Abstract: A system and method for implementing interactive graphical user interfaces (GUIs) for accelerated integration and manipulation of clinical trial data for generating clinical trial-related intelligence may include obtaining a clinical trial data corpus associated with candidate clinical trials; deriving a statistical model for each of the candidate clinical trials; computing a composite statistical model from the statistical models; generating a synthetic statistical model for a target clinical trial by adapting the composite statistical model; initializing a virtual simulation computing system with simulation parameters linked to the synthetic statistical model; executing, by the virtual simulation computing system, virtual simulations using the simulation parameters; generating clinical trial intelligence data including a graphical simulation artifact from the virtual simulations; providing the graphical simulation artifact to a first display section of an interactive GUI; and providing editable user interfa

Abstract: The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.

Abstract: A system serializing and deserializing models configured to (i) store a first model, wherein the first model includes a plurality of functionalities; (ii) generate a human-readable document based on the first model, wherein the human-readable document describes the first model; (iii) generate a second model based on the human-readable document, wherein the second model includes the plurality of functionalities; and (iv) perform at least one execution of the second model.

Abstract: Input context for a statistical dialog manager may be provided. Upon receiving a spoken query from a user, the query may be categorized according to at least one context clue. The spoken query may then be converted to text according to a statistical dialog manager associated with the category of the query and a response to the spoken query may be provided to the user.

Abstract: The present disclosure provides compositions comprising enzyme-based reagents, and methods using the enzyme-based reagents, for nucleic acid sequencing. The enzyme-based reagents efficiently remove sequencing read products from a first sequenced region of a template molecule, thereby reducing residual signals in a second sequenced region on the same template molecule.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air therebetween, and a plurality of tethers disposed within the bladder, each tether in the plurality of tethers having a first end coupled to the top end cap and a second end coupled to the bottom end cap, wherein when the bladder is inflated, the bladder expands axially forcing the top end cap and the bottom end cap away from one another, the plurality of tethers adapted to restrict movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, wherein, at least one of the plurality of tethers is elastic, and the inflatable structure is adapted to provide multiple support profiles that are capable of supporting compressive loading.

Abstract: The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.

Abstract: In some examples, a service provider may determine from a shift schedule that a first employee is scheduled to work a particular shift at a business within a threshold period of time. The service provider may determine, based on a location of a first mobile device of the first employee, that the first employee is unlikely to arrive at the business in time for the start of the particular shift. In response, the service provider may find a replacement employee to fill the shift of the first employee. For instance, the service provider may send the communication to a second mobile device associated with a second employee that is determined to be within a threshold distance of the business. Alternatively, if the service provider determines that the business is overstaffed on a particular day, the service provider may offer a selected employee an incentive to depart work early.

Abstract: A deployable ramp is provided for a cargo loading system of a vehicle. The ramp includes one or more rigid element having a surface for supporting a load. The ramp further includes one or more bladders defining a chamber that is fluidly connected to an outlet of a compressor. The chamber is adapted to receive a fluid from the compressor. The bladder is attached to rigid element, and the at bladder is movable to a collapsed state where the chamber has a first volume. The bladder is further movable to an expanded state where the chamber has a second volume and contains a pressurized fluid for supporting the rigid element, in response to the bladder receiving the fluid from the compressor. The second volume is higher than the first volume.

Abstract: Provided herein is a system, apparatus, and method for continuous casting of metal, and more particularly, to a mechanism for controlling the shape of a direct chill casting mold to dynamically control a profile of an ingot cast from the mold during the casting process. Embodiments may provide an apparatus for casting material including: first and second opposing side walls; first and second end walls extending between the first and second side walls, where the first and second opposing side walls and the first and second opposing end walls form a generally rectangular shaped mold cavity. At least one of the first and second opposing side walls may include two or more contact regions, where each of the two or more contact regions may be configured to be displaced relative to a straight line along the side wall.

Abstract: The present invention relates to a compound represented by formula 1 as an adenosine A2a receptor antagonist, stereoisomers thereof, pharmaceutically acceptable salts thereof, a method using the same, a medicinal use thereof, and a pharmaceutical composition including the same.

Abstract: The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a preparation method thereof, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by formula I.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: A vehicle seat includes a seat cushion, a seat back pivotally moveable between an upright position and a reclined position, and at least one upper arm support selectively moveable between a stowed position and an extended position, the at least one upper arm support adapted to provide support for an upper arm of an occupant when the seat back of the vehicle seat is in the reclined position and the at least one upper arm support is in the extended position.

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: A battery includes a housing defining a sealed chamber, a battery pack positioned within the sealed chamber, and a shape memory alloy member that is adapted to axially compress the volume within the sealed chamber to pressurize the sealed chamber to an optimal pressure, and to automatically allow axial expansion of the volume of the sealed chamber in response to an increase of the pressure within the sealed chamber to maintain the pressure within the sealed chamber at the optimal pressure.

Abstract: Mechanisms for inhibiting the transmission of media content based on frequency and exposure measurements are provided.

Abstract: The present disclosure provides compositions and related methods, e.g., for preparing immobilized nucleic acid nanostructures using compaction oligonucleotides. In some embodiments, rolling circle amplification reaction can be conducted with compaction oligonucleotides on-support or in-solution to generate concatemer molecules having multiple copies of a polynucleotide unit arranged in tandem. Each polynucleotide unit comprises a sequence-of-interest and at least one universal adaptor sequence that binds one end of a compaction oligonucleotide. The 5? and 3? regions of the compaction oligonucleotide can hybridize to the concatemer to pull together distal portions of the concatemer causing compaction of the concatemer to form a nanostructure. Nanostructures having tighter size and shape compared to concatemers generated in the absence of the compaction oligonucleotides.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air, a plurality of tethers disposed within the bladder, the inflatable structure moveable between a stowed profile and a final support profile, wherein the bladder is pressurized and expanded axially and the plurality of tethers are fully extended and restrict further movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, a pulley assembly mounted within the bottom end cap, wherein in the stowed support profile, the plurality of tethers are wound onto the pulley assembly, the pulley assembly adapted to allow selective extension of the tethers allowing axial expansion of the bladder, wherein, the inflatable structure is adapted to provide multiple intermediary support profiles capable of supporting compressive loading.

Abstract: The present disclosure relates to compositions and methods for detecting nucleic acid sequences (e.g., coding and non-coding RNAs; nuclear/genomic DNA; mtDNA; pathogen nucleic acids, etc.) in a tissue sample, specifically providing improved matrices and matrix-employing methods for performance of nucleic acid capture and amplification in a tissue sample in situ and/or in a manner that retains spatial location information for captured nucleic acids (including nucleic acid-associated macromolecules).