Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: In a disclosed embodiment, an ultra-cold-matter (UCM) system includes a source cell nested within a hermetically-sealed ultra-high-vacuum (UHV) enclosure. Source particles, e.g., strontium atoms, can be generated within the source cell by heating a non-vapor-phase source material. The source cell is thermally isolated, e.g., by UHV, from the enclosure. Accordingly, heat is retained in the source cell, reducing the amount of heat that must be generated in the source cell to generate the vapor-phase source particles. Particles can exit the source cell to an UHV ultra-cold region where the source particles can be cooled to produce ultra-cold particles thermally isolated from the heat within the source cell.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output.

Abstract: A sole structure may include a protected region at least partially defined by side walls of one or more sole structure features. The sole structure may further include indicial features formed in the protected region. The indicial features may have shapes of information-conveying indicia. A sole structure master corresponding to the sole structure may have indicial elements corresponding to the indicial features in a master indicial region corresponding to the protected region. A mold corresponding to the sole structure may have indicial elements corresponding to the indicial features in a mold indicial region corresponding to the protected region. A sole structure master modeling a sole structure may have textures formed on one or more surfaces by a laser.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: A request is received from a security tool, the request relating to an event involving data records in a storage device. An application programming interface (API) is used to interface with secure storage functionality of the storage device, the secure storage functionality enabling a set of secure storage operations. A security operation is caused to be performed at the storage device involving the data records based at least in part on the request. In one aspect, the set of secure storage operations can include a direct read operation, a direct write operation, a copy-on-write operation, and a save-attempted-write operation.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-1: wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: For a premium wager, a raffle game is added to a lottery game play. All players of the base game (who purchased the add-on game or not) who achieve a pre-determined outcome receive a raffle game play which is entered into a raffle drawing at no additional cost. The raffle drawing is held, and the winning raffle outcome is identified. Winning raffle ticket recipients submit their tickets to the lottery authority for their prize. A determination is made if the add-on game was purchased with the base game play associated to the winning raffle ticket. If the add-on game was purchased with the base game play, the player receives the raffle prize.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: Technologies for securing an electronic device include trapping an attempt to access a secured system resource of the electronic device, determining a module associated with the attempt, determining a subsection of the module associated with the attempt, the subsection including a memory location associated with the attempt, accessing a security rule to determine whether to allow the attempted access based on the determination of the module and the determination of the subsection, and handling the attempt based on the security rule. The module includes a plurality of distinct subsections.

Abstract: A game of chance add-on raffle game, independent base game and a system for funding the raffle game prize payout is provided. For a premium wager, an add-on raffle game is offered to be added to a state on-line lottery game play at the time of the initial base game play purchase in one embodiment of the present invention. The add-on game play status is printed on the base game ticket. All players of the base game (who purchased the add-on game or not) who achieve a pre-determined outcome receive a raffle ticket containing a unique ticket number that will automatically be entered into the following add-on game raffle drawing at no additional cost. The raffle drawing is held, and the winning raffle numbers are identified. Winning raffle ticket recipients submit their tickets to the lottery authority for their prize.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: An approach is presented for generating a log parser. Regular expressions are received and stored in a crowd-sourced data repository. An instruction is received to create a log parser based on a sample log. The sample log is received. Matches are identified between strings of characters included in the received sample log and regular expressions included in the stored regular expressions. Each match indicates a stored regular expression is capable of parsing a string included in the sample log. Based on the identified matches, the log parser is generated so as to include the regular expressions that match the strings included in the sample log.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-1: wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output.

Abstract: For a premium wager, a raffle game is added to a lottery game play. All players of the base game (who purchased the add-on game or not) who achieve a pre-determined outcome receive a raffle game play which is entered into a raffle drawing at no additional cost. The raffle drawing is held, and the winning raffle outcome is identified. Winning raffle ticket recipients submit their tickets to the lottery authority for their prize. A determination is made if the add-on game was purchased with the base game play associated to the winning raffle ticket. If the add-on game was purchased with the base game play, the player receives the raffle prize.

Abstract: A status proxy server having a full bandwidth connection with a media server and wireless connection with a mobile end user device, receives SIP or similar protocol structured data; maintains a status indicator representative of the received structured data; and communicating at time intervals an update of the status indicator to the mobile end user device.