Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: A battery includes a housing defining a sealed chamber, a battery pack positioned within the sealed chamber, and a shape memory alloy member that is adapted to axially compress the volume within the sealed chamber to pressurize the sealed chamber to an optimal pressure, and to automatically allow axial expansion of the volume of the sealed chamber in response to an increase of the pressure within the sealed chamber to maintain the pressure within the sealed chamber at the optimal pressure.

Abstract: Mechanisms for inhibiting the transmission of media content based on frequency and exposure measurements are provided.

Abstract: The present disclosure provides compositions and related methods, e.g., for preparing immobilized nucleic acid nanostructures using compaction oligonucleotides. In some embodiments, rolling circle amplification reaction can be conducted with compaction oligonucleotides on-support or in-solution to generate concatemer molecules having multiple copies of a polynucleotide unit arranged in tandem. Each polynucleotide unit comprises a sequence-of-interest and at least one universal adaptor sequence that binds one end of a compaction oligonucleotide. The 5? and 3? regions of the compaction oligonucleotide can hybridize to the concatemer to pull together distal portions of the concatemer causing compaction of the concatemer to form a nanostructure. Nanostructures having tighter size and shape compared to concatemers generated in the absence of the compaction oligonucleotides.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air, a plurality of tethers disposed within the bladder, the inflatable structure moveable between a stowed profile and a final support profile, wherein the bladder is pressurized and expanded axially and the plurality of tethers are fully extended and restrict further movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, a pulley assembly mounted within the bottom end cap, wherein in the stowed support profile, the plurality of tethers are wound onto the pulley assembly, the pulley assembly adapted to allow selective extension of the tethers allowing axial expansion of the bladder, wherein, the inflatable structure is adapted to provide multiple intermediary support profiles capable of supporting compressive loading.

Abstract: The present disclosure relates to compositions and methods for detecting nucleic acid sequences (e.g., coding and non-coding RNAs; nuclear/genomic DNA; mtDNA; pathogen nucleic acids, etc.) in a tissue sample, specifically providing improved matrices and matrix-employing methods for performance of nucleic acid capture and amplification in a tissue sample in situ and/or in a manner that retains spatial location information for captured nucleic acids (including nucleic acid-associated macromolecules).

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: A system and method for charging and stacking electric transport devices is described. In one embodiment, an electric transport device charging system includes a charging mat including a plurality of charging terminals. The plurality of charging terminals have a first shape. The system also includes a plurality of electric transport devices. Each electric transport device has a pair of side surfaces including a plurality of connection points. The connection points on one of the side surfaces having a second shape that is configured to conform to the first shape of the plurality of charging terminals. A first electric transport device of the plurality of electric transport devices is configured to be placed on the charging mat with the plurality of charging terminals aligned with the connection points on one of the side surfaces having the second shape such that the connection points and the charging terminals fit into each other.

Abstract: Provided herein is a system, apparatus, and method for continuous casting of metal, and more particularly, to a mechanism for controlling the shape of a direct chill casting mold to dynamically control a profile of an ingot cast from the mold during the casting process. Embodiments may provide an apparatus for casting material including: first and second opposing side walls; first and second end walls extending between the first and second side walls, where the first and second opposing side walls and the first and second opposing end walls form a generally rectangular shaped mold cavity. At least one of the first and second opposing side walls may include two or more contact regions, where each of the two or more contact regions may be configured to be displaced relative to a straight line along the side wall.

Abstract: Mechanisms for inhibiting the transmission of media content based on frequency and exposure measurements are provided.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air, a plurality of tethers disposed within the bladder, the inflatable structure moveable between a stowed profile and a final support profile, wherein the bladder is pressurized and expanded axially and the plurality of tethers are fully extended and restrict further movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, a pulley assembly mounted within the bottom end cap, wherein in the stowed support profile, the plurality of tethers are wound onto the pulley assembly, the pulley assembly adapted to allow selective extension of the tethers allowing axial expansion of the bladder, wherein, the inflatable structure is adapted to provide multiple intermediary support profiles capable of supporting compressive loading.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air therebetween, and a plurality of tethers disposed within the bladder, each tether in the plurality of tethers having a first end coupled to the top end cap and a second end coupled to the bottom end cap, wherein when the bladder is inflated, the bladder expands axially forcing the top end cap and the bottom end cap away from one another, the plurality of tethers adapted to restrict movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, wherein, at least one of the plurality of tethers is elastic, and the inflatable structure is adapted to provide multiple support profiles that are capable of supporting compressive loading.

Abstract: A screening device for screening a person includes a cabin including a wall at least partly enclosing an inner space, and a sensor on at least part of the surface of the wall facing the inner space, the sensor being configured to sense the person present in the inner space. The screening device includes a projector projecting an image into the inner space to be viewed by the person, and a control device connected to the sensor and the projector and configured to operate the sensor to sense the person residing in the inner space, and drive the projector to project instructions to the person, associated with the operating of the sensor. The screening system may further include a hand luggage screening apparatus.

Abstract: A vehicle seat includes a seat cushion, a seat back pivotally moveable between an upright position and a reclined position, and at least one upper arm support selectively moveable between a stowed position and an extended position, the at least one upper arm support adapted to provide support for an upper arm of an occupant when the seat back of the vehicle seat is in the reclined position and the at least one upper arm support is in the extended position.

Abstract: The present invention relates to a novel compound having a selective HDAC6 inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a therapeutic medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a method for preparing the same, wherein the novel compound having the selective HDAC6 inhibitory activity is represented by chemical formula (I) below.

Abstract: A sleeping occupant crash protection system includes an occupant sleeping compartment positioned within an autonomous vehicle. A substantially flat platform of the occupant sleeping compartment supports an occupant reclining in a horizontal sleep position. An elastic bedsheet is positioned in direct contact with an upper surface of the platform positioned between the occupant and the platform. A sensing system is in communication with the occupant sleeping compartment and triggers deployment of a bedsheet displacement system during a vehicle rapid deceleration event.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an optical isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament, a pharmaceutical composition containing the same, and a treatment method using the composition, and a preparation method thereof. The novel compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a preventive or therapeutic method thereof, and a method for preparing novel 1,3,4-oxadiazole triazol derivative, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by following formula (I).