Patents by Inventor Michael Brandt

Michael Brandt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(2,6-Dichlorophenyl)-Diarylimidazoles
    Patent number: 6946471
    Abstract: This invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and cancer related diseases.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: September 20, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Brandt, Georg Fertig, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Aluminum alloy for producing high performance shaped castings
    Publication number: 20050191204
    Abstract: An aluminum alloy for shaped castings, the alloy having the following composition ranges in weight percent: about 6.0-8.5% silicon, less than 0.4% magnesium, less than 0.1% cerium, less than 0.2% iron, copper in a range from about 0.1% to about 0.5% and/or zinc in a range from about 1% to about 4%, the alloy being particularly suited for T5 heat treatment.
    Type: Application
    Filed: January 28, 2005
    Publication date: September 1, 2005
    Inventors: Jen Lin, Cagatay Yanar, Wenping Zhang, Pal Jacobsen, Geir Grasmo, Michael Brandt, Moustapha Mbaye, Martijn Vos, Michael Glazoff, Knut Pettesen, Svein Jorgensen, Terje Johnsen
  • Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
    Publication number: 20050142192
    Abstract: Solid, pharmaceutical dosage forms of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof are disclosed. In addition, methods of use are disclosed for the treatment, inter alia, of cerebral vascular disorders, anxiety disorders; mood disorders; schizophrenia; schizophreniform disorder; schizoaffective disorder; cognitive impairment; chronic neurodegenerative disorders; inflammatory diseases; fibromyalgia; complications from herpes zoster; prevention of tolerance to opiate analgesia; withdrawal symptoms from addictive drugs; and pain.
    Type: Application
    Filed: October 8, 2004
    Publication date: June 30, 2005
    Applicant: Wyeth
    Inventors: Eric Benjamin, William Cloud, Muhammad Ashraf, Mohammed Islam, Michael Brandt, Gerald Tremblay
  • Identification of human cell lines for the production of human proteins by endogenous gene activation
    Publication number: 20050090007
    Abstract: A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
    Type: Application
    Filed: November 8, 2004
    Publication date: April 28, 2005
    Inventors: Michael Brandt, Reinhard Franze, Ulrich Pessara
  • Pressure perturbation calorimetry instruments and methods
    Patent number: 6869214
    Abstract: A calorimeter that includes a sample cell, a reference cell, a pressure system that applies a variable pressure to the sample cell, and a pressure controller that controls the pressure applied by the pressure system to the sample cell. By applying identical pressure perturbations to both the sample and reference cells over a range of temperatures, the calorimeter can be used to accurately calculate both the thermal coefficient of expansion of various substances, and the volume change of molecules undergoing a structural transition.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: March 22, 2005
    Assignee: MicroCal LLC
    Inventors: Valerian V. Plotnikov, John F. Brandts, J. Michael Brandts
  • Identification of human cell lines for the production of human proteins by endogenous gene activation
    Patent number: 6846673
    Abstract: A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: January 25, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Michael Brandt, Reinhard Franze, Ulrich Pessara
  • Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof
    Publication number: 20050004079
    Abstract: Pharmaceutical compositions for intranasal administration are provided that contain at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: and one or more pharmaceutically acceptable additives for forming a composition for intranasal administration. Also provided are methods of treating one or more conditions in a mammal associated with a glutamate abnormality that includes administering intranasally to a mammal a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 7, 2004
    Publication date: January 6, 2005
    Applicant: Wyeth
    Inventors: Eric Benjamin, Reinhardt Baudy, Michael Brandt
  • 2-(2,6-Dichlorophenyl)-Diarylimidazoles
    Publication number: 20040214874
    Abstract: 1
    Type: Application
    Filed: May 18, 2004
    Publication date: October 28, 2004
    Inventors: Michael Brandt, George Fertig, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof
    Publication number: 20040203001
    Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
    Type: Application
    Filed: January 27, 2003
    Publication date: October 14, 2004
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll, Reinhard Franze, Ulrich Pessara
  • 2-(2,6-dichlorophenyl)-diarylimidazoles
    Patent number: 6790852
    Abstract: The invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and related diseases.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: September 14, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Brandt, Georg Fertig, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Scatter factor/hepatocyte growth factor antagonist NK4 for the treatment of glioma
    Publication number: 20040110685
    Abstract: A pharmaceutical composition for the treatment of a tumor derived from glia cells of the central nervous system (CNS) of a patient, characterized in that the composition contains a pharmaceutically acceptable amount of a fragment of the hepatocyte growth factor, the fragment consisting of the N-terminal hairpin domain and the four kringle domains of the hepatocyte growth factor &agr;-chain.
    Type: Application
    Filed: August 29, 2003
    Publication date: June 10, 2004
    Inventors: Michael Brandt, Marc Brockmann, Katrin Lamszus, Apollon Papadimitriou, Christine Schuell
  • Prize assignment method and program product for bingo-type games
    Publication number: 20040048647
    Abstract: A pattern probability (302) is determined for each of a number of target patterns (301) achievable in a bingo-type game. Each pattern probability (302) comprises a probability of achieving the respective target pattern (301) in the bingo-type game. Different pattern sets are then associated with each different prize level in a desired prize distribution. The target patterns (301) and their respective pattern probabilities (302) are assigned or mapped to the different pattern sets so that the probability of achieving any target pattern included in a pattern set comprises a value approximating the desired probability of the prize level with which the pattern set is associated.
    Type: Application
    Filed: September 10, 2002
    Publication date: March 11, 2004
    Inventors: Clifton Lind, Gary L. Loebig, Jefferson C. Lind, Martin Keane, Joseph R. Enzminger, John Everett Padgett, David Michael Brandt
  • Pressure perturbation calorimetry instruments and methods
    Publication number: 20040024542
    Abstract: A calorimeter that includes a sample cell, a reference cell, a pressure system that applies a variable pressure to the sample cell, and a pressure controller that controls the pressure applied by the pressure system to the sample cell. By applying identical pressure perturbations to both the sample and reference cells over a range of temperatures, the calorimeter can be used to accurately calculate both the thermal coefficient of expansion of various substances, and the volume change of molecules undergoing a structural transition.
    Type: Application
    Filed: January 30, 2003
    Publication date: February 5, 2004
    Applicant: MicroCal, LLC
    Inventors: Valerian V. Plotnikov, John F. Brandts, J. Michael Brandts
  • 2-(2,6-dichlorophenyl)-diarylimidazoles
    Publication number: 20030199691
    Abstract: 1
    Type: Application
    Filed: April 7, 2003
    Publication date: October 23, 2003
    Inventors: Michael Brandt, Georg Fertig, Hans-Willi Krell, Thomas von Hirschheydt, Edgar Voss
  • Method for assigning prizes in a bingo-type games
    Publication number: 20030195032
    Abstract: A method includes determining a pattern probability for each of a number of target patterns achievable in a bingo-type game. Each pattern probability comprises a probability of achieving the respective target pattern in the bingo-type game. The method further includes associating or mapping different pattern sets to each different prize level in a desired prize distribution. The target patterns and their respective pattern probabilities are assigned or mapped to the different pattern sets so that the individual pattern probabilities included in each pattern set add up to the desired probability of the prize level with which the pattern set is associated.
    Type: Application
    Filed: May 21, 2003
    Publication date: October 16, 2003
    Inventors: Joseph Richard Enzminger, John Everett Padgett, David Michael Brandt, Clifton Lind, Gary L. Loebig, Jefferson C. Lind
  • Preparation of erythropoietin by endogenous gene activation
    Publication number: 20030166275
    Abstract: The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
    Type: Application
    Filed: January 29, 2003
    Publication date: September 4, 2003
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll
  • Method for assigning prizes in bingo-type games
    Patent number: 6569017
    Abstract: A method according to the invention includes determining a pattern probability for each of a number of target patterns achievable in a bingo-type game. Each pattern probability comprises a probability of achieving the respective target pattern in the bingo-type game. The method next includes associating or mapping different pattern sets to each different prize level in a desired prize distribution. The target patterns and their respective pattern probabilities are assigned or mapped to the different pattern sets so that the individual pattern probabilities included in each pattern set add up to the desired probability of the prize level with which the pattern set is associated.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: May 27, 2003
    Assignee: Multimedia Games, Inc.
    Inventors: Joseph Richard Enzminger, John Everett Padgett, David Michael Brandt, Clifton Lind, Gary L. Loebig, Jefferson C. Lind
  • Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof
    Patent number: 6555373
    Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: April 29, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll, Reinhard Franze, Ulrich Pessara
  • Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
    Patent number: 6548296
    Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: April 15, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll, Reinhard Franze, Ulrich Pessara
  • Preparation of erythropoietin by endogenous gene activation
    Patent number: 6544748
    Abstract: The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: April 8, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll