Abstract: The present disclosure provides [1,2,4]triazolo[4,3-b][1,2,4]triazine, [1,2,4] triazolo[4,3-b]pyridazine, and [1,2,3]triazolo[4,5-b]pyrazine derivatives, and pharmaceutically acceptable salts, solvates or prodrugs thereof, as tyrosine kinase c-MET inhibitors, which are useful as novel anticancer and/or anti-inflammatory agents.

Abstract: An example operation may include one or more of identifying a video that is related to a search topic based on previous videos that have been watched on the user device, extracting a snippet of video from among a plurality of snippets of video within the video which is related to the search topic, and outputting an identifier of the snippet of video via a user interface of a user device.

Abstract: A pharmaceutical formulation of N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide (compound 1), in particular methanesulfonic acid salt thereof, and methods of using the pharmaceutical formulation for the treatment or prevention of diseases or medical conditions mediated through mutated forms of epidermal growth factor receptor (EGER), such as various cancers, are disclosed.

Abstract: The present invention relates to a method and system for evaluating and enhancing or improving the creativity and intelligence of a user. The creativity and intelligence of the user are evaluated by generating and evaluating mathematical representations of user answers to creativity and intelligence prompts. The mathematical representations may include positions, orientations, and scales of interactive visualization inputs and the answers may be evaluated based on the fluency, originality, elaboration, and flexibility of the answers to the prompts. The creativity and intelligence of the user are enhanced through generating user learning groups of users with similar creativity levels, generating interactive assignments, generating user workspaces for the user learning groups, verifying completed interactive assignments, and assessing the completed interactive assignments.

Abstract: A system and methods for automated permissioning of medical procedures or tests, and optional health care claim generation, are disclosed. The method includes obtaining an electronic medical record for a patient, determining a clinical appropriateness of the medical procedure or test from the electronic medical record, generating a preapproval decision for the medical procedure or test, presenting the preapproval decision to the health care provider, generating a summary of how the clinical appropriateness score was determined, and transmitting the summary of the evaluation to a remote computing device.

Abstract: The present invention relates to a method and system for evaluating and enhancing or improving the creativity and intelligence of a user. The creativity and intelligence of the user are evaluated by generating and evaluating mathematical representations of user answers to creativity and intelligence prompts. The mathematical representations may include positions, orientations, and scales of interactive visualization inputs and the answers may be evaluated based on the fluency, originality, elaboration, and flexibility of the answers to the prompts. The creativity and intelligence of the user are enhanced through generating user learning groups of users with similar creativity levels, generating interactive assignments, generating user workspaces for the user learning groups, verifying completed interactive assignments, and assessing the completed interactive assignments.

Abstract: One or more hanging trash receptacles configured to be attached to a main trash container and further configured to receive pet waste and/or pet waste bags (also known as poop bags).

Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.

Abstract: A printing system comprises one or more printheads arranged to eject ink to a deposition region. Print media are held by vacuum suction against a movable support surface, which transports the print media though the deposition region. The vacuum suction is communicated from a vacuum source to the movable support surface via a vacuum plenum. An airflow control system comprises one or more dampers arranged in the vacuum plenum to control airflow between the vacuum source and the movable support surface. The dampers have an adjustable impedance to airflow through the damper. The airflow control system is configured to adjust the impedance of the damper based on a detected condition of the printing system. A detected condition of the printing system may include, for example, a sensed pressure in the vacuum plenum.

Abstract: A vital signs monitoring patch with integrated display (VSM) includes a user access layer for accessing a display section and a first printed silver-silver chloride (Ag—AgCl) electrode. A polyethylene foam layer including battery and plunger cut-outs. A printed circuit board assembly (PCBA) layer including vitals sign monitoring sensors and the battery and connected to the first and second printed Ag—AgCl electrodes. The polyethylene foam layer bonded to the user access layer and the PCBA layer. A sensor layer including reflection mode oximetry components and the second printed Ag—AgCl electrode. A hydrogel conductive adhesive to interact between a user skin and the second printed Ag—AgCl electrode. A medical tape layer bonded to the user skin and the sensor layer. A plunger connected to the PCBA layer and configured to power on the VSM, where user access of the first printed Ag—AgCl electrode completes a circuit with the second printed Ag—AgCl electrode.

Abstract: The present invention is directed to inhibitors of Kirsten Rat sarcoma virus (KRAS), and more particularly to compounds of Formula I as well as compositions comprising Formula I and methods of using the compound of Formula I for the treatment or prevention of a disease, disorder, or medical condition mediated through KRAS, especially the KRAS mutant G12C.

Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.

Abstract: The present invention is directed to inhibitors of fibroblast growth factors, and more particularly to compounds of Formula (I), as well as compositions comprising Formula (I) and methods of using the compound of Formula (I) for the treatment or prevention of a disease, disorder, or medical condition mediated through the fibroblast growth factor receptor (FGFR), especially FGFR1-4. These diseases, disorders, or medical conditions include various cancers.

Abstract: Implementations provide cold spray additive manufacturing (“CSAM”) with gas recovery in situ in an open environment without requiring part disassembly and removal to a repair facility. Recapturing and reusing gas in an open environment reduces costs, rendering CSAM more commercially viable and efficient, and avoids risk of new damage to parts from contemporary pre-existing CSAM processes. A gas recovery nozzle attaches to a supersonic nozzle and sends used gas to a gas recovery sub-system by capturing gas that is deflected on impact with the part during CSAM. Captured gas is stored for reuse. A flexible coupling controls distance from the gas recovery nozzle to a part substrate to prevent (1) nozzle clogging; (2) stationary shock wave interference with gas flow; and (3) gas flow misdirection. The gas recovery nozzle also suppresses disruptive supersonic sounds. Implementations enable capture for later reuse of supersonically-propelled gas during in-situ CSAM in open environments.

Abstract: A vital signs monitoring ring with integrated display includes a ring housing, the ring housing comprising at least two windows and a printed circuit board assembly (PCBA) layer configured to be attached to the ring housing. The PCBA layer includes a display section, a sensor section, a transmission mode oximetry measurement section configured to be in alignment with the at least two windows, a power supply, and a switch configured to power on the vital signs monitoring ring with integrated display via the power supply. The display section is configured to display physiological and action parameters associated with a user by sensing the physiological and action signals from a digit of user wearing the vital signs monitoring ring with integrated display using at least the sensor section and the transmission mode oximetry measurement section.

Abstract: A bracket assembly is provided herein. The bracket assembly includes a first projecting element extending from a base and a second projecting element extending from the base. The first projecting element and the second projecting element are separated by a receiving space configured to receive a portion of an axle element.

Abstract: The present invention relates to a method and system for evaluating and enhancing or improving the creativity and intelligence of a user. The creativity and intelligence of the user are evaluated by generating and evaluating mathematical representations of user answers to creativity and intelligence prompts. The mathematical representations may include positions, orientations, and scales of interactive visualization inputs and the answers may be evaluated based on the fluency, originality, elaboration, and flexibility of the answers to the prompts. The creativity and intelligence of the user are enhanced through generating user learning groups of users with similar creativity levels, generating interactive assignments, generating user workspaces for the user learning groups, verifying completed interactive assignments, and assessing the completed interactive assignments.

Abstract: A method, system, and computer program product for contextual generation of an ephemeral network are provided. The method detects an initiating event for network generation associated with a user of a first computing device. The method determines a duration of the initiating event. A set of network members is determined based on the initiating event and the duration. The method establishes an ephemeral network, connecting at least a portion of computing devices associated with the set of network members. The ephemeral network is terminated in response to detecting a completion event. In response to terminating the ephemeral network, member information for the set of network members is removed from the portion of the computing devices.

Abstract: According to one embodiment, a method, computer system, and computer program product for dynamically modifying interactive digital content based on viewer sentiment is provided. The present invention may include measuring, by one or more sensors, characteristics of viewers associated with a viewed portion of the interactive digital content, while the viewers are viewing the interactive digital content; inferring the sentiment of the viewers with respect to the viewed portion of the interactive digital content based on the measured characteristics; predicting content satisfying to the viewers based on the sentiment; and modifying the interactive digital content in real time based on the predicted content.

Abstract: The present invention is directed to inhibitors of Kirsten Rat sacoma virus (KRAS), and more particularly to compounds of Formula (I), as well as compositions comprising Formula I and methods of using the compound of Formula I for the treatment or prevention of a disease, disorder, or medical condition mediated through KRAS, especially the KRAS mutant G12C.