Abstract: A bioreactor for use on a moving platform comprises a bag. According to a first aspect, the bag defines a three-dimensional geometrical shape including at least one lower collecting vertex in which at least two edges of the geometrical shape meet at an angle which is preferably not greater than 90°. The bioreactor further includes at least one port or sensor, preferably a biomass sensor, arranged in the vicinity of the collecting vertex. According to a second aspect, the bag defines a two-dimensional geometrical shape or a three-dimensional geometrical shape. The geometrical shape includes at least one edge, in which at least two faces of the geometrical shape meet at an angle which is preferably not greater than 90°. A longitudinal port/sensor element is arranged along the edge and includes several ports and/or sensors. A bioreactor motion system comprises a moving platform and a bioreactor according to the first or second aspect.

Abstract: The invention provides a nitrogen-functionalized platinum-transition metal catalyst having the formula Pt-M-NX/C (where M is a transition element such as Fe, Co, Ni, Nb, Ta, Ir, Rh, or Ru) for use at the hydrogen electrode of a hydrogen/bromine redox flow battery. The new catalyst possesses excellent activity and durability in the HBr/Br2 environment, showing superior resistance to halide poisoning than conventional Pt/C or Pt-M/C catalysts.

Abstract: The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.

Abstract: A wall-hung toilet including a bowl, a water inlet chamber receiving water, a rim channel, a shroud surrounding at least a portion of the bowl, a rear mount, and a pocket. The rim channel is provided above the bowl and is fluidly connected to the water inlet chamber to receive the water. The rim channel includes an opening that introduces water into a rear portion of the bowl at an angle relative to vertical. The rear mount includes a mounting hole that is configured to connect the toilet to a wall via a fastener engaging the wall and the mounting hole. The pocket is formed in a side of the toilet and extends through the shroud to provide access to an interior side of the mounting hole from the side of the toilet, such that the fastener can be accessed through the pocket from the side of the toilet.

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: Implementations described herein relate to features for an integrated aftertreatment system. In one implementation, an integrated aftertreatment system comprises a casing that includes a mating flange having a first constant diameter and a catalyst component configured to mate to the mating flange of the casing. The catalyst component includes a canned body including a first portion sized to a second constant diameter to mate with the first constant diameter of the mating flange. In another implementation, an integrated aftertreatment system comprises a casing, a catalyst component positioned within the casing, a particulate filter having an outer casing with an outlet, and a particulate filter joint coupled to the outer casing of the particulate filter at the outlet. An end of the particulate filter joint is aligned with an end of the particulate filter.

Abstract: Implementations described herein relate to features for an integrated aftertreatment system. In one implementation, an integrated aftertreatment system comprises a casing that includes a mating flange having a first constant diameter and a catalyst component configured to mate to the mating flange of the casing. The catalyst component includes a canned body including a first portion sized to a second constant diameter to mate with the first constant diameter of the mating flange. In another implementation, an integrated aftertreatment system comprises a casing, a catalyst component positioned within the casing, a particulate filter having an outer casing with an outlet, and a particulate filter joint coupled to the outer casing of the particulate filter at the outlet. An end of the particulate filter joint is aligned with an end of the particulate filter.

Abstract: A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: In certain aspects, the present invention provides methods for determining whether a Her-2 positive cancer is likely to respond to treatment with a Her2-acting agent and/or whether a patient with a Her-2 positive cancer is likely to have a slow disease progression. In other aspects, the present invention is drawn to methods for determining whether a subject with a Her-2 positive cancer is unlikely to respond to treatment with at least one chemotherapeutic agent in addition to a Her2-acting agent and/or whether a patient with a Her-2 positive cancer is likely to have a fast disease progression.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: A subscriber device reports network operation conditions, such as network performance incidents, to receive feedback from the network related to the incident and available or possibly available solutions, and to produce network intelligence suitable for network planning and network performance enhancement. Reporting of network performance incidents can be characterized by location and time of occurrence, wherein this intelligence is provided by the user device. Feedback provided by the network is based on the network performance data received as part of reporting an incident. The reporting described herein enables a network operator to generate network planning intelligence based on actual network performance as experienced at the subscriber level.

Abstract: Disclosed is a method for assembling a mixer-container intended for receiving a biopharmaceutical fluid in which: a container is provided, the container including: a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to the wall, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container is provided; a drive motor located outside the container is provided; the first bearing of the container is placed so as to be spaced apart from the motor; the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: The invention relates to a connection system for releasably coupling a first body (5) with a flange (25) to a fluid-conducting system in a force-fitting manner, and the invention also relates to a connection system for releasably coupling the interior of a first fluid-conducting body (5) to the interior of a second fluid-conducting body (3) in a force-fitting manner. The second body (3) has a second end with a circumferential wall (22), a membrane contact portion (9) which can be found on the wall, and an opening (43). A retaining element (2) has a passage (35) and a peripheral outer edge (24). One side and/or the passage (35) of the retaining element (2) is coupled to the membrane (1), and an annular wall (26) is arranged on the same side, said annular wall being connected to the circumferential wall (22) of the second body (3). The other side is designed to contact the surface of the flange (25) of the first body (5).

Abstract: The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.

Abstract: The invention provides a nitrogen-functionalized platinum-transition metal catalyst having the formula Pt-M-Nx/C (where M is a transition element such as Fe, Co, Ni, Nb, Ta, Ir, Rh, or Ru) for use at the hydrogen electrode of a hydrogen/bromine redox flow battery. The new catalyst possesses excellent activity and durability in the HBr/Br2 environment, showing superior resistance to halide poisoning than conventional Pt/C or Pt-M/C catalysts.