Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: A measuring device for measuring a signal with a first component signal and at least one second component signal comprises a high-frequency processing device, which is embodied to mix the signal in order to form an intermediate-frequency signal and to digitize the latter in order to form a digital composite signal. The measuring device further comprises a digital mixer, which is embodied to generate a first digital composite test signal and a second digital composite test signal subject to a displacement of the frequency of the digital composite signal. Moreover, the measuring device comprises a digital filter, which is embodied to filter the first digital composite test signal in order to form a first digital test signal and to filter the second digital composite test signal in order to form a second digital test signal.

Abstract: Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGF? inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed.

Abstract: Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGF? inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed.

Abstract: An improved device and system for power transmission. A power transmission device comprises a primary winding magnetically coupled to a resonant secondary which comprises a plurality of magnetic resonators, each magnetic resonator comprising a magnetic winding. The magnetic resonators are connected in series and arranged so that the magnetic axis of each magnetic resonator is coupled to the primary winding. In operation, a power source supplies alternating current at an operating frequency to the primary of a power transmission device used as a transmitter. A load is coupled to the primary of a power transmission device used as a receiver. Collectors may be coupled to either or both of the transmit or receive device. A return line may be coupled to either or both of the transmit or receive device.

Abstract: The invention relates to a carriage cart, which comprises a chassis frame with a front end and a rear end; a pair of front wheels mounted on the front end of the chassis frame; a pair of rear wheels mounted on the rear end of the chassis frame. The carriage cart according to example embodiments of the present invention may improve the performance of obstacle overcoming for robotic system.

Abstract: The invention relates to a device which includes two longitudinal deflecting surfaces or two pluralities of longitudinal deflecting surfaces, which are symmetrical on either side of the plane formed by the roll and yaw axes of the device and substantially in line with the roll axis and parallel to same, an air flow generator including at least one axial fan suctioning ambient air by means of at least one propeller faired in a flow path and, downstream of said propeller, an air distributor-diffuser, consisting of two adjacent semi-distributors each defining a curved duct directing the air to an outlet opening and toward the longitudinal deflecting surface or plurality of longitudinal deflecting surfaces.

Abstract: Systems, methods and computer-readable media are provided for enabling and/or managing contribution of paid time off. A system including one or more units configured for determining the value of paid time off as currency; and one or more units configured for conducting a transaction wherein paid time off is designated for contribution, and the determined value of the paid time off is designated for payment to one or more organizations is provided. Corresponding methods and computer-readable media are also provided.

Abstract: An electronic health record system includes a query translation engine in communication with a user interaction module to transform query phrases from the user interaction module into formalized database queries of the extracted data from a data organization module.

Abstract: A method of generating a clinically supplemented risk score using data from an electronic health record system can include collecting data from a plurality of electronic health records; parsing the data into defined fields; comparing the parsed data to at least one look-up table to generate an inferred diagnostic condition; comparing the inferred diagnostic condition to a documented diagnostic condition; mapping the inferred diagnostic condition to at least one condition category; refining the at least one mapped inferred diagnostic condition into a hierarchy to generate a hierarchal mapped conditioned category; and determining via a processor, a risk score in response to the inferred diagnostic condition for the patient in response to the hierarchal mapped conditioned category, the risk score representing an expected total cost of care for the patient relative to the average per-patient cost of care over an entire population.

Abstract: A document accessible on a network may be opened by multiple users. A user may use a thin client application to access the document, wherein an image of the document and XML data including comments and locations of the comments in the document. Hint icons are displayed in the document where comments are anchored. Upon selection of a hint, an HTML comments pane may be displayed to a side of the document, exposing comments and replies to comments currently stored in the document. The comments pane may be scrolled to the comment associated with the selected hint. Additionally, highlighting may be provided over elements in the document associated with a selected comment. Comments may be added via the comments pane and saved to the document on the network. Comments and comment location data may be communicated to other clients, allowing for collaborative communication via a thin client application.

Abstract: Aspects of the present disclosure are directed to methods and systems dynamic trust federation. In one aspect, a computer implemented method may include a security token that enables sign-on into a group applications based on applicable trust criteria. In one aspect, when a user interacts with one application in the group, the trust is elevated through the application internal authentication application program interface (API). The trust may be included in the security token to make available to other applications in the group. Applications can be in multiple groups with variable level of authentication based on location and other transactions variables.

Abstract: A document accessible on a network may be opened by multiple users. A user may use a thin client application to access the document, wherein an image of the document and XML data including comments and locations of the comments in the document. Hint icons are displayed in the document where comments are anchored. Upon selection of a hint, an HTML comments pane may be displayed to a side of the document, exposing comments and replies to comments currently stored in the document. The comments pane may be scrolled to the comment associated with the selected hint. Additionally, highlighting may be provided over elements in the document associated with a selected comment. Comments may be added via the comments pane and saved to the document on the network. Comments and comment location data may be communicated to other clients, allowing for collaborative communication via a thin client application.

Abstract: A measuring device for measuring a signal with a first component signal and at least one second component signal comprises a high-frequency processing device, which is embodied to mix the signal in order to form an intermediate-frequency signal and to digitize the latter in order to form a digital composite signal. The measuring device further comprises a digital mixer, which is embodied to generate a first digital composite test signal and a second digital composite test signal subject to a displacement of the frequency of the digital composite signal. Moreover, the measuring device comprises a digital filter, which is embodied to filter the first digital composite test signal in order to form a first digital test signal and to filter the second digital composite test signal in order to form a second digital test signal.

Abstract: Aspects of the present disclosure are directed to methods and systems dynamic trust federation. In one aspect, a computer implemented method may include a security token that enables sign-on into a group applications based on applicable trust criteria. In one aspect, when a user interacts with one application in the group, the trust is elevated through the application internal authentication application program interface (API). The trust may be included in the security token to make available to other applications in the group. Applications can be in multiple groups with variable level of authentication based on location and other transactions variables.

Abstract: A universal broadband broadcasting service is provided. A spectrum-sharing database stores attributes associated with a shared spectrum, a policy controller controls access to the shared spectrum by broadcast service entities, and a gateway receives IP multicast traffic from the broadcast service entities and communicates the IP multicast traffic to a broadcast single frequency network.

Abstract: A method for improving the data rate of data for M/H receivers and for improving the quality of channel estimation in an ATSC-M/H transport data stream marks the transport data packets determined for the transmission of data for M/H receivers in N (e.g., 38) consecutively transmitted transport data packets in an ATSC-M/H-slot of the uncoded ATSC-M/H transport data stream originally determined for the transmission of data for stationary receivers. Coded data for M/H receivers are inserted in the marked transport data packets and introduce training sequences in segments of data fields of the coded ATSC-M/H transport data stream containing marked transport data packets.

Abstract: An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

Abstract: A powertrain assembly includes an internal combustion engine, a boost mechanism and a fluid supply mechanism. The boost mechanism is in communication with an air source and the internal combustion engine. The fluid supply mechanism includes a first accumulator in communication with a pressurized fluid supply from the internal combustion engine and the boost mechanism. The accumulator receives pressurized fluid from the internal combustion engine during engine operation and provides the pressurized fluid to the boost mechanism during an engine off condition.