Abstract: A method of detecting and mitigating Global Navigation Satellite System (GNSS) spoofing events may comprise determining a first vehicle state based on an Inertial Navigation System (INS) without GNSS input, determining a second vehicle state based on an INS with GNSS input, and comparing the first vehicle states. When a difference between the vehicle states exceeds a predetermined threshold, the method concludes that GNSS spoofing is present, and utilizes only the first vehicle state as a correct vehicle state. The method may further implement at least one state processing path, comprising consecutive processing runs based on INS sensors. The method may further comprise reevaluating the vehicle state processing path, when the difference between the first vehicle state and the second vehicle state exceeds a threshold, to extricate a GNSS component from the processing path to at least a predetermined amount of time prior to when the GNSS spoofing was detected.

Abstract: A measurement device with automatic optimization capabilities comprises at least one signal processing component with a physical detector and a virtual detector component comprising at least one virtual detector for a signal processing component without physical detector. The physical detector is configured to physically measure a measurement value assigned to the signal processing component. The virtual detector component is configured to use a model of a signal processing chain from the physical detector to the location of the virtual detector. The model comprises at least one model parameter for the signal processing chain. The measurement device is configured to adapt the virtual detector component with respect to a measurement type for the signal to be measured. The virtual detector component is configured to use the model and the at least one measurement value.

Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: Described herein is a system and method for displaying annotation(s) of an electronic document. User input to review (e.g., scroll) the electronic document is received, until a selected portion of the electronic document is displayed within a viewport pane of a display. In response to the review input, annotation(s) (e.g., comment(s), comment thread(s), annotation thread(s)) anchored within the selected portion of the electronic document displayed within the viewport pane are identified. Which annotation of the annotation(s) to visually distinguish for a focus of the user is determined. The identified annotation(s) are displayed in an annotation pane, with the determined annotation visually distinguished (highlighted) for the focus of the user. In some embodiments, the anchor associated with the determined annotation is also visually distinguished to provide a contextual link to the user and/or hint(s) that provided a visual signal of annotation(s) associated with an anchor on a particular line are displayed.

Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of diseases related to vascular permeability. In another aspect, the invention provides a method of treating a vascular permeability related disease in a subject, the method comprising administering to the subject an effective amount of a syndecan-2 disrupting agent.

Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: A method of detecting and mitigating Global Navigation Satellite System (GNSS) spoofing events may comprise determining a first vehicle state based on an Inertial Navigation System (INS) without GNSS input, determining a second vehicle state based on an INS with GNSS input, and comparing the first vehicle states. When a difference between the vehicle states exceeds a predetermined threshold, the method concludes that GNSS spoofing is present, and utilizes only the first vehicle state as a correct vehicle state. The method may further implement at least one state processing path, comprising consecutive processing runs based on INS sensors. The method may further comprise reevaluating the vehicle state processing path, when the difference between the first vehicle state and the second vehicle state exceeds a threshold, to extricate a GNSS component from the processing path to at least a predetermined amount of time prior to when the GNSS spoofing was detected.

Abstract: A method of generating a clinically supplemented risk score using data from an electronic health record system can include collecting data from a plurality of electronic health records; parsing the data into defined fields; comparing the parsed data to at least one look-up table to generate an inferred diagnostic condition; comparing the inferred diagnostic condition to a documented diagnostic condition; mapping the inferred diagnostic condition to at least one condition category; refining the at least one mapped inferred diagnostic condition into a hierarchy to generate a hierarchal mapped conditioned category; and determining via a processor, a risk score in response to the inferred diagnostic condition for the patient in response to the hierarchal mapped conditioned category, the risk score representing an expected total cost of care for the patient relative to the average per-patient cost of care over an entire population.

Abstract: A measurement device with automatic optimization capabilities comprises at least one signal processing component with a physical detector and a virtual detector component comprising at least one virtual detector for a signal processing component without physical detector. The physical detector is configured to physically measure a measurement value assigned to the signal processing component. The virtual detector component is configured to use a model of a signal processing chain from the physical detector to the location of the virtual detector. The model comprises at least one model parameter for the signal processing chain. The measurement device is configured to adapt the virtual detector component with respect to a measurement type for the signal to be measured. The virtual detector component is configured to use the model and the at least one measurement value.

Abstract: A method of generating a clinically supplemented risk score using data from an electronic health record system can include collecting data from a plurality of electronic health records; parsing the data into defined fields; comparing the parsed data to at least one look-up table to generate an inferred diagnostic condition; comparing the inferred diagnostic condition to a documented diagnostic condition; mapping the inferred diagnostic condition to at least one condition category; refining the at least one mapped inferred diagnostic condition into a hierarchy to generate a hierarchal mapped conditioned category; and determining via a processor, a risk score in response to the inferred diagnostic condition for the patient in response to the hierarchal mapped conditioned category, the risk score representing an expected total cost of care for the patient relative to the average per-patient cost of care over an entire population.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: A document accessible on a network may be opened by multiple users. A user may use a thin client application to access the document, wherein an image of the document and XML data including comments and locations of the comments in the document. Hint icons are displayed in the document where comments are anchored. Upon selection of a hint, an HTML comments pane may be displayed to a side of the document, exposing comments and replies to comments currently stored in the document. The comments pane may be scrolled to the comment associated with the selected hint. Additionally, highlighting may be provided over elements in the document associated with a selected comment. Comments may be added via the comments pane and saved to the document on the network. Comments and comment location data may be communicated to other clients, allowing for collaborative communication via a thin client application.

Abstract: Described herein is a system and method for displaying annotation(s) of an electronic document. User input to review (e.g., scroll) the electronic document is received, until a selected portion of the electronic document is displayed within a viewport pane of a display. In response to the review input, annotation(s) (e.g., comment(s), comment thread(s), annotation thread(s)) anchored within the selected portion of the electronic document displayed within the viewport pane are identified. Which annotation of the annotation(s) to visually distinguish for a focus of the user is determined. The identified annotation(s) are displayed in an annotation pane, with the determined annotation visually distinguished (highlighted) for the focus of the user. In some embodiments, the anchor associated with the determined annotation is also visually distinguished to provide a contextual link to the user and/or hint(s) that provided a visual signal of annotation(s) associated with an anchor on a particular line are displayed.

Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: The invention relates to compositions and methods for reducing excessive vascular development and treat related disorders. In one aspect, the invention provides methods for treating, reducing or inhibiting vascular development in a subject in need thereof. The methods of the invention comprises administering to the subject an effective amount of a HK2 depleting agent that decreases the level of expression and/or activity of HK2. In some embodiments, the level of expression and/or activity of fibroblast growth factor receptor (FGFR), FGF ligand and/or FGF signaling is/are decreased. The invention also includes methods for diagnosing excessive vascular development and for measuring the efficacy of a treatment for an excessive vascular development in a subject in need thereof. The invention further includes a pharmaceutical composition for treating or reducing angiogenesis or lymphangiogenesis, comprising a HK2 depleting agent and a pharmaceutical acceptable carrier.

Abstract: A method of detecting and mitigating Global Navigation Satellite System (GNSS) spoofing events may comprise determining a first vehicle state based on an Inertial Navigation System (INS) without GNSS input, determining a second vehicle state based on an INS with GNSS input, and comparing the first vehicle states. When a difference between the vehicle states exceeds a predetermined threshold, the method concludes that GNSS spoofing is present, and utilizes only the first vehicle state as a correct vehicle state. The method may further implement at least one state processing path, comprising consecutive processing runs based on INS sensors. The method may further comprise reevaluating the vehicle state processing path, when the difference between the first vehicle state and the second vehicle state exceeds a threshold, to extricate a GNSS component from the processing path to at least a predetermined amount of time prior to when the GNSS spoofing was detected.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.