Publication number: 20150291954
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.
Type:
Application
Filed:
January 8, 2013
Publication date:
October 15, 2015
Applicant:
NOVARTIS AG
Inventors:
Brian Richard Bettencourt, David Anton Bumcrot, Dieter Huesken, Satyanarayana Kuchimanchi, Stuart Milstein, Michael Ray Schlabach, JR., Frank Peter Stegmeier, Markus Warmuth, Jan Weiler
Publication number: 20150252922
Abstract: Apparatus and method for mechanically attached connections of conduits may include a conduit gripping member, a drive member, and a seal member, the drive member causing axial movement of the conduit gripping member to indent into an outer surface of the conduit when the assembly is pulled-up, the drive member causing the seal member to form a zero clearance seal at a location that is axially spaced from the conduit gripping member. The zero clearance seal may comprise a face seal arrangement including a gasket, and the conduit gripping member may be a ferrule, ring or other device that can grip and optionally seal against the conduit outer surface. The assembly may include a sensing function for detecting or sensing a characteristic or condition of an assembly component or the fluid or both. In one embodiment, a body coupling member has a two piece construction of a main body and a conduit socket insert. A flared fitting embodiment is also provided.
Type:
Application
Filed:
March 16, 2015
Publication date:
September 10, 2015
Inventors:
Arthur Frank Anton, Michael Ray Butkovic, Johan Jan Goemans, Kevin Mracek, Dale C. Arstein, Franziska H. Dacek, John D. Karkosiak, Jeffrey Michael Rubinski, David Bryan O'Connor, David E. O'Connor, Nicholas Raney Lubar, Gerhard H. Schiroky, Mark A. Bennett, Theodore J. Gausman, Andrew P. Marshall, Larry Dean Vandendriessche, Sylvia Antoinette Bon, William H. Glime, III, Michael Jerome Mohlenkamp, Peter C. Williams, Richard A. Ales, Steven W. Moore, Sunniva R. Collins