Patents by Inventor Michael E. Silver

Michael E. Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
    Patent number: 10640464
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers and/or activity modifiers.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: May 5, 2020
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
    Patent number: 10583107
    Abstract: A method for treating benign prostatic hyperplasia (BPH), prostatitis, and/or prostate cancer, including the step of administering an isothiocyanate functional surfactant to a patient affected by benign prostatic hyperplasia, prostatitis, and/or prostate cancer.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: March 10, 2020
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Inhibitors of macrophage migration inhibitory factor
    Patent number: 10583108
    Abstract: A method for reducing macrophage migration inhibitory factor (MIF or MMIF) cytokine or its biological activity, including the step of administering an isothiocyanate functional surfactant to a patient having a disease or condition wherein MIF cytokine or its biological activity is implicated in the disease or condition.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: March 10, 2020
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • METHOD FOR TREATING INFECTIOUS DISEASES WITH ISOTHIOCYANATE FUNCTIONAL COMPOUNDS
    Publication number: 20200069634
    Abstract: A method for treating an infectious disease, including the step of administering an isothiocyanate functional surfactant to a patient having an infectious disease.
    Type: Application
    Filed: June 26, 2019
    Publication date: March 5, 2020
    Inventor: Michael E. Silver
  • ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING THE SAME, AND ASSOCIATED METHODS OF USE
    Publication number: 20200061016
    Abstract: An isothiocyanate functional surfactant, wherein the protonated Corm of said surfactant is represented by the following chemical structure: wherein X includes an integer ranging from approximately 1 to approximately 25, and wherein Y includes an integer ranging from approximately 6 to approximately 25.
    Type: Application
    Filed: July 30, 2019
    Publication date: February 27, 2020
    Inventor: Michael E. Silver
  • ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING ISOTHIOCYANATE FUNCTIONAL SURFACTANTS AND ASSOCIATED METHODS FOR TREATING BIOFILMS
    Publication number: 20200062702
    Abstract: The present invention relates to methods, formulations, and compositions for the treatment of biofilms. In particular, the application discloses isothiocyanate functional surfactants either alone or combination with adjunct agents to treat biofilms.
    Type: Application
    Filed: May 14, 2019
    Publication date: February 27, 2020
    Inventor: Michael E. Silver
  • Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
    Patent number: 10561632
    Abstract: A formulation, including: (a) a first medicament, wherein the first medicament includes an isothiocyanate functional compound/surfactant; and (b) a second medicament, wherein the second medicament includes an antineoplastic agent, such as a cytotoxic antineoplastic agent and/or a targeted antineoplastic agent.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: February 18, 2020
    Assignee: The William M.Yarbrough Foundation
    Inventor: Michael E. Silver
  • INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20200038360
    Abstract: A method for reducing macrophage migration inhibitory factor (MIF or MMIF) cytokine or its biological activity, including the step of administering an isothiocyanate functional surfactant to a patient having a disease or condition wherein MIF cytokine or its biological activity is implicated in the disease or condition.
    Type: Application
    Filed: October 8, 2019
    Publication date: February 6, 2020
    Inventor: Michael E. Silver
  • ISOTHIOCYANATE FUNCTIONAL COMPOUNDS AUGMENTED WITH SECONDARY ANTINEOPLASTIC MEDICAMENTS AND ASSOCIATED METHODS FOR TREATING NEOPLASMS
    Publication number: 20200030277
    Abstract: A formulation, including: (a) a first medicament, wherein the first medicament includes an isothiocyanate functional compound/surfactant; and (b) a second medicament, wherein the second medicament includes an antineoplastic agent, such as a cytotoxic antineoplastic agent and/or a targeted antineoplastic agent.
    Type: Application
    Filed: October 8, 2019
    Publication date: January 30, 2020
    Inventor: Michael E. Silver
  • Method for treating psoriasis
    Patent number: 10532039
    Abstract: A method for treating psoriasis including the steps of applying an isothiocyanate functional surfactant to an area affected by psoriasis, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: January 14, 2020
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • METHOD FOR TREATING BENIGN PROSTATIC HYPERPLASIA (BPH), PROSTATITIS, AND PROSTATE CANCER
    Publication number: 20190365696
    Abstract: A method for treating benign prostatic hyperplasia (BPH), prostatitis, and/or prostate cancer, including the step of administering an isothiocyanate functional surfactant to a patient affected by benign prostatic hyperplasia, prostatitis, and/or prostate cancer.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 5, 2019
    Inventor: Michael E. Silver
  • Method for treating skin cancer
    Patent number: 10471039
    Abstract: A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: November 12, 2019
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • USE OF ISOTHIOCYANATE FUNCTIONAL SURFACTANTS AS NRF2 INDUCERS TO TREAT EPIDERMOLYSIS BULLOSA SIMPLEX AND RELATED DISEASES
    Publication number: 20190330145
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers and/or activity modifiers.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Inventor: Michael E. Silver
  • Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
    Patent number: 10441561
    Abstract: A method for treating benign prostatic hyperplasia (BPH), prostatitis, and/or prostate cancer, including the step of administering an isothiocyanate functional surfactant to a patient affected by benign prostatic hyperplasia, prostatitis, and/or prostate cancer.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 15, 2019
    Assignee: The William M. Yanbrough Foundation
    Inventor: Michael E. Silver
  • Inhibitors of macrophage migration inhibitory factor
    Patent number: 10434081
    Abstract: A method for reducing macrophage migration inhibitory factor (MIF or MMIF) cytokine or its biological activity, including the step of administering an isothiocyanate functional surfactant to a patient having a disease or condition wherein MIF cytokine or its biological activity is implicated in the disease or condition.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 8, 2019
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
    Patent number: 10434082
    Abstract: A formulation, including: (a) a first medicament, wherein the first medicament includes an isothiocyanate functional compound/surfactant; and (b) a second medicament, wherein the second medicament includes an antineoplastic agent, such as a cytotoxic antineoplastic agent and/or a targeted antineoplastic agent.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 8, 2019
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING THE SAME, AND ASSOCIATED METHODS OF USE
    Publication number: 20190292145
    Abstract: An isothiocyanate functional surfactant, wherein the protonated form of the surfactant includes the structure of formula (IA): wherein R1 includes the structure of formula (IIA), (IIIA), or (IVA), wherein X includes an integer ranging from approximately 0 to approximately 20, wherein R2 comprises a linear or branched aliphatic group containing approximately 8 to approximately 25 carbon atoms, and wherein R3 comprises an aliphatic or aromatic group containing approximately 1 to approximately 20 carbon atoms and at least one —N?C?S group.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 26, 2019
    Inventor: Michael E. Silver
  • ISOTHIOCYANATE FUNCTIONAL SURFACTANT AND ASSOCIATED METHOD OF USE
    Publication number: 20190284133
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Inventor: Michael E. Silver
  • Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
    Patent number: 10363236
    Abstract: An isothiocyanate functional surfactant, wherein the protonated form of said surfactant is represented by the following chemical structure: wherein X includes an integer ranging from approximately 1 to approximately 25, and wherein Y includes an integer ranging from approximately 6 to approximately 25.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: July 30, 2019
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
    Patent number: 10343990
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers and/or activity modifiers.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: July 9, 2019
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver