Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)—N—(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: Systems, apparatus, methods, and non-transitory media for providing multiple items for purchase to consumers are discussed herein. Some embodiments may include a system including circuitry configured to initiate an add-to-order session timer subsequent to the primary purchase of a first item using transaction data of the consumer. The add-to-order session timer may indicate a period of time in which one or more additional items may selected for purchase using the same transaction data as the primary purchase. In some embodiments, the system may be further configured to provide incentives to the consumer for selecting an additional item prior to expiration of the add-to-order session timer.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: Building environment data collection systems and methods are described. According to one aspect, a system includes a plurality of sensor devices which store different types of environment data, a base system comprising a plurality of interface devices configured to receive the environment data from the sensor devices, storage circuitry configured to store the environment data, and communications circuitry configured to implement communications, and a user interface apparatus comprising communications circuitry configured to communicate with the communications circuitry of the base system, a user interface configured to receive user inputs during installation of the sensor devices, and processing circuitry configured to control the user interface to generate the displayed information and to process the user inputs received via the user interface, and wherein different ones of the sensor devices are configured to generate the different types of environment data as a result of the user inputs.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: A manhole cover including: a frame located at the edges of the manhole cover which completely surrounds the manhole cover; a plurality of slats that are spaced apart and parallel to each other; a plurality of lateral bracings that are spaced apart and parallel to each other, wherein the lateral bracings are perpendicular to the slats; and a hinged access portion located in the center of the manhole cover that is connected to a main portion of the manhole cover by a hinge, and all edges of the hinged access portion are spaced away from the frame.

Abstract: Systems, apparatus, methods, and non-transitory media for providing multiple items for purchase to consumers are discussed herein. Some embodiments may include a system including circuitry configured to initiate an add-to-order session timer subsequent to the primary purchase of a first item using transaction data of the consumer. The add-to-order session timer may indicate a period of time in which one or more additional items may selected for purchase using the same transaction data as the primary purchase. In some embodiments, the system may be further configured to provide incentives to the consumer for selecting an additional item prior to expiration of the add-to-order session timer.

Abstract: An atomtronic (e.g., ultra-cold-matter physics or ion-trap) system includes a vacuum-cell structure, an integrated-circuit package with a pin-grid array, and a socket for interfacing the integrated-circuit package with external control and monitoring systems. After pins of the pin-grid array are inserted into holes of plates in the socket, the plates are moved in opposite directions so that contacts within the holes clamp in place the pins, providing electrical connections. The in-place clamping avoids stress at the seal between the integrated circuit package and the vacuum cell structure; thus, stress that could otherwise compromise the vacuum seal is avoided so as to yield a more reliable vacuum.

Abstract: A submersible pumping system for use in producing wellbore fluids from a wellbore within a subterranean formation includes a motor and a pump driven by the motor to produce the wellbore fluids. The pumping system further includes a self-supporting power cable connected to the pump. The self-supporting power cable includes a plurality of conductors and a plurality of strength members. A method of deploying and retrieving a submersible pumping system in a wellbore includes the steps of connecting a wireline to the submersible pumping system, connecting a self-supporting power cable to the submersible pumping system, lowering the submersible pumping system into the wellbore while the weight of the submersible pumping system is borne by the wireline.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: A cold-atom cell is formed by machining a block of silicon to define sites for an atom source chamber, an atom manipulation chamber, and an ion-pump chamber. A polished silicon panel is frit-bonded to an unpolished (due to machining) chamber wall (which would be difficult and costly to polish). The polished panel can then serve as a reflector or a sight for anodic bonding. A solid-phase atom source provides for vapor phase atoms in the source chamber. The source chamber also includes carbon and gold to regulate the atom pressure by sorbing and desorbing thermal atoms. The atom manipulation chamber includes components for magneto-optical trap and an atom chip, e.g., for forming a Bose-Einstein condensate. The ion-pump chamber serves as the site for an ion pump. By integrating the ion pump into the body of the cold-atom cell, a more compact, reliable, and robust cold-atom cell is achieved.

Abstract: An ultra-high vacuum (UHV) system includes a UHV cell and an ion pump to maintain the UHV in the UHV cell. The ion pump has a GCC (glass, ceramic, or crystalline) housing. An interior wall of the ion-pump housing serves as an anode or bears a coating that serves as an anode. At least one cathode is disposed with respect to the housing so that it can cooperate with the anode to form an electric field for establishing a Penning trap. The GCC housing defines a flow channel that extends radially through the anode so that a molecule can flow directly into the most ionizing region of a Penning trap.

Abstract: An ultra-high vacuum (UHV) system includes a UHV cell and an ion pump to maintain the UHV in the UHV cell. The ion pump has a GCC (glass, ceramic, or crystalline) housing. An interior wall of the ion-pump housing serves as an anode or bears a coating that serves as an anode. At least one cathode is disposed with respect to the housing so that it can cooperate with the anode to form an electric field for establishing a Penning trap. The GCC housing defines a flow channel that extends radially through the anode so that a molecule can flow directly into the most ionizing region of a Penning trap.

Abstract: A cold-atom cell is formed by machining a block of silicon to define sites for an atom source chamber, an atom manipulation chamber, and an ion-pump chamber. A polished silicon panel is frit-bonded to an unpolished (due to machining) chamber wall (which would be difficult and costly to polish). The polished panel can then serve as a reflector or a sight for anodic bonding. A solid-phase atom source provides for vapor phase atoms in the source chamber. The source chamber also includes carbon and gold to regulate the atom pressure by sorbing and desorbing thermal atoms. The atom manipulation chamber includes components for magneto-optical trap and an atom chip, e.g., for forming a Bose-Einstein condensate. The ion-pump chamber serves as the site for an ion pump. By integrating the ion pump into the body of the cold-atom cell, a more compact, reliable, and robust cold-atom cell is achieved.

Abstract: A pinch-off pliers possessing a canted orientation along the length. The pinch-off pliers has a first clamping unit, a second clamping unit, and an axial mechanism. The pinch-off pliers positioned along a first axis and a second axis, where the first axis is not parallel to the second axis. An intersection of the first axis and the second axis along the length of the pinch-off pliers creates a canting angle theta in the pinch-off pliers at the intersection. An intersection of a first plane and a third plane creates a second canting angle omega when having the pinch-off pliers positioned along the first axis and an intersecting fourth axis.

Abstract: A request is received from a security tool, the request relating to an event involving data records in a storage device. An application programming interface (API) is used to interface with secure storage functionality of the storage device, the secure storage functionality enabling a set of secure storage operations. A security operation is caused to be performed at the storage device involving the data records based at least in part on the request. In one aspect, the set of secure storage operations can include a direct read operation, a direct write operation, a copy-on-write operation, and a save-attempted-write operation.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.