Abstract: The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.

Abstract: The present invention provides compounds of formula I wherein R1, R2 or R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

Abstract: A magnetic field sensor package comprises a chip carrier, a magnetic field sensor which is arranged on the chip carrier and designed to detect a magnetic field, an integrated circuit which is arranged on the chip carrier and designed to logically process sensor signals provided by the magnetic field sensor, and at least one integrated passive component which is electrically coupled to at least one of the magnetic field sensor or the integrated circuit.

Abstract: The invention relates to a valve. A valve seat (2) encloses a fluid passage (20) for passage of a fluid from a fluid chamber (3). A holding element (4) exerts a holding force on a valve body (1), the holding force acting in a direction towards a valve seat (2). In the event that the fluid acts on an effective surface (10) of the valve body (1) with a force or a pressure above a limit value, the valve body (1) moves away from the valve seat (2). In the event that the fluid acts on an effective surface (40) of the holding element (4) with a force or a pressure above a limit value, the holding force acting on the valve body (1) decreases. In doing so, the fluid acts on the holding element (4) more strongly and/or earlier than on the valve body (1).

Abstract: Provided is a method (200) for generating a combined anatomical model of a heart. The method comprises receiving (220) a non-contrast agent-enhanced ultrasound image of a left ventricular region of the heart and receiving (240) a contrast agent-enhanced ultrasound image of the left ventricular region of the heart. Image registration (260) is performed on the respective non-contrast agent-enhanced and contrast agent-enhanced ultrasound images, such that the respective images are aligned. Combined segmentation (270) of the aligned non-contrast agent-enhanced and contrast agent-enhanced ultrasound images is then carried out to generate the combined anatomical model. The combined segmentation (270) uses features of both of the aligned non-contrast agent-enhanced and contrast agent-enhanced ultrasound images as target points. Further provided is a processor arrangement adapted to implement the method and an ultrasound system comprising the processor arrangement.

Abstract: Described herein are processes for purifying infectious virus particles and uses of protamine in such processes.

Abstract: A cargo reversed tricycle apparatus and method providing an open front, allowing the encompassing of cargo and a low center of weight when carrying, allowing more options in loading, transporting, and unloading and improved stability and maneuverability. A front-open frame provides cargo space between the front wheels, and allows for a variety of ways to load, transport, and unload the cargo. A dual-crossed-drag-link steering arrangement is provided, where a drag-link driver linked to the handlebar pushes and pulls shaped link rods, which transfer the forces through pivot links on turning bars on the two front-wheel units, which thereby turn in the intended direction.

Abstract: A valve suitable for an air spring includes a housing body with a central longitudinal axis and channel. The housing body has a first valve opening fluidically connectable to an air spring volume, a second valve opening fluidically connectable to an air supply, which is fluidically connectable to an air spring volume, and a second valve opening which is fluidically connectable to an air supply. Each valve opening is fluidically connected or selectively connectable to the channel. A pressure limiter is provided to limit the pressure flowing out of the second valve opening, the pressure limiter including a third sealing agent and a second sealing agent associated with the second valve opening and selectively closing an opening, wherein pressurization of at least the third sealing agent displaces the second sealing agent due to the forced coupling such that it closes the corresponding opening or reduces the effective opening cross-section.

Abstract: Slice alignment approaches are described for short axis cardiac magnetic resonance cine slice stacks, which do not require additional scans, such as long axis scans or full 3D scans, and which are able to deal with cardiac structures having complex shapes. Both approaches do not need contours to follow a quadratic curvature function, and are well suitable for the purpose of obtaining a segmentation of a cardiac structure using a deformable surface model. Namely, such a deformable surface model is unable, but also not desired, to fully adapt to the ‘zig-zag’-shaped pattern in the boundary of the cardiac structure due to the slice misalignment. Having removed or reduced the misalignment between image slices, such a deformable surface model may better adapt to the cardiac structure in the image data and 10 thereby provide a better segmentation of the cardiac structure.

Abstract: There is provided a method and apparatus for refining a model of an anatomical structure in an image. A model for the anatomical structure in the image is acquired. The model comprises a plurality of control points, each control point corresponding to a feature in the anatomical structure. The model is placed in the image with respect to the anatomical structure. Based on a user input received to adjust the model in the image, a position of at least one of the plurality of control points is adjusted to alter a shape of the model to the anatomical structure in the image, wherein adjustment of the position of one or more of the at least one control points is restricted based on information relating to the at least one control point.

Abstract: Described herein are improved purification methods for Zika virus vaccines and compositions. Also described are Zika vaccines and methods of producing and administering said Zika vaccines to subjects in need thereof.

Abstract: The invention provides for a method for switching between fields of view of an ultrasound probe. The method begins by obtaining an anatomical model representing a region of interest of a subject and establishing a first field of view relative to an ultrasonic probe, wherein the first field of view comprises an initial portion of the region of interest. Ultrasound data is then obtained from the first field of view by way of the ultrasonic probe and a first anatomical feature is identified within the first field of view based on the ultrasound data. A location in digital space of the first field of view relative to the anatomical model is determined based on the first anatomical feature. A second field of view is then established based on the anatomical model and the first field of view, wherein the first field of view functions as a reference field of view. The field of view is then switched from the first field of view to the second field of view.

Abstract: A pressure retaining valve including: a first valve body for an opening of an air spring, the first valve body having an access opening; a second valve body connected to the first valve body and having a chamber fluidly communicating with the access opening and having a side outlet opening; and a return member disposed outside the access opening in the chamber for providing a bias toward the access opening; a closure part disposed in the chamber and movable from a closed condition against the bias to an open condition; and an actuator part having a head portion, a shaft section, and a flow channel, the head portion disposed outside the access opening and having a larger diameter than the access opening, wherein the stem portion is movably disposed through the access opening into the chamber, and the actuator member can move the closure member out of the closed condition.

Abstract: An image analysis method and device is for detecting failure or error in an image segmentation procedure. The method comprises comparing (14) segmentation outcomes for two or more images, representative of a particular anatomical region at different respective time points, and identifying a degree of consistency or deviation between them. Based on this derived consistency or deviation measure, a measure of accuracy of the segmentation procedure is determined (16).

Abstract: The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.

Abstract: An ultrasound control unit (12) is for configuring visualization of ultrasound data using in use a display unit. The control unit is adapted to acquire ultrasound image data and to automatically control visualization of the most relevant parts and views the data, based on current levels of a number of different monitored physiological parameters. In particular, responsively to one of the physiological parameters entering or leaving a pre-defined range of values (e.g. representative of an alert or normal condition respective for the patient), the control unit determines a most appropriate anatomical region within the image data for representing the changed physiological parameter, and a most useful visualization mode (e.g. view) for presenting or showing that anatomical region within the image data. One or more display frames are generated which show the anatomical region visualized in accordance with the selected visualization mode.

Abstract: Disclosed are photoactivable fluorescent dye compounds of formula I: wherein: n=0, 1, 2, 3; X is selected from O, CRR?, SiRR? and GeRR?, where R and R? represent independently alkyl, cycloalkyl, alkenyl, alkynyl or aryl; Y is H, SO3H or SO3M, with M being a positively charged counterion, in particular selected from NH4+ and cations of organic ammonium compounds; R1 is H, CO2H, C(O)NH-linker-CO2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; R2 may represent H, unsubstituted or substituted alkyl (including cycloalkyl); R3 and R4 may represent independently H or F; R5 is H, Me, CO2H, C(O)NH-linker-CO2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; wherein the ligand moiety at each occurrence represents a reactive group or tag, capable to form a covalent or non-covalent bond or molecular complex with a target chemical entity or substance. Methods of using the compounds in imaging of fixed and living cells are also disclosed.

Abstract: Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

Abstract: Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.