieves, from a listing database, a set of comparable listings, each of which includes one or more of the mapped similar attributes and available during the same time period as the canceled booking. The system books one of the comparable listings for the guest user during the time period by populating a booking data structure with a connection between the comparable listing and the guest user.

Abstract: Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.

Abstract: Fabrics that are exhibit water repellency, abrasion resistance, and optionally flame resistance are described herein. The fabrics include a plurality of fibers (such as flame resistant fibers) and a finish that imparts water repellency and abrasion resistance to the fibers. The fabrics are free or substantially free from alkylfluoropolymers. Also described herein are garments including the fabrics.

Abstract: A system and a method are disclosed for replacing an accommodation of a canceled booking for a guest user. In an embodiment, an accommodation management system receives, from a homestay application, an indication that a booking for the accommodation in a region by the guest user over a time period has been canceled. The system retrieves a homestay listing associated with the booking and retrieves attributes of the homestay listing. The system maps each attribute to a set of similar attributes in an equivalence table. The system retrieves a set of available hotel listings in the region for the same time period and determines attributes of each available hotel listing. The system determines a set of comparable hotel listings that each include similar attributes to the homestay listing and sends a command to book a comparable hotel listing the guest user during the time period.