Abstract: A rotor for an electric motor includes a rotor core defining a first face, a second face, and an opening extending from the first face to the second face. The rotor also includes an output shaft received by the opening of the rotor core and a valve disposed within a passageway of the output shaft. The valve controls a flowrate of the coolant and is actuated into a fully opened position at a maximum operating temperature of the rotor. The valve includes a stem having a first end portion and a second end portion, a plug disposed at the first end portion of the stem, a valve seat disposed opposite to the plug, and a shape memory alloy actuator that expands to urge the stem of the valve and the plug away from the valve seat and into the fully opened position at the maximum operating temperature.

Abstract: The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

Abstract: A sleeping occupant crash protection system includes an occupant sleeping compartment positioned within an autonomous vehicle. A substantially flat platform of the occupant sleeping compartment supports an occupant reclining in a horizontal sleep position. An elastic bedsheet is positioned in direct contact with an upper surface of the platform positioned between the occupant and the platform. A sensing system is in communication with the occupant sleeping compartment and triggers deployment of a bedsheet displacement system during a vehicle rapid deceleration event.

Abstract: The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

Abstract: A rotor for an electric motor includes a rotor core defining a first face, a second face, and an opening extending from the first face to the second face. The rotor also includes an output shaft received by the opening of the rotor core and a valve disposed within a passageway of the output shaft. The valve controls a flowrate of the coolant and is actuated into a fully opened position at a maximum operating temperature of the rotor. The valve includes a stem having a first end portion and a second end portion, a plug disposed at the first end portion of the stem, a valve seat disposed opposite to the plug, and a shape memory alloy actuator that expands to urge the stem of the valve and the plug away from the valve seat and into the fully opened position at the maximum operating temperature.

Abstract: Provided herein is a system, apparatus, and method for venting a direct chill casting mold by venting excess casting gas and retaining oxide from atop a casting during the direct chill casting process. Methods of venting casting gas from a direct chill casting mold include: supplying the direct chill casting mold with molten metal through a transition plate; supplying a casting gas through a casting surface of the direct chill casting mold; venting the casting gas from a gas pocket in the transition plate, wherein venting the casting gas from the gas pocket in the transition plate is performed in response to a pressure of the casting gas in the gas pocket reaching a predetermined pressure.

Abstract: An incrementally assembled skin-constrained inflatable bellows system includes a top end cap, a bottom end cap, and a bellows attached to and separating the top end cap and the bottom end cap and configured to hold pressurized fluid between the top and bottom end caps. The system further includes a nozzle configured to allow fluid to enter and exit the bellows, and an inextensible skin attached to each of the top end cap, the bottom end cap, and to the bellows. The top end cap assumes a first position when the bellows is inflated via the nozzle and, when the top end cap is adjusted from the first position to a second position, the skin is configured to maintain the top end cap in the second position and constrains the bellows into a predefined rigid three-dimensional shape.

Abstract: Provided herein is a system, apparatus, and method for continuous casting of metal, and more particularly, to a mechanism for controlling the shape of a direct chill casting mold to dynamically control a profile of an ingot cast from the mold during the casting process. Embodiments may provide an apparatus for casting material including: first and second opposing side walls; first and second end walls extending between the first and second side walls, where the first and second opposing side walls and the first and second opposing end walls form a generally rectangular shaped mold cavity. At least one of the first and second opposing side walls may include two or more contact regions, where each of the two or more contact regions may be configured to be displaced relative to a straight line along the side wall.

Abstract: In some examples, a service provider may determine from a shift schedule that a first employee is scheduled to work a particular shift at a business within a threshold period of time. The service provider may determine, based on a location of a first mobile device of the first employee, that the first employee is unlikely to arrive at the business in time for the start of the particular shift. In response, the service provider may find a replacement employee to fill the shift of the first employee. For instance, the service provider may send the communication to a second mobile device associated with a second employee that is determined to be within a threshold distance of the business. Alternatively, if the service provider determines that the business is overstaffed on a particular day, the service provider may offer a selected employee an incentive to depart work early.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: Systems and methods of the present disclosure enable injury prediction using one or more processors for receiving a time-varying signal of sensor measurements from a sensor device associated with a user. The processor(s) generate time windows of the time-varying signal, including a series of the sensor measurements across a predetermined time period, and generate motion features based at least in part on the series of the sensor measurements of the time windows. The processor(s) utilize an injury risk classification machine learning model to predict an injury risk during each time window based at least in part on the motion features. An injury alert message is generated based at least in part on the injury risk being predicted; and transmitting the injury alert message to at least one user computing device.

Abstract: A system serializing and deserializing models configured to (i) store a first model, wherein the first model includes a plurality of functionalities; (ii) generate a human-readable document based on the first model, wherein the human-readable document describes the first model; (iii) generate a second model based on the human-readable document, wherein the second model includes the plurality of functionalities; and (iv) perform at least one execution of the second model.

Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.

Abstract: Provided herein is a system, apparatus, and method for continuous casting of metal, and more particularly, to a mechanism for controlling the shape of a direct chill casting mold to dynamically control a profile of an ingot cast from the mold during the casting process. Embodiments may provide an apparatus for casting material including: first and second opposing side walls; first and second end walls extending between the first and second side walls, where the first and second opposing side walls and the first and second opposing end walls form a generally rectangular shaped mold cavity. At least one of the first and second opposing side walls may include two or more contact regions, where each of the two or more contact regions may be configured to be displaced relative to a straight line along the side wall.

Abstract: A system serializing and deserializing models configured to (i) store a first model, wherein the first model includes a plurality of functionalities; (ii) generate a human-readable document based on the first model, wherein the human-readable document describes the first model; (iii) generate a second model based on the human-readable document, wherein the second model includes the plurality of functionalities; and (iv) perform at least one execution of the second model.

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy.

Abstract: Methods, techniques, apparatus, and algorithms are described for robustly measuring real-world distances using any mobile device equipped with an accelerometer and monocular camera. A general software implementation processes 2D video, precisely tracking points of interest across frames to estimate the unsealed trajectory of the device, which is used to correct the device's inertially derived trajectory. The visual and inertial trajectories are then aligned in scale space to estimate the physical distance travelled by the device and the true distance between the visually tracked points.