Patents by Inventor Michael Frey
Michael Frey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150150494Abstract: A device for performing at least one medical function on a user is proposed. The device has at least one medical functional element that is designed to perform the medical function. The medical function is selected from a diagnostic, a therapeutic and a surgical function. The device has at least one evaluation and control part that comprises at least one actuation component for controlling the medical function. The evaluation and control part has at least one casing and at least one battery receptacle. The battery receptacle comprises at least one electrical energy reservoir, more particularly at least one battery. The battery receptacle is designed to be opened irreversibly by the user for removing the energy reservoir.Type: ApplicationFiled: February 5, 2015Publication date: June 4, 2015Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Stephan-Michael Frey, Helmut Walter, Jürgen Braun, Jürgen Pfrang
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Patent number: 8987469Abstract: The present invention relates to a method for preparation of alkyl 4-[5-[bis(2 -hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoate (7) from 2-fluoro-5-nitroaniline, comprising the steps of: (a) conversion of 2-fluoro-5-nitroaniline to 5-(2-fluoro-5-nitroanilino)-5 -oxopentanoic acid (1) using glutaric anhydride, conversion of compound (1) to methylammonium 5-[2-(methylamino)-5-nitroanilino]-5-oxopentanoate (2) using methylamine; conversion of compound (2) to 5[2-(methylamino)-5-nitroanilino]-5-oxopentanoic acid (3) and condensation of compound (3) to 4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid (4); (b) esterification of the product (4) of step a) to alkyl 4-(1-methyl-5-nitro 1H-benzimidazol-2-yl)butanoate (5); (c) reduction of the product of step b) to alkyl 4-(5-amino-l-methyl-1H-benzimidazol-2-yl)butanoate (6), and (d) conversion of the product of step c) to alkyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl -1H-benzimidazol-2-yl]butanoate (7).Type: GrantFiled: July 23, 2013Date of Patent: March 24, 2015Assignee: Heyl Chemisch-pharmazeutische Fabrik GmbH & Co. KGInventors: Michael Frey, Dirk-Detlef Walther
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Publication number: 20150080690Abstract: A sensor cartridge comprising a sterile capsule. The sensor cartridge further comprises a sensor within the sterile capsule. The sensor cartridge further comprises a sensor connector connected to the sensor in an initial position. The sensor cartridge further comprises an insertion needle for inserting the sensor into a subject. The insertion needle is within the sterile capsule. The sensor cartridge further comprises a sensor mounting unit for receiving the sensor connector at a mounted position. The sensor mounting unit comprises an adhesive surface for attaching to an exterior surface of the subject. The sensor cartridge further comprises an insertion mechanism operable for actuating the insertion needle and moving the sensor connector from the initial position to the mounted position.Type: ApplicationFiled: November 26, 2014Publication date: March 19, 2015Inventors: Stephan-Michael Frey, Wolfgang Heck, Oliver Kube, Helmut Walter
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Publication number: 20150080684Abstract: A sensor insertion assembly comprising a sensor cartridge having an insertion needle and a sensor within a sterile capsule. The sensor insertion assembly further comprises an inserter comprising a chamber for receiving the sensor cartridge, wherein the inserter further comprises an insertion mechanism operable for actuating the insertion needle for inserting the sensor into a subject. The sensor cartridge is removable from the chamber. The sensor cartridge is operable for shielding the insertion needle upon removal of the sensor cartridge from the chamber.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: Stephan-Michael Frey, Oliver Kube, Helmut Walter
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Patent number: 8962170Abstract: A device for performing at least one medical function on a user is proposed. The device has at least one medical functional element that is designed to perform the medical function. The medical function is selected from a diagnostic, a therapeutic and a surgical function. The device has at least one evaluation and control part that comprises at least one actuation component for controlling the medical function. The evaluation and control part has at least one casing and at least one battery receptacle. The battery receptacle comprises at least one electrical energy reservoir, more particularly at least one battery. The battery receptacle is designed to be opened irreversibly by the user for removing the energy reservoir.Type: GrantFiled: August 26, 2011Date of Patent: February 24, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan-Michael Frey, Helmut Walter, Juergen Braun, Juergen Pfrang
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Patent number: 8961431Abstract: A lancet wheel having a rim with a plurality of lancets extending radially inward from the rim is dropped in a circular frame having a plurality of spokes forming a plurality of chambers for facilitating drop-in assembly of the modular lancet wheel with the frame. A test ring having a plurality of test sections is assembled on the frame such that one test section is located adjacent each lancet to form an integrated cartridge. Each lancet includes a lancet tip defining a capillary groove sized to collect a body fluid sample from the incision via capillary action. The lancet tip exits the chamber to form the incision in skin, the capillary groove collects the body fluid sample, the lancet tip retracts into the chamber, and a portion of the lancet contacts the test section to transfer the sample from the capillary groove to the test section to analyze the sample.Type: GrantFiled: September 28, 2009Date of Patent: February 24, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Steven N. Roe, Stephan-Michael Frey
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Patent number: 8888715Abstract: Analysis system for determining an analyte in a body fluid is presented. The system comprises a reusable analysis instrument and a magazine having a plurality of integrated sample acquisition and analyzing elements. Each element comprises a puncturing element and an analyzing element. A coupling unit couples the integrated sample acquisition and analyzing element to a drive. The magazine comprises a housing having a plurality of elongate neighboring chambers separated by two side walls running in a longitudinal. The chambers contain the integrated sample acquisition and analyzing element. The chambers have an exit opening allowing for the at least partial exiting of the puncturing element. The chambers of the magazine are accessible to a coupling element that can be formfitting coupled to the coupling structure of the puncturing element, when the puncturing element is in the chamber of the magazine and the magazine is located in a holder.Type: GrantFiled: February 25, 2010Date of Patent: November 18, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Hans List, Stephan-Michael Frey, Kai Fluegge
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Patent number: 8864664Abstract: A medical device for carrying out at least one medical function. The medical device comprises at least one control part, which can be applied to a body surface of a user, and at least one functional element, which can be inserted into a body tissue of the user at at least one insertion site. The functional element can be connected to the control part. The functional element is designed to carry out at least one medical function. The control part has at least one base part with at least one supporting surface, which faces the body surface. The base part has at least one collection channel for collecting bodily fluid emerging from the insertion site.Type: GrantFiled: August 1, 2011Date of Patent: October 21, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan-Michael Frey, Marc Arnold, Tobias Brugger, Jürgen Braun
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Patent number: 8792256Abstract: A controller for a switch and a method of operating the same. In one embodiment, the controller is configured to measure a voltage of a control terminal of the switch and select a first mode of operation if the voltage of the control terminal is greater than a threshold voltage, and a second mode of operation if the voltage of the control terminal is less than the threshold voltage.Type: GrantFiled: January 27, 2012Date of Patent: July 29, 2014Assignee: Power Systems Technologies Ltd.Inventors: Ralf Schroeder genannt Berghegger, Michael Frey
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Patent number: 8704088Abstract: An electrical connecting cable with a flexible electrical cable and with at least one electrical plug connector at one end of the cable, with the electrical cable including a bundle of conductors consisting of insulated stranded wires, a foil shield enclosing the bundle of conductors, and a protective sheath encasing the foil shield and serving as the outer surface of the cable. The plug connector includes a metallic plug connector housing, preferably a round housing, holding insulated contacts and a molded-on shield sleeve with which the stranded wires and the foil shield are connected in an electrically conductive manner. The foil shield includes at least one electrically conductive shield tape and the protective sheath includes at least one electrically non-conductive sheath tape that are both wrapped at an angle spiral-like with a lateral overlap along the stranded wires around the bundle of conductors and the shield sleeve.Type: GrantFiled: October 28, 2011Date of Patent: April 22, 2014Assignee: Coninvers GmbHInventor: Michael Frey
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Publication number: 20140084811Abstract: The present invention relates to an electronic device, the electronic device comprising at least one LED, a driving unit for applying a driving algorithm for driving the LED during normal operation, and a measurement unit for determining a forward voltage of the LED by imposing a test current to the LED, the measurement unit being programmed for determining test current characteristics taking into account said driving algorithm.Type: ApplicationFiled: September 27, 2013Publication date: March 27, 2014Applicant: MELEXIS TECHNOLOGIES NVInventors: Michael BENDER, Michael FREY
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Publication number: 20140031560Abstract: The present invention relates to a method for preparation of alkyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoate (7) from 2-fluoro-5-nitroaniline, comprising the steps of: (a) conversion of 2-fluoro-5-nitroaniline to 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid (1) using glutaric anhydride, conversion of compound (1) to methylammonium 5-[2-(methylamino)-5-nitroanilino]-5-oxopentanoate (2) using methylamine; conversion of compound (2) to 5-[2-(methylamino)-5-nitroanilino]-5-oxopentanoic acid (3) and condensation of compound (3) to 4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid (4); (b) esterification of the product (4) of step a) to alkyl 4-(1-methyl-5-nitro1H-benzimidazol-2-yl)butanoate (5); (c) reduction of the product of step b) to alkyl 4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate (6), and (d) conversion of the product of step c) to alkyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoate (7)Type: ApplicationFiled: July 23, 2013Publication date: January 30, 2014Applicant: Heyl Chemisch-pharmazeutische Fabrik GmbH & Co. KGInventors: Michael Frey, Dirk-Detlef Walther
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Patent number: 8591837Abstract: Method for the injection-molding production of a magazine having a plurality of chambers, separated by partition walls, including an outer wall formed by an outer wall of the magazine. The method uses a casting mold having an outer wall channel corresponding to the outer wall of the magazine, and partition wall channels corresponding to the partition walls, and a gate opening. A plurality of partition wall channels extend from the gate opening to the outer wall channel. The method comprises injecting a plastic compound into the gate opening. The plastic compound flows from the gate point to the partition wall channels into the outer wall channel. The plastic compound streams have a differing flow speed in alternating partition wall channels so a joint line, which is aligned with a partition wall channel, forms on the outer side of the outer wall channel.Type: GrantFiled: April 13, 2011Date of Patent: November 26, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan-Michael Frey, Hans List, Andrea Rittinghaus, Maik Schwede
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Publication number: 20130296664Abstract: A biosensor is proposed for insertion into the subcutaneous tissue of a user wherein the biosensor includes at least one flexible substrate (2) and at least one electrode (5) on at least one surface (9) of the substrate and at least one contacting element (3). The contacting element is connected to the electrode. The substrate has at least one kink (4), at which the substrate is at least partly kinked such that the surface is subdivided into at least two interconnected outer surfaces (9a, 9b, 9c).Type: ApplicationFiled: June 28, 2013Publication date: November 7, 2013Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Stephan-Michael Frey, Oliver Kube
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Publication number: 20130237881Abstract: Instrument for producing a sample of body liquid for analysis by piercing the skin with a lancing element having a skin piercing tip. The instrument has a housing and a lancing drive for driving a lancing element connected thereto in a puncturing movement. A pressure ring surrounds a skin contact opening and is adapted for pressing against the skin such that the skin bulges into the opening for promoting expression of body fluid. The skin contact opening has an opening area corresponding to a circle with a diameter of at least 3 mm and at most 8 mm, and the instrument comprises a pressing force control device for controlling the pressing force between the pressure ring and the skin at the time of triggering the puncturing movement, to be at least 3 N and at most 8 N.Type: ApplicationFiled: April 29, 2013Publication date: September 12, 2013Applicant: Roche Diagnostics Operations, Inc.Inventors: Uwe KRAEMER, Volker ZIMMER, Wolfgang ROEDEL, Hans LIST, Stephan-Michael FREY, Christian HOERAUF, Paul PATEL
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Publication number: 20130194826Abstract: A controller for a switch and a method of operating the same. In one embodiment, the controller is configured to measure a voltage of a control terminal of the switch and select a first mode of operation if the voltage of the control terminal is greater than a threshold voltage, and a second mode of operation if the voltage of the control terminal is less than the threshold voltage.Type: ApplicationFiled: January 27, 2012Publication date: August 1, 2013Applicant: Power Systems Technologies, Ltd.Inventors: Ralf Schroeder Genannt Berghegger, Michael Frey
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Patent number: 8332189Abstract: A computer-implemented method of design of ruled surfaces may comprise the step of accessing data defining guiding curves P(u) and Q(v) and a cost function ƒ(t,w). Given P(u) and Q(v), the unknown coupling is a parameterized curve s(t(s),w(s)). The method further comprises defining an objective function of the type J=J(ƒ,t,w), involving both ƒ(t,w) and coordinates t, w of the coupling curve. Then, optimizing the objective function J makes it possible to obtain the target coupling curve. Finally, a ruled surface S(s,?)=?Q(w(s))+(1??)P(t(s))is provided, according to the guiding curves P(t(s)) and Q(w(s)), composed with the coordinates t,w of the coupling curve previously obtained. In addition, the objective function is further constrained at the optimization step such that arguments t,w of the cost function ƒ(t,w) are regulated by a regulation function ?.Type: GrantFiled: June 19, 2009Date of Patent: December 11, 2012Assignee: Dassault SystemesInventors: Jean-Francois Rameau, Jean Saloux, Pascal Sebah, David Bonner, Michael Frey
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Patent number: 8263019Abstract: A measurement system is provided which comprises an analysis device with at least one of a measurement function and a sample collection function, and also at least one magazine configured to receive at least one consumer element therein. The magazine comprises a magazine housing having a pair of openings. The magazine is designed as an exchangeable magazine that can be selectively operatively connected to the analysis device. The analysis device further comprises a closure mechanism having at least one sealing element which is designed to convey at least one consumer element from one of the openings. The sealing element is further configured to sealingly close the openings of the magazine when the sealing element is disposed therein.Type: GrantFiled: March 25, 2008Date of Patent: September 11, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Hans List, Stephan-Michael Frey, Volker Zimmer
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Publication number: 20120103647Abstract: An electrical connecting cable with a flexible electrical cable and with at least one electrical plug connector at one end of the cable, with the electrical cable including a bundle of conductors consisting of insulated stranded wires, a foil shield enclosing the bundle of conductors, and a protective sheath encasing the foil shield and serving as the outer surface of the cable. The plug connector includes a metallic plug connector housing, preferably a round housing, holding insulated contacts and a molded-on shield sleeve with which the stranded wires and the foil shield are connected in an electrically conductive manner. The foil shield includes at least one electrically conductive shield tape and the protective sheath includes at least one electrically non-conductive sheath tape that are both wrapped at an angle spiral-like with a lateral overlap along the stranded wires around the bundle of conductors and the shield sleeve.Type: ApplicationFiled: October 28, 2011Publication date: May 3, 2012Applicant: CONINVERS GMBHInventor: Michael FREY
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Publication number: 20120059231Abstract: A device for performing at least one medical function on a user is proposed. The device has at least one medical functional element that is designed to perform the medical function. The medical function is selected from a diagnostic, a therapeutic and a surgical function. The device has at least one evaluation and control part that comprises at least one actuation component for controlling the medical function. The evaluation and control part has at least one casing and at least one battery receptacle. The battery receptacle comprises at least one electrical energy reservoir, more particularly at least one battery. The battery receptacle is designed to be opened irreversibly by the user for removing the energy reservoir.Type: ApplicationFiled: August 26, 2011Publication date: March 8, 2012Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Stephan-Michael Frey, Helmut Walter, Jürgen Braun, Jürgen Pfrang