Abstract: The present invention provides both a method and means for regulating I?B? degradation, NF?B activity, and NF?B-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such I?B? and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with I?B? is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of I?B?, a decrease of NF?B activity, and a down-regulation of NF?B-dependent expression.

Abstract: The present invention provides both a method and means for regulating I?B? degradation, NF?B activity, and NF?B-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such I?B? and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with I?B? is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of I?B?, a decrease of NF?B activity, and a down-regulation of NF?B-dependent gene expression.

Abstract: Systems, methods, apparatus and computer program products are provided for signaling a deterministic mapping corresponding to a service. The deterministic mapping is inserted within an in-band ATSC vestigial sideband broadcast signal or an out-of-band signal and transmitted to receivers capable of consuming the service.

Abstract: Systems, methods, apparatus are provided for providing to a receiver a time diverse digital signal corresponding to a service including receiving a digital signal containing a service content and receiving a digital signal containing a non-deterministic content. The service content is inserted into a first predetermined number of data packets in a first predetermined number of data frames deterministically. In addition, a first portion of the non-deterministic content is inserted into a second predetermined number of data packets in the first predetermined number of data frames. A copy of the first predetermined number of data packets is generated. The first predetermined number of data frames is broadcast over a distribution network. The copy of the first predetermined number of data packets is inserted into a second predetermined number of data frames and a second portion of the non-deterministic content is inserted into the second predetermined number of data frames.

Abstract: A system, method, apparatus and computer code for communicating a training sequence for initializing an equalizer in a digital receiver are provided including receiving a digital signal containing data to be broadcast from a digital RF transmitter and inserting the training sequence into the digital signal deterministically such that a predetermined sequence of symbols are communicated to the receiver.

Abstract: Systems, methods, apparatus and computer program products are provided for signaling to a receiver an availability of a service and a deterministic mapping of a service content corresponding to the service. A modulator receives a digital signal and generates a data frame from the digital signal, where the data frame is divided into segments, where at least one grouping of the segments contains the service content. The modulator modulates at least one grouping in accordance with the deterministic mapping. A receiving device receives a digital signal containing the availability of a service, the deterministic mapping corresponding to the service, and the service content, and performs an operation on the service content in accordance with the deterministic mapping.

Abstract: A system, method, apparatus and computer code are provided for producing coherent symbols from digital RF transmitters. A multiplexer receives a digital signal containing content data to be broadcast from the digital RF transmitters and inserts a first initialization packet into the digital signal, where the initialization packets implicit position in the digital signal will signal data framing in the digital RF transmitters. Where the initialization packet contains stuff bytes for deterministically initializing Trellis coders in the digital RF transmitters. A transport stream emitter transmits the digital signal to the plurality of digital RF transmitters.

Abstract: A method for preventing disablement of a device includes assigning a contract identification code, receiving a loan payment, forwarding the loan payment from a payment center to a finance company having an interest in the device, a code delivery computer determining whether the finance company has received the payment, the code delivery computer determining a previous code released for the device, releasing a new code subsequent to the previous code released for the device if the code delivery computer determines that the finance company has received the payment, the code delivery computer receiving the associated contract identification code from a user via telephony or an internet link, the code delivery computer providing the new code directly to the user via telephony, an internet link, or an email, and the device receiving the code from the user, thereby preventing disablement of the device.

Abstract: An exemplary appliance control system for controlling an appliance includes a controller located inside the appliance, wherein the controller comprises a switch arranged between the electric power source and the appliance power supply and a receiver, a payment control center, and a payment control module comprising a transmitter for communicating with the controller receiver and a modem for communicating with the payment control center via a communication network. Another exemplary appliance control system includes a switch located between an electrical power source and an electrical power socket that provides electrical power to the appliance, a payment control center, and a payment control module that communicates with the switch and the payment control center, wherein the payment control module instructs the switch to open when the payment control center indicates that a finance payment for the appliance is past due.

Abstract: The present invention relates to a method of detecting collateral artery formation by measuring the level of NT-pro-BNP or BNP in an individual.

Abstract: The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having separate and individual DNA sequenced portions coding for an heparan sulfate binding extracellular domain, a central transmembrane domain, and a cytoplasmic domain coding for the syndecan-4 polypeptide. The prepared DNA sequence unitary fragment may be delivered to endothelial cells in-situ, both under in-vivo and/or in-vitro conditions, using suitable expression vectors including plasmids and viruses. The resulting transfected endothelial cells overexpress heparan sulfate binding, core proteins; and the resulting overexpression of these proteoglycan entities causes stimulation of angiogenesis in-situ.

Abstract: A composition and method are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by the internalization of a target cell specific ligand bonded to a RNA binding protein to which a double-stranded RNA containing a small interfering RNA nucleotide sequence is adsorbed. The ligand is specific to a unique target cell surface antigen. The ligand is either spontaneously internalized after binding to the cell surface antigen.

Abstract: A composition and method are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by the internalization of a target cell specific ligand to which the double-stranded RNA containing a small interfering RNA nucleotide sequence is conjugated. The ligand is specific to a unique target cell surface antigen. The ligand is either spontaneously internalized after binding to the cell surface antigen. Internalization is also facilitated by the binding of an RNA binding protein to the double-stranded RNA.

Abstract: Double-stranded DNA which encodes for a promoter region and for small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by the internalization of a target cell specific ligand bonded to the double-stranded DNA which encodes for a promoter region and for a small interfering RNA nucleotide sequence. The ligand is spontaneously internalized after binding to the cell surface antigen. Optionally, internalization is also facilitated by the binding of a DNA binding protein to the double-stranded DNA. If the unique cell surface antigen is not naturally internalized after binding to its ligand, internalization is promoted by the incorporation of an internalization moiety into the structure of the ligand or attachment of such a peptide to the ligand.

Abstract: The invention relates to a method for the preparation of a printing plate comprises forming an oleophilic image on a substrate for a printing plate comprising a support having at least one hydrophilic layer on its surface, the oleophilic image being formed by inkjet printing an aqueous solution or aqueous colloidal dispersion of an anionic oleophilising agent on the surface of the support and drying the applied solution or dispersion, such that, on drying, the area of the surface to which the solution or dispersion was applied becomes lithographic ink-accepting, characterised in that the hydrophilic layer comprises a crosslinked cationic polymer. The invention further relates to a substrate for a printing plate comprising a support having at least one hydrophilic layer on its surface wherein the hydrophilic layer comprises a crosslinked cationic polymer.

Abstract: A user interface for a vehicle disablement system is provided. The user interface provides an indication of an amount of time remaining prior to disablement of the vehicle. The indication can be performed using a light emitting diode (LED) which produces either a red or green light. The indication can also be performed by an LED producing a number of blinks corresponding to the amount of time remaining prior to disablement of the vehicle. Additional LEDs can be provided within a numbered user interface, for example, wherein an LED of a number on the user interface is illuminated corresponding to an amount of time remaining prior to disablement of the vehicle.

Abstract: A vehicle disablement device detects whether it has been tampered with. If the vehicle disablement device determines that it has been tampered with, the vehicle disablement device sends a signal to a tamper disabler. The tamper disabler is then able to disable the vehicle in the same manner in which the vehicle disablement device disables the vehicle. Accordingly, the vehicle may be disabled even when the vehicle disablement device is tampered with.

Abstract: A real time apparatus for testing a DTV antenna transmitting system, wherein the DTV antenna transmitting system transmits an original signal from a DTV transmitter to a DTV transmitting antenna, is disclosed that includes a probe, wherein the probe is connected in series with the DTV antenna transmitting system, and senses signals traversing the DTV antenna transmitting system. An error detector of the testing apparatus compares the received signal to the original signal to identify the magnitude and location of errors.

Abstract: A vehicle disablement device disables a vehicle if it a payment has not been received prior to a payment due deadline. The vehicle can also be disabled if it is determined that the vehicle disablement device is being tampered with. Disablement of the vehicle occurs by transmission of a wireless signal from a vehicle disablement device to a relay in a power control panel. The disablement can also occur by transmission of a second wireless signal from a tamper disabler (or a tamper receiver) to a relay in the power control panel. The critical system of the vehicle that can be disabled by the vehicle disablement device can be the same or a different critical system as that which can be disabled by the tamper disabler (or a tamper receiver).

Abstract: The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having separate and individual DNA sequenced portions coding for an heparan sulfate binding extracellular domain, a central transmembrane domain, and a cytoplasmic domain coding for the syndecan-4 polypeptide. The prepared DNA sequence unitary fragment may be delivered to endothelial cells in-situ, both under in-vivo and/or in-vitro conditions, using suitable expression vectors including plasmids and viruses. The resulting transfected endothelial cells overexpress heparan sulfate binding, core proteins; and the resulting overexpression of these proteoglycan entities causes stimulation of angiogenesis in-situ.