Patents by Inventor Michael Jensen

Michael Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific chimeric antigen receptors and encoding polynucleotides thereof
    Patent number: 9447194
    Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: September 20, 2016
    Assignee: Seattle Children's Hospital
    Inventor: Michael Jensen
  • MODIFIED HEMATOPOIETIC STEM/PROGENITOR AND NON-T EFFECTOR CELLS, AND USES THEREOF
    Publication number: 20160250258
    Abstract: Hematopoeitic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.
    Type: Application
    Filed: October 31, 2014
    Publication date: September 1, 2016
    Inventors: Colleen Delaney, Michael Jensen, Rebecca Gardner
  • METHOD OF INACTIVATING A GLUCOCORTICOID RECEPTOR GENE IN AN ISOLATED CELL
    Publication number: 20160076056
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Application
    Filed: November 20, 2015
    Publication date: March 17, 2016
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Nozzle Assembly
    Publication number: 20160047202
    Abstract: A nozzle assembly including a nozzle. The nozzle has an elongated body. The elongated body has a nozzle end at one end and a connection portion at another end. A joint section is connected with the connection portion. The joint section allows the nozzle to move axially and radially when an axial force is applied to the nozzle end.
    Type: Application
    Filed: October 26, 2015
    Publication date: February 18, 2016
    Inventor: Michael Jensen
  • Methods and Apparatus for Measuring Downhole Position and Velocity
    Publication number: 20160032711
    Abstract: An apparatus for measuring at least one of downhole position and velocity. The apparatus includes a body. A roller is connected with the body, and a plurality of sensors is connected with the body. The plurality of sensors can acquire roller data and wellbore data. The roller data and wellbore data can be used to determine at least one of the velocity and position of the apparatus. The apparatus can also have an electronic module that is in communication with the plurality of of sensors.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 4, 2016
    Inventors: Todor Sheiretov, Elizabeth Dussan V., Sarah Blake, Michael Jensen, Neil Herbst, Franz Aguirre, Robin Ewan, Ezequiel Saavedra
  • Method of inactivating a glucocorticoid receptor gene in an isolated cell
    Patent number: 9217026
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: December 22, 2015
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Chimeric immunoreceptor useful in treating human cancers
    Patent number: 9217025
    Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: December 22, 2015
    Assignee: City of Hope
    Inventor: Michael Jensen
  • Rotatable Wireline Tool of Enhanced Hydraulic Drive Consistency
    Publication number: 20150354305
    Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated. This is particularly advantageous where cutting is to be applied to downhole metal based obstructions.
    Type: Application
    Filed: August 19, 2015
    Publication date: December 10, 2015
    Inventors: Michael Jensen, Ruben Martinez
  • Apparatus, System, And Methods For Downhole Debris Collection
    Publication number: 20150345276
    Abstract: An apparatus for debris removal. The apparatus includes a debris storage housing. The debris storage housing has a velocity tube located therein. The velocity tube has a hole formed therethrough. A diverter is located on the velocity tube adjacent the hole.
    Type: Application
    Filed: June 2, 2015
    Publication date: December 3, 2015
    Inventor: Michael Jensen
  • Nozzle assembly
    Patent number: 9169718
    Abstract: A nozzle assembly including a nozzle. The nozzle has an elongated body. The elongated body has a nozzle end at one end and a connection portion at another end. A joint section is connected with the connection portion. The joint section allows the nozzle to move axially and radially when an axial force is applied to the nozzle end.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: October 27, 2015
    Assignee: Schlumberger Technology Corporation
    Inventor: Michael Jensen
  • Active desynchronization of switching converters
    Patent number: 9160170
    Abstract: A power generator park provided, which includes at least two power generator devices. Each power generator device has a switching converter for providing an electrical output power. A central controller is provided for providing switching parameter settings to the switching converters. Each of the at least two power generator devices further includes a timing unit for receiving a common time signal. The switching converter of each of the at least two power generator devices is configured for controlling at least one switching parameter in response to the respective switching parameter setting with a temporal coordination based on the common time signal.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: October 13, 2015
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Kim Hoej Jensen, Michael Jensen
  • Rotatable wireline tool of enhanced hydraulic drive consistency
    Patent number: 9127507
    Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 8, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Michael Jensen, Ruben Martinez
  • SYSTEM AND METHOD FOR REGENERATIVE BRAKING IN ELECTRIC DRIVE SYSTEM
    Publication number: 20150244290
    Abstract: The present disclosure is related to a method for regenerative braking of a machine. The machine includes an electric drive assembly. The electric drive assembly includes a generator, a motor and a direct current bus and a regenerative brake assembly disposed between them. The regenerative braking assembly includes an inverter. The method includes connecting a phase leg between the direct current bus and the inverter. The phase leg includes an inductor and an electric switch. The phase leg boosts the regenerative voltage. The boosted regenerative voltage is then fed back to control a braking torque from the motor and directed back to the generator.
    Type: Application
    Filed: May 14, 2015
    Publication date: August 27, 2015
    Applicant: Caterpillar Inc.
    Inventors: Baojun Si, Dustin Selvey, William J. Tate, Michael Jensen
  • Down hole equipment removal system
    Patent number: 9097078
    Abstract: A method for removing downhole equipment installed in a well includes introducing an equipment dissolution mixture around the downhole equipment. The dissolution mixture includes one or more chemicals and/or materials suitable for the substantial dissolution of the downhole equipment.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: August 4, 2015
    Assignee: MAERSK OLIE OG GAS A/S
    Inventors: Michael Jensen, Wilhelmus Hubertus Paulus Maria Heijnen, Engel Van Spronsen
  • HUB-BASED ELECTRONIC LOCK SYSTEMS AND DEVICES
    Publication number: 20150194002
    Abstract: Hub-based electronic lock systems and devices relate to lock or access control systems, and more particularly to electronically controlled lock systems such as may be applied to various storage enclosures or cabinets to provide secure storage of various items, equipment, materials, and/or information within the enclosures or cabinets. Certain present aspects may relate to hub and/or daisy-chained control for a plurality of electronic locks used in an electronic access control system, for inventory management using electronic locks, and/or to electronic locks with various features including display screens, access controls and tracking, and alert capabilities.
    Type: Application
    Filed: January 7, 2015
    Publication date: July 9, 2015
    Applicant: CompX International Inc.
    Inventors: Kenneth A. Kaczmarz, John B. Payson, Mitchell S. Mlynarczyk, Brock E. Robinson, John A. Garlisch, Michael Jensen, Jesse Mavromatis, Arkady Grenader
  • TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRANSDUCED T CELL SELECTION
    Publication number: 20150184128
    Abstract: A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways.
    Type: Application
    Filed: July 24, 2014
    Publication date: July 2, 2015
    Inventor: Michael JENSEN
  • DYNAMIC NATIVE ADVERTISMENT INSERTION
    Publication number: 20150154660
    Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.
    Type: Application
    Filed: December 3, 2013
    Publication date: June 4, 2015
    Applicant: Sharethrough Inc.
    Inventors: Ryan Weald, Michael Jensen
  • Nozzle Assembly
    Publication number: 20150075794
    Abstract: A nozzle assembly including a nozzle. The nozzle has an elongated body. The elongated body has a nozzle end at one end and a connection portion at another end. A joint section is connected with the connection portion. The joint section allows the nozzle to move axially and radially when an axial force is applied to the nozzle end.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 19, 2015
    Applicant: Schlumberger Technology Corporation
    Inventor: Michael Jensen
  • BISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND THERAPEUTIC USES THEREOF
    Publication number: 20150038684
    Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
    Type: Application
    Filed: February 13, 2013
    Publication date: February 5, 2015
    Applicant: Seattle Children's Hospital (dba Seattle Children's Research Institute)
    Inventor: Michael Jensen
  • IN SITU OLIGONUCLEOTIDE SYNTHESIS ON A PARAMAGNETIC SUPPORT
    Publication number: 20140350235
    Abstract: A novel method for attaching oligonucleotides to a paramagnetic solid support is disclosed. Conventional methods of attachment require that oligonucleotides be pre-synthesized with specific end modifications, which is laborious and expensive. Instead, we attached oligonucleotides to paramagnetic beads by direct synthesis of the oligonucleotides on the surface of the beads. An external magnet was used to hold the paramagnetic beads in place during solid-phase synthesis. A magnetic force was applied directly to the beads to prevent their loss, in particular, during reagent purge-to-waste steps that involved high-pressure drain or vacuum. This method can be adapted for use in any laboratory working with conventional synthesis automation, and can be employed, for example, with single columns and multi-well titer plates.
    Type: Application
    Filed: May 18, 2014
    Publication date: November 27, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. Akhras, Michael A. Jensen