Abstract: Provided herein is A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

Abstract: An initiating processing tile generates an offload request that may include a processing tile ID, source data needed for the computation, program counter, and destination location where the computation result is stored. The offload processing tile may execute the offloaded computation. Alternatively, the offload processing tile may deny the offload request based on congestion criteria. The congestion criteria may include a processing workload measure, whether a resource needed to perform the computation is available, and an offload request buffer fullness. In an embodiment, the denial message that is returned to the initiating processing tile may include the data needed to perform the computation (read from the local memory of the offload processing tile). Returning the data with the denial message results in the same inter-processing tile traffic that would occur if no attempt to offload the computation were initiated.

Abstract: A trajectory planning system for a refueling boom includes a human-machine interface (“HMI”) device and an electronic control unit (“ECU”). The HMI device outputs electronic control signals, in response to which the ECU performs a method. The ECU accesses a three-dimensional (“3D”) boundary model of the receiver and a 3D model of the boom. The ECU calculates a boom-to-receiver relative position using the models and sensor data, and a planned trajectory between a boom tip and a receptacle on the receiver. The trajectory is calculated using the boom-to-receiver relative position and predictive artificial potential fields. A point is found on a baseline trajectory farthest from a straight line between the receptacle and boom tip, which is recorded as a temporary goal. The planned trajectory avoids contact between the boom and receiver features. The ECU executes a control action using the planned trajectory.

Abstract: A lid assembly for use with a micro puree machine including a lid, a clip mechanism, and a release mechanism. The defines an axis. The clip mechanism is movable between an inward position and an outward position relative to the axis of the lid. The release mechanism is positionable relative to the clip mechanism between a home position and a release position and is operable to move the clip mechanism between the inward position and the outward position. At times the release mechanism is positioned toward the home position, the clip mechanism is moved toward the inward position. At times the release mechanism is positioned toward the release position, the clip mechanism is moved toward the outward position. The clip lever is operable to cause the clip mechanism to engage with or disengage from the blade assembly during installation and removal of bowl assembly from a micro puree machine.

Abstract: A crank assembly for extracting an inner galley trolley from a galley bay is provided. The crank assembly comprises an output shaft configured to rotate about an axis of rotation A for actuating a trolley extraction mechanism to extract an inner galley trolley from a galley trolley bay; a crank arm configured to rotate about the axis of rotation A; a handle connected to the crank arm for rotating the crank arm about the axis of rotation A; and a clutch mechanism. The clutch mechanism is operable to selectively couple the crank arm to the output shaft to selectively transfer rotational movement of the crank arm into rotational movement of the output shaft.

Abstract: The present disclosure generally relates to removing a photoresist in semiconductor processing, and more particularly, to a cyclic etch-ash process for removing a photoresist that may be integrated into an etch process and/or etch processing tool. In an example, while a semiconductor substrate is disposed within a chamber of a semiconductor processing tool, a first opening is etched through a first dielectric layer while a photoresist is disposed over the first dielectric layer. The first dielectric layer is disposed over a second dielectric layer, and the second dielectric layer is disposed over the semiconductor substrate. After etching the first opening and while the semiconductor substrate is within the chamber, the photoresist is removed including performing a cyclic etch-ash process.

Abstract: A selective optical shutter can include a first window, a second window, and a cavity disposed between the first window and the second window. A filter can be disposed in an optical path of the optical shutter, whereby the filter blocks of one of ultraviolet (UV) light or infrared (IR) light and passes each of visible light and the other of UV light or IR light. A first liquid and a second liquid can be disposed within the cavity. The first liquid and the second liquid can be substantially immiscible with each other, whereby a liquid interface is formed between the first liquid and the second liquid. The liquid interface can be adjustable by electrowetting to selectively pass visible light or the other of UV light or IR light.

Abstract: Disclosed are genetic control circuits, cells, and methods that use a repressor polypeptide to reduce the transcription rate of an exogenous therapeutic polypeptide encoding gene in response to a change in condition.

Abstract: A surgical tool is disclosed. The surgical tool includes a functional tool, a functional tip, at least one sensor, and a control unit. The functional tool has a shaft and a distal end. The functional tip is positioned at the distal end of the housing; at least one sensor is configured to generate a first signal indicative of at least one of an acoustic signal or a vibration signal generated by the functional tool. The control unit receives the first signal, analyzes the first signal to determine tissue type in contact with the functional tip and supplies a second signal to the functional tool to control at least one operation of the functional tool based upon the tissue type in contact with the functional tip.

Abstract: Embodiments of the present disclosure relate to memory page access instrumentation for generating a memory access profile. The memory access profile may be used to co-locate data near the processing unit that accesses the data, reducing memory access energy by minimizing distances to access data that is co-located with a different processing unit (i.e., remote data). Execution thread arrays and memory pages for execution of a program are partitioned across multiple processing units. The partitions are then each mapped to a specific processing unit to minimize inter-partition traffic given the processing unit physical topology.

Abstract: A non-invasive electronic patient monitor tracks one or more physiological parameters of a patient, such as intravascular volume index (IVI), extravascular volume index (EVI), total hemoglobin (SpHb), impedance, and/or weight. The patient monitor determines if one or more of the physiological parameters are within a predetermined range. The patient monitor activates an alarm if one or more of the physiological parameters are outside the predetermined range and indicates a patient can be experiencing edema and/or heart failure, or sepsis.

Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.

Abstract: Disclosed herein are transdermal microneedling devices that generate and emit low RF energy. Such a microneedling device may comprise a drive motor, drive circuitry for controlling the drive motor, and a drive linkage located on the drive motor rotor. The microneedling device may also comprise a power source capsule comprising a battery and associated power management circuitry. Also included may be a needle cartridge coupled to the main body, and comprising a drive shaft and a needle unit coupled to a distal end of the drive shaft to move therewith, where the needle unit has at least one needle extending therefrom. The drive shaft may comprise a linkage member configured to engage the drive linkage of the drive motor, and be configured to be driven by the drive motor and thereby drive movement of the needle unit such that the at least one needle extends beyond and retracts within the distal end of the needle cartridge.

Abstract: A balun is enhanced with design features that extend the operational bandwidth of the balun allowing the balun to operate at lower frequencies. The design enhancements also suppress resonances that otherwise cause sudden power drops at a resonance frequency while a load is connected between the balun's differential outputs.

Abstract: This invention provides a polymer, which is preferably a polyether polymer. The polymer may be used in coating compositions. Containers and other articles comprising the polymer and methods of making such containers and other articles are also provided. The invention further provides compositions including the polymer (e.g., powder coatings), which have utility in a variety of coating end uses, including, for example, valve and pipe coatings.

Abstract: Intelligent voice response systems and methods may include one or more machine readable instructions stored in a memory that cause a processor to receive an automated input including at least two of the following: a vehicle metric of the vehicle, a driving score of a user of the vehicle, a driving time during a trip of the vehicle, a geographical location of the vehicle, an adverse weather event within a predetermined distance of the vehicle, a historical driving route of the vehicle, a predicted driving route of the vehicle within a first predetermined period of time, or a sound within a predetermined distance of the vehicle. An action may be generated and implemented and reception of an affirmative response from the user may be determined. An alert may be generated to the user based on the affirmative response.

Abstract: Compounds, compositions, and methods useful for treating a viral infection, such as human immunodeficiency virus (HIV) infection, are disclosed. In particular, 4?-thionucleoside analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.

Abstract: This relates to methods for measuring irregularities in a signal and corresponding devices. The devices can include a PPG sensor unit configured to detect multiple occurrences of a given event in the measured signal(s) over a sampling interval. In some instances, the device can register the occurrences of the events. In some examples, the device can include one or more motion sensors configured to detect whether the device is in a low-motion state. The device may delay initiating measurements when the device is not in a low-motion state to enhance measurement accuracy. Examples of the disclosure further include resetting the sample procedure based on one or more factors such as the number of non-qualifying measurements. In some examples, the device can be configured to perform both primary and secondary measurements, where the primary measurements can include readings using a set of operating conditions different from the secondary measurements.

Abstract: The present disclosure describes 4?-fluoromethyl nucleosides for treating viral infections, including Dengue.

Abstract: A method for associating dose related data captured with and stored in an add-on device to a drug delivery device by means of an external computing device is described. The method includes: providing a drug delivery device comprising identification information, providing an add-on device, comprising communication means allowing the add-on device to communicate with an external computing device, means for capturing and storing dose related data, wherein the add-on device is adapted to be releasably mounted on and in engagement with the drug delivery device, providing an external computing device comprising, means for receiving the identification information from the drug delivery device, communication means allowing the external control device to communicate with the add-on device, processor means, and storage means comprising a computer program.