Abstract: The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-?1, particularly a complex of human GARP and human TGF-?1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-? from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.

Abstract: Systems and methods for performing dynamic coefficient of performance calculations for refrigeration systems are provided. A controller calculates a weighted Carnot efficiency of a refrigeration case based on outdoor temperature data, refrigeration case temperature data, a case load of a refrigeration case, and a case defrost status of the refrigeration case. The controller calculates a weighted coefficient of performance based on based on a refrigerant type, the case load of the refrigeration case, the case defrost status of the refrigeration case, and at least one of the of the refrigeration case temperature data and pressure data. The controller calculates a system performance index (SPI) for the refrigeration case based on the weighted Carnot efficiency of the refrigeration case and weighted actual Carnot efficiency. The controller generates, in response to the SPI being below a threshold, an output indicating that the refrigeration case is operating below a threshold efficiency.

Abstract: The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

Abstract: A refrigeration system includes first and second compressors, a condenser, first and second refrigeration cases, and a system controller. The first and second compressors are fluidly connected to respective first and second suction and discharge lines. The second suction line is fluidly connected to the first discharge line. The condenser receives refrigerant from the second compressor. The first and second refrigeration cases operate within respective first and second temperature ranges, the first range being lower than the second range. The first case includes a first evaporator that receives refrigerant from the condenser and discharges refrigerant to the first suction line. The second case includes a second evaporator that receives refrigerant from the condenser and discharges refrigerant to the second suction line. The system controller identifies when maintenance is necessary based on a first discharge temperature of the refrigerant in the first discharge line.

Abstract: A refrigeration system includes first and second compressors and an oil separator. The oil separator includes an inlet for receiving refrigerant and oil from the first compressor, a refrigerant outlet, and an oil outlet. The oil separator separates the oil from the refrigerant. A portion of the oil separator below a horizontal plane intersecting the refrigerant outlet collects separated oil and has a volume equal to a first compressor oil supply. The first compressor oil supply is greater than or equal to 100% and less than or equal to 250% of a first compressor initial oil charge. The first compressor receives oil from the oil outlet when an amount of oil in the portion is less than or equal to the first compressor oil supply. The second compressor receives oil from the refrigerant outlet when the amount of oil in the portion is greater than the first compressor oil supply.

Abstract: A refrigeration system includes first and second compressors, a condenser, first and second evaporators, and a valve. The first compressor is fluidly connected to first suction and discharge lines. The second compressor is fluidly connected to second suction and discharge lines. The second suction line is fluidly connected to the first discharge line. The condenser receives refrigerant from the second compressor. The first evaporator receives refrigerant from the condenser and discharges refrigerant to the first suction line. The second evaporator receives refrigerant from the condenser and discharges refrigerant to the second suction line. The valve is disposed between the first evaporator and the first suction line. The first suction line receives refrigerant when the valve is in a first position. The second suction line receives refrigerant when the valve is in a second position. The first compressor is bypassed when the valve is in the second position.

Abstract: The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

Abstract: The invention provides a product combination or composition, and also multispecific antibodies comprising two or more antigen-binding sites (as antibodies or antigen binding fragments thereof), wherein two the antigen-binding bind to distinct non-overlapping epitopes of the human c-Met protein. The product combination or composition or multispecific antibody inhibits HGF-independent activation of the human c-Met receptor protein.

Abstract: Scroll compressor designs are provided to minimize vibration, sound, and noise transmission. The scroll compressor has a bearing housing, and orbiting and non-orbiting scroll members. The non-orbiting scroll member has a radially extending flanged portion with at least one aperture substantially aligned with the axially extending bore. At least one fastener is disposed within the aperture and the bore. A sound isolation member contacts at least one of the non-orbiting scroll member, the fastener, or the bearing housing, to reduce or eliminate noise transmission. The sound isolation member may be formed of a polymeric composite having an acoustic impedance value greater than the surrounding materials. The sound isolation member may be an annular washer, an O-ring, or a biasing member, by way of non-limiting example. In other variations, fluid passages are provided within the fastener and/or bearing housing to facilitate entry of lubricant oil to further dampen sound and noise.

Abstract: Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

Abstract: The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

Abstract: Scroll compressor designs are provided to minimize vibration, sound, and noise transmission. The scroll compressor has a bearing housing, and orbiting and non-orbiting scroll members. The non-orbiting scroll member has a radially extending flanged portion with at least one aperture substantially aligned with the axially extending bore. At least one fastener is disposed within the aperture and the bore. A sound isolation member contacts at least one of the non-orbiting scroll member, the fastener, or the bearing housing, to reduce or eliminate noise transmission. The sound isolation member may be formed of a polymeric composite having an acoustic impedance value greater than the surrounding materials. The sound isolation member may be an annular washer, an O-ring, or a biasing member, by way of non-limiting example. In other variations, fluid passages are provided within the fastener and/or bearing housing to facilitate entry of lubricant oil to further dampen sound and noise.

Abstract: The invention provides a product combination or composition, and also multispecific antibodies comprising two or more antigen-binding sites (as antibodies or antigen binding fragments thereof), wherein two the antigen-binding bind to distinct non-overlapping epitopes of the human c-Met protein. The product combination or composition or multispecific antibody inhibits HGF-independent activation of the human c-Met receptor protein.

Abstract: The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

Abstract: Systems and methods for guarding a controller area network are disclosed. In one embodiment, a system for guarding a controller area network comprises one or more processors. The one or more processors may be configured to receive a message destined for the controller area network. The one or more processors may further be configured to determine whether the message is legitimate. The one or more processors may further be configured to modify the message, if the message is determined as illegitimate, as an error message.

Abstract: The present invention relates to an antibody binding to the transmembrane protein ‘glycoprotein A repetitions predominant’ (GARP) in the presence of TGF-? and uses thereof.

Abstract: A fuel pump arrangement has multiple fuel pumps for fitting to aircraft fuel tanks and allowing maintenance of the pumps without requiring access from inside the tanks, particularly one having a housing with two fuel pumps for mounting in or adjacent a single aperture in the wall of a fuel tank, each pump being individually removable from the housing by withdrawal away from the tank. A sleeve is moveable also in the same direction as the pump to obstruct inlets in the housing and isolate the housing from the fuel in the tank so the tank need not be drained.

Abstract: The present invention relates to a protein binding to GARP in the presence of TGF-? and uses thereof.

Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: The present invention relates to antibodies and antigen binding fragments thereof derived from antibodies raised by DNA immunization of host animals, particularly camelids (e.g. llama). The antibodies and antigen binding fragments thereof bind to proteins which may be particularly large in size (at least 1115 amino acids in length), or have at least 8 transmembrane domains, or are naturally encoded by nucleotide sequences which are difficult to replicate in standard or common E. coli strains. The present invention also relates to antibodies and antigen binding fragments thereof which bind to ion channels, in particular the voltage-gated sodium channel Nav1.7. Methods of raising antibodies against particular protein targets by a process of DNA immunization are also provided.