Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: Provided are anti-syndecan-2 antibodies and compositions comprising said antibody and methods useful for treating acute respiratory distress syndrome, including coronavirus disease 2019-induced acute respiratory distress syndrome, in a subject in need thereof. The method comprises administering to the subject an effective amount to treat the acute respiratory distress syndrome of an syndecan-2 disrupting agent. The syndecan-2 disrupting agents may include at least one of the anti-syndecan-2 antibodies and/or at least one syndecan-2 disrupting peptide.

Abstract: Exemplary embodiments are directed to a system and method for continuous downlinking communication from a surface location to a bottom hole assembly during drilling operations. The system transmits harmonic pressure wave fluctuations generated by a modulator, which is disposed outside of a surface-located fluid line with a flap rotatably disposed entirely inside of the fluid line encoding data by harmonics. One letter of the combinatorial frequencies signal alphabet can have more than 200 different orthogonal frequencies components; each component represents a unique combination of downlinking command purpose and value. For deepest portion of a long trajectory well, the system uses a narrow frequency range (2-3 Hz) with two letters resulting in more than 250 combinations. The system provides continuous automatic downhole control of the signal-to-noise ratio to achieve robust decoding of downlinking signals with a transmission data rate ten times faster as compared to 1-2 bits per minute in the industry.

Abstract: Embodiments of the present disclosure relate to methods of finding optimized analog measurement hardware settings of a measurement system for a target measurement. The method can include one or more of the following steps: applying initial settings to the measurement system; varying the settings over a power sweep while processing a test signal used for the target measurement or a representative signal; performing the target measurement during the power sweep, thereby determining a hardware contribution of the measurement system over the power sweep; and identifying the respective settings that lead to a minimum hardware contribution of the measurement system at various powers.

Abstract: Apparatuses and methods are provided for generating one or more images using an example apparatus. An example apparatus includes a plurality of pixel elements fabricated on two or more substrates, wherein each pixel element comprises a plurality of compound refractive lenses. Each compound refractive lens comprises a plurality of concave lenses and each compound refractive lens defines a proximal end and distal end. Each pixel element further comprises a plurality of photon counting detectors, wherein each photon counting detector is configured to receive a beam exiting from the distal end of a particular compound refractive lens.

Abstract: A method for managing an automation system involving asynchronous and synchronous zones, the method including: determining when a moving element enters a merge zone between an asynchronous zone and a synchronous zone; calculating additive jerk to be applied to the moving element, In some cases, the additive jerk is based on predetermined compensation profiles; determining if the master position change is different than a base logged; if so, interpolating additive jerk based on movement characteristics of the moving element; in either event, applying the additive jerk to the moving element; and determining if the merge is completed and, if yes, ending the merge and continue with synchronous operation but, if no, returning to calculating the additive jerk and repeat. A system including a processor/controller and a memory including instructions, which when executed by the processor/controller, perform the method.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: This disclosure relates generally to using machine learning models to generate current time-series features using machine learning and validate time-series machine learning model output. At least one aspect is directed to a system with one or more processors, coupled to memory, to segment a time series range into a first segment for an instance of time, the segment associated with a value for a target feature and a timestamp for the value, segment the time series range into an input segment associated with a plurality of input features and a segment timestamp less than or equal to the timestamp, generate a model trained with input comprising values for the target feature and timestamps for the values less than or equal to the segment timestamp, and transform at least one of the input features based at least on the model.

Abstract: In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that increases the activity or level of a let-7 miRNA or an agent that decreases activity or level of a TGF? signaling polypeptide in an endothelial cell in the subject. In some embodiments, the subject is administered an additional agent comprising a therapeutically effective amount of rapamycin or any derivative thereof. In some embodiments, the agent is a let-7 miRNA. In some other aspects, the invention provides a pharmaceutical composition comprising a let-7 miRNA. In some embodiments, the let-7 miRNA is encapsulated in a nanoparticle formulated for selective delivery to an endothelial cell.

Abstract: A device that confines a water soluble larvicide or insecticide or other solid or semi-solid chemical medium that allows for a measured dispersal with a means for affixing to a rain gutter or open water container susceptible to harbor or breed mosquito larvae.

Abstract: A combinatorial frequency system and method for transmitting data from LWD downhole operations to a surface location is provided. The system and method include obtaining data from at least one downhole sensor, encoding data by combinations of different harmonics, and (optionally) modulating the data using various frequency modulation techniques to produce a series of 3-40 bit rates. The system and method include transmitting the series as pressure wave signals through drilling fluid or through earth media by electromagnetic waves, detecting the signals, identifying at a surface location each frequency, modulating characteristics of each frequency, decoding each signal and forming output signals.

Abstract: The disclosure relates to a regulating device for regulating the steering angle for a vehicle, comprising a first controller unit with a controller superposed thereon, the controller having a feedback path and a prefilter. The feedback path provides a first adjustment variable based on actual steering angle information which is provided by the first controller unit as an output variable and the prefilter provides a second adjustment variable based on nominal steering angle information. The controller is configured to form input information for the first controller unit based on the first and the second adjustment variables, wherein the feedback path has a first correction element, the transfer behavior of which can be adjusted. The prefilter has a second correction element, the transfer behavior of which can be adjusted. The controller is configured such that at least the controller gain of the first controller unit can be adjusted.

Abstract: A railborne driver assistance device for supporting or automating the lateral control of a vehicle includes a first processing unit configured to control a steering torque intervention by establishing a steering angle with a stationary control accuracy of an electrically supported steering system. A second processing unit is configured to adjust the stationary control accuracy of the steering angle via the output of an accuracy request signal to the first processing unit in such a way that there is a scaling of the control accuracy between a lower and an upper threshold value. The second processing unit includes a control unit having an integrator with an input and an output, wherein the output of the integrator is connected to the input in a closed-loop manner with a weighting dependent on the accuracy request signal.

Abstract: A regulating device for regulating the steering angle of a vehicle includes a first controller unit having at least one integrating component and configured to receive a control difference between first steering angle information, which is deduced from nominal steering angle information, and an actual steering angle. The first controller unit provides actuation information for a motor operating the steering. A compensation control circuit superposed on the first controller unit is provided. The compensation control circuit has a feedback path receives actuation information of the motor, the output torque of the motor, and/or information dependent on the output torque of the motor as the input variable and, based on the input variable, provides steering angle compensation information.

Abstract: In various aspects and embodiments, the invention provides methods of treating pulmonary arterial hypertension by inhibiting the endothelial to mesenchymal transition. The invention provides a method of treating pulmonary arterial hypertension (PAH) in a subject, the method comprising administering to the subject an agent that modulates the activity or level of let-7 mlRNA in an endothelial cell in the subject, thereby treating PAH in the subject. In another aspect, the invention provide a method of treating PAH in a subject, the method comprising administering to the subject an agent that decreases the activity or level of an endothelial TGF? signaling polypeptide or a TGF? peptide receptor, thereby treating PAH in the subject.

Abstract: In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that increases the activity or level of a let-7 miRNA or an agent that decreases activity or level of a TGF? signaling polypeptide in an endothelial cell in the subject. In some embodiments, the subject is administered an additional agent comprising a therapeutically effective amount of rapamycin or any derivative thereof. In some embodiments, the agent is a let-7 miRNA. In some other aspects, the invention provides a pharmaceutical composition comprising a let-7 miRNA. In some embodiments, the let-7 miRNA is encapsulated in a nanoparticle formulated for selective delivery to an endothelial cell.

Abstract: An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

Abstract: A combinatorial frequency system and method for transmitting data from LWD downhole operations to a surface location is provided. The system and method include obtaining data from at least one downhole sensor, encoding data by combinations of different harmonics, and (optionally) modulating the data using various frequency modulation techniques to produce a series of 3-40 bit rates. The system and method include transmitting the series as pressure wave signals through drilling fluid or through earth media by electromagnetic waves, detecting the signals, identifying at a surface location each frequency, modulating characteristics of each frequency, decoding each signal and forming output signals.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: A syringe accessory device which provides ergonomic advantage by allowing use of adductive thumb and finger force during aspiration, comprising a unitary structure, and configured for ease of attachment to a typical syringe. The accessory is comprised of three main sub-structures, contiguously formed, namely a plunger flange attachment, a syringe barrel attachment, and a linking element between the two attachments.