Abstract: The present disclosure relates to compositions and methods for detecting nucleic acid sequences (e.g., coding and non-coding RNAs; nuclear/genomic DNA; mtDNA; pathogen nucleic acids, etc.) in a tissue sample, specifically providing improved matrices and matrix-employing methods for performance of nucleic acid capture and amplification in a tissue sample in situ and/or in a manner that retains spatial location information for captured nucleic acids (including nucleic acid-associated macromolecules).

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: Provided herein is a system, apparatus, and method for continuous casting of metal, and more particularly, to a mechanism for controlling the shape of a direct chill casting mold to dynamically control a profile of an ingot cast from the mold during the casting process. Embodiments may provide an apparatus for casting material including: first and second opposing side walls; first and second end walls extending between the first and second side walls, where the first and second opposing side walls and the first and second opposing end walls form a generally rectangular shaped mold cavity. At least one of the first and second opposing side walls may include two or more contact regions, where each of the two or more contact regions may be configured to be displaced relative to a straight line along the side wall.

Abstract: A system and method for charging and stacking electric transport devices is described. In one embodiment, an electric transport device charging system includes a charging mat including a plurality of charging terminals. The plurality of charging terminals have a first shape. The system also includes a plurality of electric transport devices. Each electric transport device has a pair of side surfaces including a plurality of connection points. The connection points on one of the side surfaces having a second shape that is configured to conform to the first shape of the plurality of charging terminals. A first electric transport device of the plurality of electric transport devices is configured to be placed on the charging mat with the plurality of charging terminals aligned with the connection points on one of the side surfaces having the second shape such that the connection points and the charging terminals fit into each other.

Abstract: Mechanisms for inhibiting the transmission of media content based on frequency and exposure measurements are provided.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air therebetween, and a plurality of tethers disposed within the bladder, each tether in the plurality of tethers having a first end coupled to the top end cap and a second end coupled to the bottom end cap, wherein when the bladder is inflated, the bladder expands axially forcing the top end cap and the bottom end cap away from one another, the plurality of tethers adapted to restrict movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, wherein, at least one of the plurality of tethers is elastic, and the inflatable structure is adapted to provide multiple support profiles that are capable of supporting compressive loading.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder attached to the top and bottom end caps and configured to hold pressurized air, a plurality of tethers disposed within the bladder, the inflatable structure moveable between a stowed profile and a final support profile, wherein the bladder is pressurized and expanded axially and the plurality of tethers are fully extended and restrict further movement of the top end cap and the bottom end cap away from one another and limit axial expansion of the bladder, a pulley assembly mounted within the bottom end cap, wherein in the stowed support profile, the plurality of tethers are wound onto the pulley assembly, the pulley assembly adapted to allow selective extension of the tethers allowing axial expansion of the bladder, wherein, the inflatable structure is adapted to provide multiple intermediary support profiles capable of supporting compressive loading.

Abstract: A screening device for screening a person includes a cabin including a wall at least partly enclosing an inner space, and a sensor on at least part of the surface of the wall facing the inner space, the sensor being configured to sense the person present in the inner space. The screening device includes a projector projecting an image into the inner space to be viewed by the person, and a control device connected to the sensor and the projector and configured to operate the sensor to sense the person residing in the inner space, and drive the projector to project instructions to the person, associated with the operating of the sensor. The screening system may further include a hand luggage screening apparatus.

Abstract: A vehicle seat includes a seat cushion, a seat back pivotally moveable between an upright position and a reclined position, and at least one upper arm support selectively moveable between a stowed position and an extended position, the at least one upper arm support adapted to provide support for an upper arm of an occupant when the seat back of the vehicle seat is in the reclined position and the at least one upper arm support is in the extended position.

Abstract: The present invention relates to a novel compound having a selective HDAC6 inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a therapeutic medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a method for preparing the same, wherein the novel compound having the selective HDAC6 inhibitory activity is represented by chemical formula (I) below.

Abstract: A sleeping occupant crash protection system includes an occupant sleeping compartment positioned within an autonomous vehicle. A substantially flat platform of the occupant sleeping compartment supports an occupant reclining in a horizontal sleep position. An elastic bedsheet is positioned in direct contact with an upper surface of the platform positioned between the occupant and the platform. A sensing system is in communication with the occupant sleeping compartment and triggers deployment of a bedsheet displacement system during a vehicle rapid deceleration event.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an optical isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament, a pharmaceutical composition containing the same, and a treatment method using the composition, and a preparation method thereof. The novel compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a preventive or therapeutic method thereof, and a method for preparing novel 1,3,4-oxadiazole triazol derivative, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by following formula (I).

Abstract: A distributed inflatable touch sensing system is provided. The distributed inflatable touch sensing system includes a sensing bladder array, the sensing bladder array having a plurality of bladders, passageways, and ports in fluid communication. The system further includes a pressure regulator in fluid communication with one of the plurality of ports for regulating a pressure in the sensing bladder array. The system further includes a plurality of sensors, each in fluid communication with one of the plurality of ports, for measuring the pressure in the sensing bladder array. The system further includes a processor in communication with the plurality of sensors. The processor is configured to determine which of the plurality of bladders has been depressed by a user.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: The disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.

Abstract: A rotor for an electric motor includes a rotor core defining a first face, a second face, and an opening extending from the first face to the second face. The rotor also includes an output shaft received by the opening of the rotor core and a valve disposed within a passageway of the output shaft. The valve controls a flowrate of the coolant and is actuated into a fully opened position at a maximum operating temperature of the rotor. The valve includes a stem having a first end portion and a second end portion, a plug disposed at the first end portion of the stem, a valve seat disposed opposite to the plug, and a shape memory alloy actuator that expands to urge the stem of the valve and the plug away from the valve seat and into the fully opened position at the maximum operating temperature.