Abstract: The present invention provides a practical method capable of substantially removing downhole equipment by dissolving it with a chemical. The method comprises introducing an equipment dissolution mixture comprising one or more chemicals and/or materials suitable for the substantial dissolution of the downhole equipment.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: A mould for manufacturing a composite part including at least one fibre reinforced matrix in particular a wind turbine blade is provide. The mould includes at least one thermal insulating core layer disposed between at least one inner laminate layer and at least one outer laminate layer and at least one heating and/or cooling means disposed in contact or in close proximity to the inner and/or outer laminate layer.

Abstract: A descaling arrangement for a dishwasher and an associated apparatus are provided. The dishwasher has a tub portion adapted to receive dishware therein, and a fluid circulation system configured to circulate dishwashing fluid about the dishware within the tub portion. A descale system is in fluid communication with the fluid circulation system. The descale system is configured to selectively introduce a descaling substance into dishwashing fluid circulated within the fluid circulation system such that the descaling substance is distributed to at least one of the tub portion and the fluid circulation system for descaling thereof. An associated method is also provided.

Abstract: A seasoning for food that provides taste enhancement and flavor potentiation is disclosed. The seasoning can be used for reducing dietary sodium intake. The portion of seasoning has a mean particle size of less than or equal to 20 microns. In one embodiment, the invention is a seasoning comprising a first seasoning component including a salt and a second seasoning component selected for at least one of complementing and reducing the amount of the first seasoning component required for flavoring a food product.

Abstract: A seasoning for reducing dietary sodium intake is disclosed. The portion of seasoning has a mean particle size of less than or equal to 20 microns. In one embodiment, the invention is a seasoning comprising a first seasoning component including a salt and a second seasoning component selected for at least one of complementing and reducing the amount of the first seasoning component required for flavoring a food product.

Abstract: An improved method and apparatus to retrieve information over a network is described.

Abstract: A wind turbine configuration management system, a central computer system and a method is provided. The configuration management system includes a central computer system and a wind turbine control system controlling a wind turbine. The central computer system is coupled to the wind turbine control system over a communication network. A processing unit of the central computer is configured to periodically request configuration data from the wind turbine control system, receive configuration data from the wind turbine control system and to compare the received configuration data to a stored data.

Abstract: A method and a control system are provided for inputting commands to a wind turbine controller during a service or maintenance procedure. A command orally input by a user is transformed into an electrical signal representing the orally input command. The electrical signal is transformed into an input command signal which is further transformed into a reproduction signal. A user is provided the reproduction signal along with a confirmation request in a form recognized by a user, such as visually or speech representation. After the user confirms the request, a signal based on the input command is sent to the wind tower controller.

Abstract: Food products for the dietary management of a diet-responsive disease or condition, a method of dietary management of a diet-responsive disease or condition, and a system for providing such food products are disclosed. In one embodiment, the system involves (a) providing the name of at least one medical professional or medical professional's office or practice for consultation by participants and, if applicable, for writing orders for food products for participants; (b) providing controlled access to a supply of food products; and (c) providing the food products to the participants. The food products can be supplied in any suitable manner. Suitable manners of providing a supply of food products include, but are not limited to providing the food products at retail outlets, such as stores that have pharmacies, and drug stores, or through a website.

Abstract: Food products for the dietary management of a diet-responsive disease or condition, a method of dietary management of a diet-responsive disease or condition, and a system for providing such food products are disclosed. In one embodiment, the system involves (a) providing the name of at least one medical professional or medical professional's office or practice for consultation by participants and, if applicable, for writing orders for food products for participants; (b) providing controlled access to a supply of food products; and (c) providing the food products to the participants. The food products can be supplied in any suitable manner. Suitable manners of providing a supply of food products include, but are not limited to providing the food products at retail outlets, such as stores that have pharmacies, and drug stores, or through a website.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human malignancy.

Abstract: The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific T cells that express a viral antigen T cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting T-cells which express viral antigen. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.

Abstract: An electrically powered rodent trap which includes a surveillance system for remote surveillance of the trap so that the trap may be operated without being attended to. A rodent which enters into the trap is killed by means of electrocution electrodes. The dead rodent is automatically dispatched from the trap, e.g. by a trapdoor, into a container or reservoir beneath the trap. The number of electrocutions and possible other data is stored by an electronic system incorporated in the trap and a signal is sent out, either by request from an external unit, or automatically to an external unit. A city rodent exterminator is capable of monitoring the status of the trap from an office location and thereby effectively tend to the trap or to a series of traps.

Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signaling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.

Abstract: The present invention provides a method of synthesizing phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linker has the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleaves to produce 5? and 3? ends that are fully biologically compatible, (iii) cleaves completely under conditions that are already used in cleavage/deprotection processes so it is fully compatible with conditions that are common in laboratories and does not require additives that necessitate further purification after cleavage, (iv) integrates easily onto commercially available synthesizers because it is compatible with standard coupling chemistry, and (v) is compatible with DNA, RNA, forward, reverse, and LNA, synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.

Abstract: The present invention provides phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linkers have the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleave to produce 5? and 3? ends that are fully biologically compatible, (iii) cleave completely under conditions that are already used in cleavage/deprotection processes so they are fully compatible with conditions that are common in laboratories and do not require additives that necessitate further purification after cleavage, (iv) integrate easily onto commercially available synthesizers because they are compatible with standard coupling chemistry, and (v) are compatible with DNA, RNA, forward, reverse, and synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.

Abstract: This invention relates to the field of metal-catalyzed olefin polymerization methods and the polymers and films prepared therefrom. In one aspect, this invention provides polyethylene and ethylene/?-olefin copolymers formed in the presence of tightly-bridged metallocene catalyst, organoaluminum cocatalyst, and a chemically-treated solid oxide, and optionally in the presence of additional cocatalysts. The resins and films prepared from these polymers exhibit high haze values, low clarity values, and a low coefficient of friction.

Abstract: Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain FvFc: receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CE7 linked by peptide, Fc represents a hinge-CH2-CH3 region of a human IgG1, and represents the intracellular signaling domain of the zeta chain of human CD3. DNA constructs encoding a chimeric T-cell receptor and a method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor are also disclosed.

Abstract: A vehicle traffic sensor for detecting and monitoring vehicular targets is presented. The sensor employs a planar design resulting in a reduced profile sensor. The sensor includes a multi-layer radio frequency board with RF components on one of the sides and both isolation and planar array antennas on the opposing side. The antennas are preferably tapered planar array antennas which include one transmit antenna and one receive antenna. The sensor also includes at least one logic or signal processing board populated with components on a first side and a ground plane on a second side positioned toward the RF componentry of the RF board to form an RF shield. The boards are housed within a housing that is permeable, at least on the side through which the antenna structures propagate.