Abstract: A method (50) and an assembly (10) for milling an obstruction disposed within a wellbore (W) includes a milling module (12) having a motor (22) rotating a milling bit (14), a first electronics cartridge (26) for controlling the motor based upon a motor torque value, a tractor module (16, 18) for engaging with the wellbore and providing a push force against the wellbore to urge the milling assembly in a direction of the milling bit, and a second electronics cartridge (28) for controlling a push force value of tractor module. The method involves rotating the milling bit (54) and engaging the tractor module with the wellbore (56), and adjusting, iteratively, the operation (58) based on a calculated torque value and a calculated push force value to maintain the calculated values at around a target torque value and below a push force limit value (66, 70).

Abstract: Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13R?2 specific IL13-zetakine (IL13?), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.

Abstract: A computer system has access to a database storing collaboration data for at least one collaboration having a collaboration space. The collaboration data includes data structures identifying objects displayable by a display client on a display wall and associating locations in the collaboration space with the objects. The system includes logic configured to identify available display walls, each available wall having an identification code; logic to detect user input identifying a collaboration and an identification code for one of the free display walls; and logic to enable delivery of collaboration data for the identified collaboration to a display client for the identified display wall.

Abstract: A support device including a keyboard platform and a bracket for mounting the keyboard platform a work surface to elevate the keyboard platform above the work surface. The keyboard platform is mounted on the bracket for sliding movement relative to an edge of the work surface along a horizontal fore-aft axis. The keyboard platform is mounted on the bracket for tilting movement about a tilting axis perpendicular to the fore-aft axis. The support device includes a lock movable between a locked position wherein sliding/tilting movement of the keyboard platform is prevented and an unlocked position wherein sliding/tilting movement of the keyboard platform is permitted. One aspect includes a clamp provided on the bracket and engageable with the work surface to elevate the keyboard platform above the work surface. One aspect provides a mouse platform pivotally attached to the keyboard platform and configured to support the mouse at a tilted position.

Abstract: The present invention provides a method for selectively sealing a thief zone in a hydrocarbon reservoir located in a calcium-rich formation and penetrated by a borehole comprising injecting into the thief zone a sealing fluid comprising a mixture of and hydronium ions (H+) and a source of sulfate ions (SO42?) which mixture can provide precipitation of a designated calcium sulfate compound.

Abstract: A method for seasoning food to reduce dietary sodium intakes includes seasoning the food product with sodium chloride having a mean distribution curve size of not more than approximately 20 microns. The amount of sodium chloride included in the seasoned food product to produce the desired flavor intensity takes into account that the sodium chloride exhibits a salt intensity that is greater than a salt intensity of an equal amount of sodium chloride having a mean distribution curve particle size greater than approximately 20 microns.

Abstract: The invention is a dish rack for accommodating oversized containers in an automated dish machine. The rack includes a generally porous base surrounded by upstanding sidewalls and at least a pair of notches in one sidewall or opposing sidewalls configured for receiving an edge of the an oversized container. One form of the invention includes a wire framework having a base and one or more stanchions that extend generally upwardly from the base. The notches and wire framework are configured for supporting an oversized container at an angled position within an automated dish machine to inhibit spray from being directed out of the dish machine.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: A wind turbine configuration management system, a central computer system and a method is provided. The configuration management system includes a central computer system and a wind turbine control system controlling a wind turbine. The central computer system is coupled to the wind turbine control system over a communication network. A processing unit of the central computer is configured to periodically request configuration data from the wind turbine control system, receive configuration data from the wind turbine control system and to compare the received configuration data to a stored data.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific T cells that express a viral antigen T cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting T-cells which express viral antigen. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.

Abstract: A wind park network system is provided. The network system has a first and a second networks, a first and a second wind turbines representing a first and a second network elements, a first central unit and a second central unit for transmitting messages within the first and the second networks respectively. The first and the second wind turbines are connected to the first and the second central units within the first and the second networks respectively. The first and the second central units are connected. The first and the second networks are in a star topology and operate independently from each other such that a redundant network topology for the first and the second networks is realized.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: A support device including a keyboard platform and a bracket for mounting the keyboard platform a work surface to elevate the keyboard platform above the work surface. The keyboard platform is mounted on the bracket for sliding movement relative to an edge of the work surface along a horizontal fore-aft axis. The keyboard platform is mounted on the bracket for tilting movement about a tilting axis perpendicular to the fore-aft axis. The support device includes a lock movable between a locked position wherein sliding/tilting movement of the keyboard platform is prevented and an unlocked position wherein sliding/tilting movement of the keyboard platform is permitted. One aspect includes a clamp provided on the bracket and engageable with the work surface to elevate the keyboard platform above the work surface. One aspect provides a mouse platform pivotally attached to the keyboard platform and configured to support the mouse at a tilted position.

Abstract: A power generator park provided, which includes at least two power generator devices. Each power generator device has a switching converter for providing an electrical output power. A central controller is provided for providing switching parameter settings to the switching converters. Each of the at least two power generator devices further includes a timing unit for receiving a common time signal. The switching converter of each of the at least two power generator devices is configured for controlling at least one switching parameter in response to the respective switching parameter setting with a temporal coordination based on the common time signal.

Abstract: Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13R?2 specific IL13-zetakine (IL13?), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.

Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated. This is particularly advantageous where cutting is to be applied to downhole metal based obstructions.

Abstract: A modular utility stand storage apparatus includes a plurality of components for storage/transport and utility stand operation. The storage components are stacked on top of one another in a utility stand mode. The apparatus also includes a platform which can serve as a working platform or a hand truck for transport of the various components. The stacked utility stand storage apparatus provides various working heights and the individual storage compartments are easily lifted and portable.

Abstract: The present invention provides a method for selectively sealing a thief zone in a hydrocarbon reservoir located in a calcium-rich formation and penetrated by a borehole comprising injecting into the thief zone a sealing fluid comprising a mixture of and hydronium ions (H+) and a source of sulfate ions (SO42?) which mixture can provide precipitation of a designated calcium sulfate compound.