Abstract: A system and method for encapsulating a target application are described herein. In particular, an analysis of the target application can be performed to determine one or more characteristics of the target application. Based on the analysis of the target application, a blueprint of the target application can be generated. Based on the blueprint, an encapsulation application can be constructed for the target application. In addition, the target application can be encapsulated with the encapsulation application to create an encapsulated target application to enable adaptive loading of the target application.

Abstract: A target marking system includes a light source configured to emit a beam of thermal radiation and to impinge the beam onto a target. The system also includes a detector configured to collect radiation passing from the target to the detector along a path. The radiation passing from the target in response to impingement of the beam onto the target. The system further includes an optics assembly disposed optically upstream of the detector along the path. The optics assembly includes at least one of an afocal power changer, a camera objective, a catadioptric lens, and a zoom system configured to condition the radiation passing from the target to the detector.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: A target marking system includes a light source configured to emit a beam of thermal radiation and to impinge the beam onto a target. The system also includes a detector configured to collect radiation passing from the target to the detector along a path. The radiation passing from the target in response to impingement of the beam onto the target. The system further includes an optics assembly disposed optically upstream of the detector along the path. The optics assembly includes at least one of an afocal power changer, a camera objective, a catadioptric lens, and a zoom system configured to condition the radiation passing from the target to the detector.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: A method for generating a secure application is described herein. The method can include the steps of obtaining a target application and decomposing the target application into original files that contain predictable instructions. One or more predictable instructions in the original files may be identified. In addition, the target application may be modified to create the secure application by binding one or more intercepts to the target application. These intercepts can enable the modification of the predictable instructions in accordance with one or more policies such that the behavior of the secure application is different from the original behavior of the target application. Modification of the target application may be conducted without access to the source code of the target application.

Abstract: A method of enabling the federation of unrelated applications is described herein. The method can include the step of installing a candidate application for inclusion in a secure workspace. A first previously-installed application may have a certificate signed by a first entity, and a second previously-installed application may have a certificate signed by a second entity such that the first and second previously-installed applications have different certificates. The method can also include the steps of generating a federation value for the candidate application for inclusion in the secure workspace and determining the result of a federation check of the candidate application based on the generated federation value. If the federation check for the candidate application is satisfied, the candidate application may be permitted to be part of the secure workspace.

Abstract: A method and system of enabling communications among unrelated applications is described herein. The method includes the step of identifying a paste memory element in an environment of a computing device that restricts communications among unrelated applications. The method also includes the step of imposing a file system on the identified paste memory element. The file system is compatible with the unrelated applications such that a first unrelated application is capable of storing data in the paste memory element using the imposed file system and a second unrelated application is capable of accessing the stored data using the imposed file system. As an example, the first and second unrelated applications may be secure applications. In addition, the method can also include the steps of encrypting the data stored in the paste memory element that is associated with the first unrelated application and decrypting this data on behalf of the second unrelated application.

Abstract: A method and system of restricting the operation of applications to authorized domains is described herein. The method can include the steps of receiving reference domain restriction data associated with an application and receiving generated domain restriction data associated with the application. A domain restriction check can be performed by comparing the generated domain restriction data with the reference domain restriction data, In addition, a domain restriction approval signal can be generated if the domain restriction check is satisfied. The domain restriction check can ensure that the application will not operate in unauthorized domains.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: The present disclosure relates to novel methods for using treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The disclosure also relates to kits for treatment and/or prevention of ischemic lesions, which include an effective amount of treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: A method for generating a secure application is described herein. The method can include the steps of obtaining a target application and decomposing the target application into original files that contain predictable instructions. One or more predictable instructions in the original files may be identified. In addition, the target application may be modified to create the secure application by binding one or more intercepts to the target application. These intercepts can enable the modification of the predictable instructions in accordance with one or more policies such that the behavior of the secure application is different from the original behavior of the target application. Modification of the target application may be conducted without access to the source code of the target application.

Abstract: A method for sharing a virtual private network (VPN) connection among applications is described herein. In an environment in which multiple applications exchange data through the use of the virtual file system, a VPN for a first application can be established, and it can be determined that the first application is deactivated. Upon the determination that the first application is deactivated, a state of the VPN can be saved in a shared memory through the virtual file system. It may also be determined that a second application is activated. A VPN connection can be established for the second application by resuming the saved VPN state through the virtual file system.

Abstract: The present invention describes methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of interstitial lung disease or asthma, or a condition, such as pulmonary fibrosis, associated with interstitial lung disease or a condition associated with asthma. The invention also relates to kits for treatment and/or prevention of such condition that include an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —S—R14; and other substituents are as defined in the specification.

Abstract: The present invention describes novel methods for using 9-deoxy-2?,9-?-methano-3-oxa-4,5,6-trinor-3,7-(1?,3?-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: A contact element (1) for providing an electrical contact between a first electrical device (7) and a second electrical device, wherein the contact element (1) comprises a first contact portion (2) to be electrically connected to the first electrical device (7) and a second contact portion (4) to be connected to the second electrical device. The first contact portion (2) is arranged at a distance (D) to the second contact portion (4), whereby the contact element (1) comprises further an adjustment portion (3) connecting said first and second contact portion (2, 4), wherein with said adjustment portion (3) said distance (D) between the first contact portion (2) and the second contact portion (4) is adjustable.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.