Patents by Inventor Michael Saunders
Michael Saunders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230088269Abstract: The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.Type: ApplicationFiled: August 11, 2022Publication date: March 23, 2023Inventors: Christophe Frederic Jerome BLANCHETOT, Birgitte URSØ, Tine SKAK-NIELSEN, Malene BERTELSEN, Sebastian VAN DER WONING, Michael SAUNDERS, Johannes Joseph Wilhelmus DE HAARD
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Publication number: 20230082391Abstract: A footwear article includes (a) an upper having a tongue opening at a front thereof; (b) a gusseted tongue including a tongue panel positioned over the tongue opening and a pair of gussets attaching laterally opposite sides of the tongue panel to the upper; (c) a pair of tongue fasteners configured to selectively fasten and unfasten corresponding sides of the tongue panel to and from the upper; (d) a first lacing system on the upper and arranged for guiding lacing over the gusseted tongue and tongue fasteners when the sides of the tongue are fastened to the upper; and (e) a second lacing system on the tongue panel and arranged for guiding the lacing across the tongue panel clear of the tongue fasteners when the sides of the tongue panel are unfastened from the upper.Type: ApplicationFiled: September 16, 2021Publication date: March 16, 2023Inventors: Christopher Anderson, Adam Meek, Oliver Saunders, Michael Edward Blackford
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Publication number: 20230029027Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant prenyltransferase enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to the wild type prenyltransferase. The disclosure also provides methods of preparing such recombinant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.Type: ApplicationFiled: April 13, 2020Publication date: January 26, 2023Inventors: Michael MENDEZ, Joseph NOEL, Michael BURKART, Jeremy LANOISELEE, Kyle BOTSCH, Matthew SAUNDERS
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Patent number: 11549730Abstract: A refrigerated food container system includes a container defining an inner volume and a thermoelectric module arranged in thermal contact with at least one surface of the container. The thermoelectric module includes a first thermoelectric cooling device and a second thermoelectric cooling device in thermal contact with the first thermoelectric cooling device. A control module is configured to provide a first voltage to the first thermoelectric cooling device and provide a second voltage to the second thermoelectric cooling device.Type: GrantFiled: January 31, 2020Date of Patent: January 10, 2023Assignee: Emerson Climate Technologies, Inc.Inventors: Jason A. Born, Damiel Faxon, Andrew Mangelsdorf, Michael A. Saunders
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Publication number: 20220411766Abstract: Described herein are prenyltransferases including non-natural variants thereof having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferases and that are capable of at least two-fold greater rate of formation of cannabinoids such as cannabigerolic acid, cannabigerovarinic acid, cannabigerorcinic acid, and cannabigerol, as compared to a wild type control. Prenyltransferase variants also accept different hydrophobic substrates (e.g., “donor” molecules), compared to wild type controls, to create different minor and novel cannabinoids. Prenyltransferase variants also demonstrated regioselectivity to desired cannabinoid isomers such as CBGA (3-GOLA), 3-GDVA, 3-GOSA, and CBG (2-GOL). The prenyltransferase variants can be used to form prenylated aromatic compounds, and can be expressed in an engineered microbe having a pathway to such compounds, which include 3-GOLA, 3-GDVA, 3-GOSA, and CBG.Type: ApplicationFiled: October 2, 2020Publication date: December 29, 2022Inventors: Michael J. MENDEZ, Kyle BOTSCH, Tasha ALTHEIDE, Matthew SAUNDERS
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Patent number: 11509339Abstract: A method of processing a radio frequency signal includes: receiving the radio frequency signal at an antenna of a receiver device; processing, by a radio frequency front-end device, the radio frequency signal; converting, by an analog-to-digital converter, the analog signal to a digital signal; receiving, by a neural network, the digital signal; and processing, by the neural network, the digital signal to produce an output.Type: GrantFiled: February 28, 2019Date of Patent: November 22, 2022Assignee: BOOZ ALLEN HAMILTON INC.Inventors: Michael Calabro, Mehrnaz Mortazavi, Wade Leonard, Zachary Rohde, Alex Saunders
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Publication number: 20220364066Abstract: Described herein are variant, novel cannabinoid synthases, nucleic acids encoding same, and various uses thereof. In one aspect, a variant cannabinoid synthase or an active fragment thereof is provided comprising a non-naturally occurring amino acid sequence relative to a wild-type cannabinoid synthase or an active fragment thereof which acts on a substrate to produce an altered amount of a cannabinoid relative to an amount of the cannabinoid produced by the wild-type cannabinoid synthase or active fragment thereof.Type: ApplicationFiled: October 22, 2020Publication date: November 17, 2022Inventors: Kyle BOTSCH, Craig BEHNKE, Karla GONZALEZ, Matthew SAUNDERS, Michael J. MENDEZ, Jeremy LANOISELEE
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Patent number: 11463832Abstract: A system and method of adjusting an audio output in one location so that its propagation into another location is reduced. As a first device in a first location generates sound, a second device in a second location detects the propagated sound. The first device then adjusts its output based on the detected sound.Type: GrantFiled: March 23, 2021Date of Patent: October 4, 2022Assignee: DOLBY LABORATORIES LICENSING CORPORATIONInventors: C. Phillip Brown, Michael Smithers, Remi Audfray, Patrick Saunders
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Patent number: 11460224Abstract: Systems and methods for purging lubricant from a first compressor to a second compressor are provided. A control module receives a lubricant purge command, shuts the second compressor to an OFF-mode while the first compressor remains in the ON-mode, restricts working fluid from an outlet of the second compressor from flowing into the first compressor and allows compressed working fluid discharged from an outlet of the first compressor to flow into the inlet of the second compressor such that lubricant in the second compressor flows into the first compressor.Type: GrantFiled: October 30, 2019Date of Patent: October 4, 2022Assignee: Emerson Climate Technologies, Inc.Inventors: Michael A. Saunders, Kory M. Place, James Scott Fraser, Natarajan Rajendran, Jason A. Born, Daniel J. Rice
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Patent number: 11453288Abstract: This disclosure details electrified vehicle drive systems equipped with electric machine integrated axle assemblies. An exemplary electrified vehicle drive system includes a leaf spring assembly and an axle assembly mounted to the leaf spring assembly. The axle assembly may include a cradle and an electric machine mounted within the cradle. Shocks and stabilizer bar assemblies may extend between the cradle and a vehicle frame of the electrified vehicle.Type: GrantFiled: November 27, 2019Date of Patent: September 27, 2022Assignee: FORD GLOBAL TECHNOLOGIES, LLCInventors: Sahil Nagpal, Steven Michael Cyr, Robert Howard Saunders, Jr.
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Patent number: 11447544Abstract: The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.Type: GrantFiled: October 23, 2019Date of Patent: September 20, 2022Assignee: argenx BVInventors: Christophe Frederic Jerome Blanchetot, Birgitte Ursø, Tine Skak-Nielsen, Malene Bertelsen, Sebastian Van Der Woning, Michael Saunders, Johannes Joseph Wilhelmus De Haard
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Publication number: 20220177604Abstract: The present invention relates to antibodies that bind to IgE and their use in the treatment of autoimmune diseases, particularly Bullous Pemphigoid (BP) and Chronic Spontaneous Urticaria (CSU). The anti-IgE antibodies comprise a variant Fc domain that binds to the Fc receptor FcRn with increased affinity relative to a wild-type Fc domain. The anti-IgE antibodies may comprise a variant Fc domain comprising the amino acids Y, T, E, K, F and Y at EU positions 252, 254, 256, 433, 434 and 436, respectively, wherein the variant Fc domain binds to human FcRn with increased affinity relative to a wild-type human IgG Fc domain.Type: ApplicationFiled: April 9, 2020Publication date: June 9, 2022Inventors: Michael SAUNDERS, Rene BIGIRIMANA, Christophe BLANCHETOT, Marijn CROMHEECKE, Conor MCGUIRE
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Patent number: 11261246Abstract: The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.Type: GrantFiled: October 23, 2019Date of Patent: March 1, 2022Assignee: argenx BVInventors: Christophe Frederic Jerome Blanchetot, Birgitte Ursø, Tine Skak-Nielsen, Malene Bertelsen, Sebastian Van Der Woning, Michael Saunders, Johannes Joseph Wilhelmus De Haard
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Publication number: 20220030001Abstract: A method of creating secure endpoints on a network includes registering by a node using a random selection algorithm to choose which server to register to; receiving by the node a property set ID of a property set that the node is a member of; and authorizing by the node using the property set ID to look up its authorization details in the property set. A method of creating secure endpoints on a secure network having at least one community of interest, includes registering by a node using a random selection algorithm to choose which server to register to; receiving by the node a property set ID of a property set that the node is a member of; and authorizing by the node through an authorization server using the property set ID to look up its authorization details in the property set; wherein the node and the authorization server are a member of the at least one community of interest.Type: ApplicationFiled: July 27, 2021Publication date: January 27, 2022Applicant: Unisys CorporationInventors: Jared Poetter, Michael C. Leap, Diane E. Schaefer, Michael J. Di Domenico, Philippe Jolly, Richard W. Phelps, Robert A. Johnson, Michael Saunders, Robert R. Buckwalter, Sarah K. lnforzato, Eugene J. Gretter, George Karian
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Publication number: 20220029996Abstract: A network model includes nodes, node property sets, authorization groups and authorization servers. The node property sets define how the nodes operate and authenticate. The nodes are member of the node property sets. The authorization groups are associated with the node property set. And, authorization servers are member of the authorization groups. In addition, a network model in a secure network environment has at least one community of interest. The network model includes at least one node being a member of a node property set that defines how the node operates and authenticates.Type: ApplicationFiled: July 27, 2021Publication date: January 27, 2022Applicant: Unisys CorporationInventors: Jared Poetter, Michael C. Leap, Diane E. Schaefer, Michael J. Di Domenico, Philippe Jolly, Richard W. Phelps, Robert A.` Johnson, Michael Saunders, Robert R. Buckwalter, Sarah K. Inforzato, Eugene J. Gretter, George Karian
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Publication number: 20220030032Abstract: A generic endpoint package includes a generic node configuration, which can be used by all nodes within a network, containing consolidated configuration information regardless of the operating system, the generic node configuration including: node property sets; common information containing rules to apply to nodes while in service mode and prior to authorization; and registration information directing the node to a pre-defined registration servers. A method of using a generic endpoint package includes deploying the generic endpoint package having a generic node configuration, which can be used by all nodes within a network, containing consolidated configuration information regardless of the operating system, the generic node configuration including: node property sets; common information containing rules to apply to nodes while in service mode and prior to authorization; and registration information directing the node to a pre-defined registration servers.Type: ApplicationFiled: July 27, 2021Publication date: January 27, 2022Applicant: Unisys CorporationInventors: Jared Poetter, Michael C. Leap, Diane E. Schaefer, Michael J. Di Domenico, Philippe Jolly, Richard W. Phelps, Robert A. Johnson, Michael Saunders, Robert R. Buckwalter, Sarah K. Inforzato, Eugene J. Gretter, George Karian
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Patent number: 11230603Abstract: The present invention relates to a protein binding to GARP in the presence of TGF-? and uses thereof.Type: GrantFiled: February 14, 2020Date of Patent: January 25, 2022Assignees: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD, UNIVERSITÉ CATHOLIQUE DE LOUVAIN, argenx BVBAInventors: Sophie Lucas, Pierre Coulie, Julia Cuende Villasur, Laure Dumoutier, Jean-Christophe Renauld, Sebastian van der Woning, Michael Saunders, Hans De Haard, Gitte De Boeck
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Publication number: 20210404685Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a refrigeration system of a building; a leak module configured to diagnose that a leak is present in the refrigeration system based on the amount of refrigerant; and at least one module configured to take at least one remedial action in response to the diagnosis that the leak is present in the refrigeration system.Type: ApplicationFiled: September 9, 2021Publication date: December 30, 2021Applicant: Emerson Climate Technologies, Inc.Inventors: Brian R. BUTLER, Stuart K. MORGAN, Hung PHAM, Winfield S. MORTER, Andrew M. WELCH, David A. ALFANO, Michael A. SAUNDERS
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Publication number: 20210381708Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a first portion of a refrigeration system within a building; and an isolation module configured to selectively open and close an isolation valve of the refrigeration system and to, via the isolation valve, maintain the amount of refrigerant within the first portion within the building below a predetermined amount of the refrigerant.Type: ApplicationFiled: July 28, 2020Publication date: December 9, 2021Applicant: Emerson Climate Technologies, Inc.Inventors: Brian R. BUTLER, Stuart K. MORGAN, Hung PHAM, Winfield S. MORTER, Andrew M. WELCH, David ALFANO, Michael A. SAUNDERS
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Publication number: 20210369753Abstract: Described, among other things, are dosage forms for administration to a subject, the dosage forms having at least six ingredients are selected are from the group consisting of clove powder, rutin, hesperidin, baicalin, sulforaphane, moringa leaf extract, rosmarinic acid, guava leaf extract, Panax notoginseng, EGCG, propolis, coriander extract, cardamom extract, cinnamaldehyde, chlorogenic acid, caper fruit, vescalagin, nutmeg extract, and naringenin. The dosage forms can serve as inhibitors of quorum sensing by infectious agents. The described combinations of selected natural products have the ability to inhibit quorum sensing. Quorum sensing is a means by which bacteria and viruses communicate with each other and induce virulence in the body. This combination of natural products is preferably included in nutraceutical formulations in order to promote human immune health.Type: ApplicationFiled: April 26, 2021Publication date: December 2, 2021Inventors: Daniel A. Gubler, Michael Saunders