Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: A training pistol having an adjustable trigger with a shot—indicating laser to signify the impact of a shot which would simulate a bullet hole of a live fire pistol. In one form a trigger prep indicating system to indicate where the trigger is pressed showing the trigger finger is on the trigger and the trigger is repositioned from a rest state to a position longitudinally rearward therefrom.

Abstract: A request is received from a security tool, the request relating to an event involving data records in a storage device. An application programming interface (API) is used to interface with secure storage functionality of the storage device, the secure storage functionality enabling a set of secure storage operations. A security operation is caused to be performed at the storage device involving the data records based at least in part on the request. In one aspect, the set of secure storage operations can include a direct read operation, a direct write operation, a copy-on-write operation, and a save-attempted-write operation.

Abstract: A distribution interconnection system processes and manages interconnections into the distribution system for utilities. Various embodiments may manage and facilitate the application process. In addition, utilities may track and manage unauthorized operators, for example, via a reverse power flow detection process.

Abstract: Technologies for securing an electronic device include trapping an attempt to access a secured system resource of the electronic device, determining a module associated with the attempt, determining a subsection of the module associated with the attempt, the subsection including a memory location associated with the attempt, accessing a security rule to determine whether to allow the attempted access based on the determination of the module and the determination of the subsection, and handling the attempt based on the security rule. The module includes a plurality of distinct subsections.

Abstract: Disclosed herein is a lipid nanoparticle (LNP) composition comprising (a) an Akt inhibitor; (b) DSPC; (c) cholesterol; and (d) PEG-DMG. Also disclosed herein is a method for preparing the lipid composition using a scalable tangential flow micro-mixing technology.

Abstract: A unitary tag article is provided that may be characterized as a one-piece elastic sheet. The one-piece tag includes a fastener portion and a label portion that are formed from the same elastic sheet. The fastener portion is adapted to fasten onto an item, and the label portion is adapted to identify the item or provide information about the item. In one or more embodiments, the one-piece tag may serve a dual purpose of bundling items and identifying or providing information about said items.

Abstract: A sole structure may include a protected region at least partially defined by side walls of one or more sole structure features. The sole structure may further include indicial features formed in the protected region. The indicial features may have shapes of information-conveying indicia. A sole structure master corresponding to the sole structure may have indicial elements corresponding to the indicial features in a master indicial region corresponding to the protected region. A mold corresponding to the sole structure may have indicial elements corresponding to the indicial features in a mold indicial region corresponding to the protected region. A sole structure master modeling a sole structure may have textures formed on one or more surfaces by a laser.

Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

Abstract: Technologies for securing an electronic device include trapping an attempt to access a secured system resource of the electronic device, determining a module associated with the attempt, determining a subsection of the module associated with the attempt, the subsection including a memory location associated with the attempt, accessing a security rule to determine whether to allow the attempted access based on the determination of the module and the determination of the subsection, and handling the attempt based on the security rule. The module includes a plurality of distinct subsections.

Abstract: A unitary tag article is provided that may be characterized as a one-piece elastic sheet. The one-piece tag includes a fastener portion and a label portion that are formed from the same elastic sheet. The fastener portion is adapted to fasten onto an item, and the label portion is adapted to identify the item or provide information about the item. In one or more embodiments, the one-piece tag may serve a dual purpose of bundling items and identifying or providing information about said items.

Abstract: Technologies for securing an electronic device include trapping an attempt to access a secured system resource of the electronic device, determining a module associated with the attempt, determining a subsection of the module associated with the attempt, the subsection including a memory location associated with the attempt, accessing a security rule to determine whether to allow the attempted access based on the determination of the module and the determination of the subsection, and handling the attempt based on the security rule. The module includes a plurality of distinct subsections.

Abstract: Building environment data collection systems and methods are described. According to one aspect, a system includes a plurality of sensor devices which store different types of environment data, a base system comprising a plurality of interface devices configured to receive the environment data from the sensor devices, storage circuitry configured to store the environment data, and communications circuitry configured to implement communications, and a user interface apparatus comprising communications circuitry configured to communicate with the communications circuitry of the base system, a user interface configured to receive user inputs during installation of the sensor devices, and processing circuitry configured to control the user interface to generate the displayed information and to process the user inputs received via the user interface, and wherein different ones of the sensor devices are configured to generate the different types of environment data as a result of the user inputs.

Abstract: A lighting system operating using a digital mirror as its operative device. The digital mirror is used to shape the light which is a passed through advanced optical devices in order to produce an output.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: In a disclosed embodiment, an ultra-cold-matter (UCM) system includes a source cell nested within a hermetically-sealed ultra-high-vacuum (UHV) enclosure. Source particles, e.g., strontium atoms, can be generated within the source cell by heating a non-vapor-phase source material. The source cell is thermally isolated, e.g., by UHV, from the enclosure. Accordingly, heat is retained in the source cell, reducing the amount of heat that must be generated in the source cell to generate the vapor-phase source particles. Particles can exit the source cell to an UHV ultra-cold region where the source particles can be cooled to produce ultra-cold particles thermally isolated from the heat within the source cell.

Abstract: The invention pertains to a call management service for a communications system, configured to automatically: receive telephone call data identifying a destination end point and identifying a source end point; initiate a call-back telephone call to said source end point to set-up a first call leg responsive to receiving said telephone call data; initiate a telephone call to said destination end point to set-up a second call leg; combine said first and second call legs together thereby to provide voice communication between said source and destination end points; and transmit call leg status signals for said voice communication over a separate real-time communications connections signalling link to a communications client associated with at least one of said end points.

Abstract: A distribution interconnection system processes and manages interconnections into the distribution system for utilities. Various embodiments may manage and facilitate the application process. In addition, utilities may track and manage unauthorized operators, for example, via a reverse power flow detection process.